New paper in Imaging Neuroscience by Joline M. Fan, Keith R. Murphy, et al: Toward a transcriptomic framework for ultrasound neuromodulation: A perspective on gene expression and regional brain sensitivity doi.org/10.1162/IMAG...
Michael Fox
@foxmdphd.bsky.social
Raymond D. Adams Endowed Chair and Professor of Neurology at Harvard Medical School / Mass General Brigham; Director of the Center for Brain Circuit Therapeutics @braincircuits.bsky.social
New publication using Lead-DBS: In this article by Barlatey et al., the authors tested the robustness of DBS lead reconstruction using two distinct postoperative CT scans per patient and found mean lead tip translation of 0.79 mm, ind... Check out the paper here 👇👇 https://doi.org/10.1159/000552349
Is brain circuit targeted TMS better than standard clinical TMS for treating depression? New study led by Joe Taylor @braincircuits.bsky.social out today in @jamapsychiatry.com says yes! Connectivity- vs Scalp-Based Targeting of Accelerated TMS for Depression jamanetwork.com/journals/jam...
Connectivity- vs Scalp-Based Targeting of Accelerated TMS for Depression
This randomized clinical trial estimates the effect size of connectivity- vs scalp-based targeting of accelerated transcranial magnetic stimulation for treatment-resistant depression.
jamanetwork.com
New UCL research has identified a brain network linked to diffuse midline glioma (DMG), one of the deadliest childhood brain cancers. Published in Nature, the study suggests a tumour's location within this network may help predict outcomes and guide future treatments. https://bit.ly/3S8109e
Can lesion network mapping predict survival in children with brain tumors? Collaboration with UCL and @braincircuits.bsky.social in @nature.com suggests the answer is yes. Cutting the tumor off from this network may provide survival benefit. www.nature.com/articles/s41...
A prognostic human brain network for diffuse midline glioma - Nature
Tumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherw...
nature.com
How do you build a brain circuit treatment for patients with the most severe form of epilepsy? Start by finding the brain circuit target. Great talk by @rolstonjohn.bsky.social @braincircuits.bsky.social
Where, exactly, does learning happen in the brain? Out today in @nature.com, we identify a synaptic locus of birdsong learning and show that the circuit can be tuned to make birds learn faster - but at a cost. Read on👇 #neuroskyence 🧪 #prattle 💬 #bioacoustics Shareable link: rdcu.be/fiyrS
A synaptic locus of song learning - Nature
Combining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the specific cortico-basal ganglia synapse...
nature.com
The rarely told story of DBS before DBS from an industry perspective. Thank you very much, Keith Mullett, for taking part in this interview! Tune in below:
Stimulating Brains@stimulatingbrains.org · 3mo agoWhat was deep brain stimulation before the Benabid era? Listen to this new episode with a very unique view behind the scenes at Medtronic developing DBS for pain, just in time for the Grenoble team to come in: stimulatingbrains.org/78-keith-mul...
Moreover, did you know that Stimulating Brains Episodes are now searchable – and citeable? Check the website for a transcript player with search functionality – great to check back to "something you've heard" on the show in some of the episodes. All transcripts also available on figshare etc.
Stimulating Brains@stimulatingbrains.org · 3mo agoWhat was deep brain stimulation before the Benabid era? Listen to this new episode with a very unique view behind the scenes at Medtronic developing DBS for pain, just in time for the Grenoble team to come in: stimulatingbrains.org/78-keith-mul...
🧠 @foxmdphd.bsky.social and his BD² Discovery Research team at @mgbresearch.bsky.social are mapping brain circuits tied to specific bipolar symptoms—unlocking targeted neuromodulation treatments rather than one-size-fits-all approaches.
Thank you @avaskham.bsky.social @thetransmitter.bsky.social for covering the ongoing discussion re lesion network mapping. It is commendable when a news publication covers both sides of an issue, and a great example of unbiased and responsible reporting.
