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Fatima Pereira@fatimacpereira.bsky.social · last yr.

If you are into #posttranscriptional modifications, gut #inflammation, #immunology or #gutmicrobiome check out our latest work @jem.org 👇 Big team effort @miershawig.bsky.social @connyves.bsky.social Big thanks to @fwf-at.bsky.social for funding!

Check out our exciting paper by @asmafarhat.bsky.social in @scienceimmuno.bsky.social. In a nutshell: in lung fibrosis, the age of the bone marrow matters more than the age of lung tissue. check out the threat by Asma below 👇 Thanks to co-lead @miershawig.bsky.social and all collaborators :)

Asma Farhat@asmafarhat.bsky.social · 2y ago

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis. 🔗 www.science.org/doi/10.1126/...

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis. 🔗 www.science.org/doi/10.1126/...

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence

Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

science.org