ISD researchers found that the brain’s modular network organization influences how amyloid-driven tau pathology spreads. Published in Alzheimers&Dementia: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Institute for Stroke and Dementia Research (ISD)
@isd-research.bsky.social
Welcome to the Institute for Stroke and Dementia Research (ISD) in Munich – Director: Prof. Martin Dichgans https://www.isd-research.de/
ISD researchers investigated how plasma biomarkers (phosphorylated tau 217 [ptau217], glial fibrillary acidic protein [GFAP], neurofilament light chain [NfL]) relate to imaging markers of SVD and AD, and cognition in memory clinic patients. -> doi.org/10.1002/alz....
www.nature.com/articles/s41...
A deep-learning framework reveals whole-body perturbations at cell level - Nature
An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.
nature.com
The SFB 1744 / CRC 1744 website is now published www.sfb1744.de 🎊 It not only represents work, events, publications of the CCN in NVD network but furthermore offers a platform for the Graduate Program IRTG-BrainVasc including open PhD positions! www.sfb1744.de/sfb1744 www.sfb1744.de/open-positio...
Advanced Clinician Scientist Program for Comprehensive Neuroscience (PROMISE) www.med.lmu.de/de/wissensch...
CRC1744 Launch – Kick-off Event With the official launch of CRC1744 we welcomed principal investigators and early career researchers as well as distinguished guest speakers to a one-day kick-off meeting. www.isd-research.de/news/crc1744...
A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology | Science Translational Medicine www.science.org/eprint/5H5YD...
A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology
A human iPSC–derived tauopathy model endogenously recapitulates late-stage pathology and enables translational applications.
science.org
ISD Investigators have secured major funds from Germany’s Federal Ministry of Research, Technology and Space, to strengthen clinician-led, translational neuroscience research. PROMISE will support 12 competitively selected Advanced Clinician Scientists >> www.isd-research.de/scrivito/adv...
Image of the Week: Congrats to the team of González-Gallego J et al., Nat Neurosci. 2026 for this lovely award in Nature Briefing 🏆 🖼️ @judit-gonzalez.bsky.social @paquetlab.bsky.social (->Fig 2b www.nature.com/articles/s41...)
PaquetLab@paquetlab.bsky.social · 8mo agoNew paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10
Frühe und verlässliche Diagnostik ist ein Schlüssel in der Alzheimer-Forschung. Dr. Anna Dewenter forscht am @isd-research.bsky.social der @lmu.de genau daran. In ihrem AFI-Projekt untersucht sie mithilfe moderner MRT-Bildgebung feine Veränderungen der weißen Hirnsubstanz.
Vollautomatisiertes Verfahren zur Diagnostik einer Alzheimer-assoziierten Gefäßerkrankung
YouTube video by Alzheimer Forschung Initiative
youtube.com
Brain-derived tau for monitoring brain injury in acute ischemic stroke - Great work by Steffen Tiedt, his team of ISD researchers and international partners now published in Science Translational Medicine: www.science.org/doi/10.1126/... 🎊🙌 #BD-tau #ischemic
Brain-derived tau for monitoring brain injury in acute ischemic stroke
Brain-derived tau in plasma reflects the extent of brain injury in acute ischemic stroke, predicts functional outcomes, and detects treatment effects.
science.org
New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10
Congratulations! 🏆 The European Research Council has awarded the prestigious ERC Consolidator Grant to support TRAINED, a project led by Arthur Liesz (ISD) that investigates how maladaptive trained immunity drives systemic inflammation and multimorbidity after stroke and myocardial infarction.
German Research Foundation (DFG) has approved funding of a new CRC on “Compartmentalized Cellular Networks in Neurovascular Diseases”. Thanks to everyone involved!🙏 www.lmu.de/en/newsroom/...
Synaptic density and tau pathology in Alzheimer’s disease: a dual role in susceptibility and degeneration url: academic.oup.com/brain/articl...
Synaptic density and tau pathology in Alzheimer’s disease: a dual role in susceptibility and degeneration
Luan et al. used dual PET imaging to examine the relationship between synaptic density and tau pathology in Alzheimer’s disease. They show that synapse-ric
academic.oup.com
Happy to find Martin Dichgans on the list of Highly Cited Researchers™ once more 🎉 clarivate.com/highly-cited...
Key risk factors for post-stroke dementia uncovered: results from DEMDAS study identify metabolic syndrome + reduced HDL cholesterol as novel, modifiable risk factors for post-stroke dementia... www.thelancet.com/journals/lan...
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease url: academic.oup.com/brain/articl... #tao @nfranzme.bsky.social
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease
In Alzheimer’s disease, tau pathology not only contributes to cortical atrophy but also leads to the degeneration of white matter tracts that connect diffe
academic.oup.com
Marios Georgakis and team showed IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk www.nature.com/articles/s44...
Mikael Simons receives $500,000 for a project to investigate disease mechanisms involving tau proteins. The funding is part of the international program „Tauopathy Challenge Workshop 2025“, supporting research projects aimed at understanding and treating tau-associated diseases such as AD. 🎉
Annual ISD Research Retreat 🎆 Great talks, project presentations, poster session, games, guest talks and an amazing LLM workshop by Rainer Malik 🙏
Arthur Liesz received the prestigious ESO Scientific Excellence Award for his contributions to the understanding of stroke and neurovascular disease. The award was delivered in the Presidential Session at the European Stroke Organisation Conference (ESOC 2025) in Helsinki. @arthurliesz.bsky.social 👏
The Munich Cluster for Systems Neurology (SyNergy) has been awarded a third funding period (2026-2032) by the DFG. 🎆 👏 @synergy-munich.bsky.social
Die Europäische Kommission hat den Wirkstoff Lecanemab (Handelsname: Leqembi) zur Behandlung der Alzheimer-Krankheit im frühen Stadium zuzulassen. Damit wird es erstmals in Deutschland eine Alzheimer-Behandlung geben, die ursächlich an einer der möglichen Krankheitsursachen angreift.
Zulassung Leqembi
Europäische Kommission lässt Wirkstoff Lecanemab (Handelsname: Leqembi) zur Behandlung der Alzheimer-Krankheit im frühen Stadium zu.
alzheimer-forschung.de
Interested in cellular mechanisms of cognitive decline after stroke? Check out this work in Nature communications: Anna-Sophia Wahl lab track the fate of individual neurons involved in spatial memory before + after multiple, distributed microstrokes using chronic 2photon imaging in-vivo. 👍
Brain-wide microstrokes affect the stability of memory circuits in the hippocampus
Nature Communications - To reveal cellular mechanisms of cognitive decline after stroke the authors established an experimental paradigm in mice monitoring individual nerve cells involved in...
rdcu.be
For his research project “Reprogrammed microglial cells as a therapeutic approach against Alzheimer's Disease” Dominik Paquet receives funding from the Alzheimer Forschung Initiative 🙌 @afi-ev.bsky.social www.alzheimer-forschung.de/forschung/fo...
Alpha-synuclein co-pathology promotes tau accumulation in Alzheimer’s disease - findings by ISD investigators published in Molecular Neurodegeneration 👏 rdcu.be/ed0Su @nfranzme.bsky.social @springernature.com
An atypical chemokine that links atherosclerosis and metabolic disease - A new study led by ISD staff identifies D-dopachrome tautomerase (D-DT/MIF-2) as an atypical chemokine that promotes both atherosclerosis and hepatic lipid accumulation. (...) read: 👉 www.isd-research.de/scrivito/isd... 👏
Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply
