EMBL and University of Washington researchers have developed NovoTags – AI-designed protein tags – that in future could help researchers combine fluorescence microscopy and cryo-ET, helping identify individual proteins inside cells. @steffenklein.bsky.social More info 👉 www.embl.org/news/science...

Super cool cryo-ET work from my colleague Xiaohan resolving a ton of ribosome assembly intermediates in the nuclei of human cells!

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 2mo ago

In-cell structures visualize human pre-ribosome assembly in the nucleolus https://www.biorxiv.org/content/10.64898/2026.06.01.729245v1

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo www.biorxiv.org/content/10.6...

We @embl.org wrote a short preprint about optimizing for maximum completeness in #cryoet analysis. We looked at template matching, VPP imaging, and tilt-series refinement parameters, and why averaging ribosomes helps even if you aren’t interested in their biology 🏭 www.biorxiv.org/content/10.6...

Really excellent work by the bluesky-less Marie and Sara +coauthors in our lab @embl.org! Check it out for cool combinations of light microscopy and #cryoET, and if you're interested in how yeasts reorganize structurally in response to stressors. #teamtomo

bioRxiv Molecular Biology@biorxiv-molbio.bsky.social · 8mo ago

Structural reorganization underlying stress-induced cytoplasmicsolidification in yeast https://www.biorxiv.org/content/10.64898/2025.12.22.696049v1

Congratulations, Julia Mahamid! Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology! #LeibnizPreis

Deutsche Forschungsgemeinschaft@dfg.de · 8mo ago

Und hier sind sie – die 10 Preisträger*innen des Gottfried Wilhelm #LeibnizPreis' 2026 – ausgezeichnet für ihre exzellenten Forschungsarbeiten und Errungenschaften in der Wissenschaft! 🏆👏 Die Verleihung der Preise feiern wir am 18. März in Berlin. Einzelheiten & Kurzprofile: sohub.io/1uv1

Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️ www.biorxiv.org/content/10.1... #teamtomo

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...! Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more! Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

The small GTPase Ran defines nuclear pore complex asymmetry

Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…

sciencedirect.com

New paper from my colleague Soheil in the Mahamid and @jonasries.bsky.social groups looking at factors influencing laser devitrification on frozen #cryoem samples. With a far-red fluorophore, all-gold support grids will be especially good for correlative cryo-SMLM and EM! doi.org/10.1016/j.js...

Are you into cryo-ET, in-cell discovery, protein translocation and folding or just cool integration of structural biology, proteomics and bioinformatics? Then see our new work: www.biorxiv.org/content/10.1... Thank you to all coauthors for your amazing work!