Denise J. Cai, Ph.D.

@denisejcai.bsky.social

Prof. of Neuroscience @SinaiBrain · Investigating memory stability & flexibility · Advocate for open science · Mom of two littles · Amateur chef · she/her · denisecailab.com

Representational drift - the change in cells' responses to the same stimulus over time - may be a feature rather than a bug. Thank you to @dianakwon.bsky.social for giving me a chance to talk about this fascinating topic. 🤯 The brain never ceases to amaze!

Diana Kwon@dianakwon.bsky.social · 3mo ago

My latest feature for @nature.com is about "representational drift," a concept that's turned some long-standing ideas of how the brain works on its head. “When people talk about this phenomenon, it’s exciting because it’s just so full of possibilities." - Andrew Fink

Reminder: Your impact is bigger than just papers ✨ At this year's Slaydies retreat, we gave each other personalized awards, holistically honoring the way we show up for each other in the neuroscience field and beyond. I'm so grateful for this community 💜

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🤓 Really excited to host this panel at COSYNE! Our incredible speakers Bing, Kenji, Kim & Saskia are sure to share insightful advice on making an impact in their career and community at every stage of their careers 🧑‍🔬 🧠

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As a past Next Generation Leader, I can definitively say the program helped shape how I approach my science. Collaboration is key to making an impact, and so is backing innovation with values-driven research. I highly recommend applying for this program 🧠

allen institute@alleninstitute.org · 5mo ago

Applications for our Next Generation Leaders program are open! For 3 years, accepted early career scientists will join a supportive network and contribute to our research initiatives. Apply by Mar. 31: https://bit.ly/3OjzdRa 📸 Photo by NGL Alum @bjmarlin.bsky.social

How does neuronal gene expression evolve over time in response to experience? CytoTape will help us find out - a major milestone for neuroscience, providing new ways to study memory & aging 🧠 Congrats to the whole team! Looking forward to our continued collaboration on this work 🎉

Changyang Linghu@changyanglinghu.bsky.social · 6mo ago

Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...

CytoTape in a neuron

What happens when a neuroscientist realizes trauma rewired their own brain? ❤️‍🩹 I’ll be sharing that very personal story - the intersection of my research, insights it's brought me & the healing journey I've embarked on - LIVE & LIVESTREAMING on 1/26! Tickets 👇 www.storycollider.org/tickets/2026...

The Friedman Brain Institute@sinaibrain.bsky.social · 7mo ago

On Jan 26, Do Not Miss UNSPOKEN, an @storycollider.bsky.social event @caveatnyc.bsky.social! JOIN Diana Li & @paulacroxson.bsky.social when they host @denisejcai.bsky.social & 4 other story tellers for an unforgettable evening of deeply personal stories.🎟️🎟️ 👉 www.storycollider.org/tickets/2026...

The Cai & Shuman Labs threw an EPIC White Elephant party! So much holiday cheer packed into one room. We did not have a partridge in a pear tree, but we did have: 👥 25 members laughing 🥔 6 chip-bags-a-gifting 🪴 5 plants-afloating 🦫...and a capybara in a knit hat!

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Wow, such an insightful and substantive open floor discussion at last night's Memory Hub meeting! 🤓 Do we need ANY of the same synapses that were active during learning to be reactivated to recall a memory? Lines have been drawn and sides taken!

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I'll be at Zoé and Zach's posters today, giving out VIP access bracelets for the Cai-Tye Collective event tonight! If you're at #SfN25, come check out Zoé and Zach's work and snag a bracelet before we run out!

Denise J. Cai, Ph.D.@denisejcai.bsky.social · 9mo ago

Are you at #SfN25 and want VIP access to the Cai-Tye Collective event on Nov 17? Come by my lab members' posters for a bracelet! Hailey Rosenblum: Nov 15, 1-5pm PSTR040.05/BB6 Zoé Christenson Wick: Nov 17, 8am-12pm PSTR192.01/RR13 Zach Pennington: Nov 17, 1-5pm PSTR234.05/CC7