Congratulations to the Walczak lab for this amazing piece of work just pulisbed on @natcellbio.nature.com A must read!!! This work adds a new letter of the ubiquitin code to immune signaling regulations! www.nature.com/articles/s41...

Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 - Nature Cell Biology

Betrancourt, Cinko et al. identify ANKIB1-mediated K11 ubiquitination and OPTN recruitment as a shared mechanism for driving immune signalling by cGAS, TLR3 and TLR4, with functional relevance in inte...

nature.com

Fantastic work in collaboration with @vonkarstedtlab.bsky.social available on Cell Death & Discovery. Ibrutinib sensitises to ferroptosis induction to kill DLBCL. #cancer #lymphoma #dlbcl doi.org/10.1038/s414...

Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL) - Cell Death Discovery

Cell Death Discovery - Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)

doi.org

Silvia von Karstedt @vonkarstedtlab.bsky.social · 10mo ago

Happy to share an incredibly efficient collaboration with @gianmaria-liccardi.bsky.social : Ibrutinib cooperates with #ferroptosis induction to kill #dlbcl www.nature.com/articles/s41...

Thank you @fattoquotidiano.bsky.social for covering our @nature.com article. www.ilfattoquotidiano.it/2025/08/21/m... Reserach article: doi.org/10.1038/s415...

The STING of death continues! Thanks to @natrevrheum.nature.com (doi.org/10.1038/s415... & rdcu.be/eJjhl ) for highlighting our recent @nature.com paper (doi.org/10.1038/s415...) cell death inhibition as a therapy for autoinflammatory diseases (SAVI) #immunity #celldeath #rheumatology #vasculitis

Just found this post from Nature on the AAP of our paper. Soon the official print version…

Nature [Unofficial]@nature.com.web.brid.gy · last yr.

I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.

In my lab we are interested in understanding how aberrant activation of cell death & inflammation drive loss of tissue homeostasis and how genetic instability contributes to the loss of this balance. If you are interested in discussing this topic, joining our lab or collaborate please let me know.

Just back from the TNF CONFERENCE in China, Full of ideas and inspiration. Thank you to the organisers for such an amazing conference and line up of fantastic speakers #tnf #celldeath #innateimmunity