Long time in the making and finally out. Great work by Lucas and @haosha.bsky.social who wrote the code, Maxime and Nestor for the beautiful samples and @zacsimile.bsky.social for helping to wrap this up. Try it out!

Hao Sha@haosha.bsky.social · last mo.

[0/1] Excited to share our new preprint DECODE-Plex! After many people efforts, we developed a deep-learning framework for multi-channel SMLM, enabling simultaneous localization and color assignment of densely packed emitters across multiple channels. biorxiv.org/content/10.6...

One frame. Many voices. 📢 From Vienna to Yale and Göttingen – and now back in Vienna – Sarah Schweighofer (Ries lab) has built her path in molecular biology and super-resolution microscopy, driven by a fascination for making the invisible visible🔬

See also our preprint about the microscope itself, which went up earlier this afternoon! www.biorxiv.org/content/10.6...

Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo www.biorxiv.org/content/10.6...

Congrats to @zacsimile.bsky.social (Ries lab) on receiving an @fwf-at.bsky.social ESPRIT Fellowship to pursue his microscopy research at the Perutz! 🔬Zach aims to develop faster super-resolution imaging approaches to visualize clathrin dynamics in living cells ➡️ tinyurl.com/yc5veky6

0/10 🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology Continuum architecture dynamics of vesicle tethering in exocytosis www.cell.com/cell/fulltex...

Continuum architecture dynamics of vesicle tethering in exocytosis

Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

cell.com

Now out in @natcomms.nature.com: www.nature.com/articles/s41...! The latest GitHub commits/Colab notebooks enable simulation with 3D sequences.

Jonas Ries@jonasries.bsky.social · last yr.

Check out our new MINFLUX Simulator: www.biorxiv.org/content/10.1... with @zacsimile.bsky.social. Realistic simulation of optics, mechanics, fluorophore dynamics and estimators. @abberior.rocks users can directly simulate sequence files.

✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

It is out! 🦚 I recorded hundreds of #ExM 🔬images of cytokinetic bridges and averaged them into 6 stages. How? With help from our fantastic collaborators @zacsimile.bsky.social and @jonasries.bsky.social in Vienna 😇. Check out the full atlas here: doi.org/10.5281/zenodo.17232370

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

@embl.org Heidelberg is looking for a new Head of Scientific Instrumentation! This is an exciting opportunity at the interface between scientific research and technology development, overseeing our mechanical and electronic workshops! embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Head of Scientific Instrumentation Workshops

EMBL is a world leader in scientific research and at the forefront in the development of cutting-edge technologies. It operates across six sites in Heidelberg (headquarters), Barcelona, Cambridge, Gre...

embl.wd103.myworkdayjobs.com

Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader – AI in Biology

Are you ready to lead groundbreaking research in AI for Biology? Join us at EMBL! We are seeking a visionary scientist to establish their own independent research group bridging innovations in machine...

embl.wd103.myworkdayjobs.com

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

🚨 2 × PhD positions @EPFL! 🚨 Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch #PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Head of the Cell Biology and Biophysics Unit

The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

embl.wd103.myworkdayjobs.com

Opening for a professorship in multimodal imaging in the context of our cluster of excellence #3DMM2O. Here is the full advertisement with all details: tinyurl.com/2ksy2b2s

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c

🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8

Check out our new MINFLUX Simulator: www.biorxiv.org/content/10.1... with @zacsimile.bsky.social. Realistic simulation of optics, mechanics, fluorophore dynamics and estimators. @abberior.rocks users can directly simulate sequence files.

MINFLUX works well in theory, but system and sample imperfections can lead to suboptimal resolution. To address this, @jonasries.bsky.social and I developed SimuFLUX: www.biorxiv.org/content/10.1..., a realistic simulator to optimize MINFLUX experiments before samples go on the microscope.

Evaluating MINFLUX experimental performance in silico

MINFLUX is a super-resolution microscopy technique with remarkable resolution for imaging and tracking. Its optical resolution is well understood under idealized conditions, but because of system comp...

biorxiv.org

After a few (expected) Deutsche Bahn glitches I am on my way to Vienna! Excited to visit @jonasries.bsky.social at @viennabiocenter.bsky.social tomorrow and @nartimsoole.bsky.social at ISTA on Thu! Come by and say hi and hear about what the lab has been up to! Also my first time ever in Vienna!

👏 Congrats to Sarah Schweighofer, postdoc with @jonasries.bsky.social, on being awarded a Marie Curie fellowship! She will explore how mitochondrial fragmentation is regulated during programmed cell death using super-resolution microscopy 🔬✨ Read more ➡️ tinyurl.com/2p8yacme @univie.ac.at

By putting a donut between our faces and each article we read, we were able to extract more information than ever before about MINFLUX. You can read the new review article from @maxperutzlabs.bsky.social by Lukas Scheiderer, myself, and @jonasries.bsky.social at www.nature.com/articles/s41...

MINFLUX achieves molecular resolution with minimal photons - Nature Photonics

The authors review MINFLUX super-resolution microscopy, outlining its advantages and limitations, recent progress, and an outlook for future developments.

nature.com

The Ries group at @maxperutzlabs.bsky.social wishes all of you Happy Holidays all the best for 2025! (Actin and clathrin in super-resolution, credits: Aline Tschanz)