Congrats to superstar @asmafarhat.bsky.social for being selected as a Simons Postdoctoral fellow to study how inflammation impacts sensory development and function in the Naik lab and Allen Discovery Center. @simonsfoundation.org @sinaiimmuno.bsky.social www.simonsfoundation.org/people/asma-...

Asma Farhat

Asma Farhat on Simons Foundation

simonsfoundation.org

Congrats to @asmafarhat.bsky.social from the group of former #CeMM PI Sylvia Knapp (@knapplab.bsky.social), on successfully defending her PhD thesis entitled "From Bone to Breath: How hematopoietic aging shapes macrophage fate, function & lung fibrosis." Well done!! 🎓 👏 🎉 #phdlife #phdhat

#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis www.science.org/doi/10.1126/...

Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes

Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.

science.org

Congrats to Sylvia Knapp and team on their new Science Immunology paper! They show how aged bone marrow drives lung fibrosis by sustaining profibrotic macrophages. Reduced T-reg IL-10 worsens healing, revealing key immune-aging links. www.science.org/doi/10.1126/... #Immunology #LungFibrosis

Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Huge congratulations to @mariemradhouani.bsky.social who spearheaded this brilliant and seminal study out now in Science Immunology @science.org !! science.org/doi/10.1126/sciimmunol.adp6231 Lucky to have been a part of this team from @starkllab.bsky.social Read more on Mariem's thread below!

Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation

Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.

science.org

Mariem Radhouani@mariemradhouani.bsky.social · last yr.

I'm excited to share my first-author PhD paper, now out in Science Immunology! @science.org We show that S.aureus skin infection leaves a lasting imprint on bone marrow eosinophils, fueling allergic responses in the lungs. 📄 Read the full study: www.science.org/doi/10.1126/... Let’s dive in 🧵 1/9

Using a fibrosis model in young vs aged mice, Farhat and Knapp show that an aged bone marrow autonomously produced more profibrotic Mo-AMs, had a reduced availability of Tregs-derived IL-10 causing exacerbated lung fibrosis. [4/n] www.science.org/doi/10.1126/...

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence

Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

science.org

Here, we go. Starting 2025 best lung papers. Will add as I go along and also updated on the blog. payalyokota.com/lung-macroph...

Lung Macrophages — payal yokota

payalyokota.com

Very cool (and surreal!) seeing my paper featured on the Science homepage www.science.org !! #ScienceImmunology science.org/doi/10.1126/sciimmunol.adk5041

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis. 🔗 www.science.org/doi/10.1126/...

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence

Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

science.org

#macrophage #barcoding 🤯 Time to get rid of the "fetal liver monocyte" origin for resident macrophages?!? Congrats to the Rodewald lab for this work! www.biorxiv.org/content/10.1...

Holistic genetic barcoding reveals a lineage tree of tissue macrophage development

Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with comp...

biorxiv.org

REVIEW: Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level www.nature.com/articles/s41... @davidfinlaytcd.bsky.social