The Transmitter @thetransmitter.bsky.social · 4mo agoA wave of new papers discuss the merits and limitations of lesion network mapping. #neuroskyence By @avaskham.bsky.social www.thetransmitter.org/brain-imagin...
A wave of new papers discuss the merits and limitations of lesion network mapping. #neuroskyence By @avaskham.bsky.social www.thetransmitter.org/brain-imagin...
‘Overdue’ debate unfurls over neuroimaging method
After a January paper questioned the validity of an approach called lesion network mapping, its users are pressure testing their results.
thetransmitter.org
When clinicians and researchers work together toward the goal of improving lives for those with #bipolardisorder, collaboration shifts how research progresses. Hear from Tracy Young-Pearse, PhD, on BD²'s integrated approach in the latest #InvestigatorInsights. 🧠
Congratulations @shansiddiqi.bsky.social and Joe Taylor @braincircuits.bsky.social on their paper In Mol Psych demonstrating the translational power of LNM and brain circuit therapeutics. It has already changed clinical TMS practice @massgeneralbrigham.bsky.social @harvardmed.bsky.social.
Shan Siddiqi@shansiddiqi.bsky.social · 4mo agoNew paper in Molecular Psychiatry: In patients with anxiety + depression, targeting a novel “anxiosomatic” circuit (dmPFC) outperforms standard dlPFC for anxiety—and is equally effective for depression. Free link: rdcu.be/faL22 Full link: lnkd.in/e4WZTncu But the bigger story is the pipeline 1/n
New paper in Molecular Psychiatry: In patients with anxiety + depression, targeting a novel “anxiosomatic” circuit (dmPFC) outperforms standard dlPFC for anxiety—and is equally effective for depression. Free link: rdcu.be/faL22 Full link: lnkd.in/e4WZTncu But the bigger story is the pipeline 1/n
Should doctors be certified to deliver brain stimulation? @shansiddiqi.bsky.social @braincircuits.bsky.social says yes - kicking off the brain stimulation subspecialty summit (BraSS).
Many good points, one more: We empirically demonstrate that spatial bias does not contribute to real-world LNM findings when using appropriate specificity-testing: doi.org/10.64898/202...
doi.org
🧠 Resting-state fMRI is often treated as the gold standard for studying the brain’s intrinsic organization. But is it actually the best way to estimate functional architecture? We tested this directly. 🧵1/8
What’s the difference between a neurological vs psychiatric disorder? @braincircuits.bsky.social , it’s only the circuit impacted. Honored to become one of the first full Professors of both Psychiatry and Neurology @harvardmed.bsky.social Excited to help bridge this divide.
We don't think it invalidates the approach. We looked into this in our data and replicated the key result showing convergence to non-specific connectome structure. However, our results also suggest there is a practical fix that is already implemented in some LNM studies. bsky.app/profile/pete...
Marvin Petersen@petersenm.bsky.social · 5mo agoNew preprint: Revisiting the methodological foundation of lesion network mapping. doi.org/10.64898/202... A thread.
This is a robust response. I particularly liked this figure - clarifying why the original critique showed what it did, and what was missing @foxmdphd.bsky.social
Phil Corlett@philcorlett.bsky.social · 5mo agoThe lesion-network mappers reply 🍿
A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...
Michael Fox@foxmdphd.bsky.social · 5mo agoA recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...
A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...
biorxiv.org
New @netstim.org publication alert: @bahnebahners.bsky.social in BRAIN out now: academic.oup.com/brain/advanc... A 🧵:
The deep brain stimulation response network in Parkinson’s disease operates in the high beta band
Bahners et al. identify a brain network linked to optimal therapeutic outcomes in patients with Parkinson’s disease receiving deep brain stimulation. This
academic.oup.com
Can a brain injury make someone lose their imagination? We describe rare cases of acquired aphantasia, people who lost the ability to visually imagine after a stroke or other brain injury. Now published in Cortex 🧠 @braincircuits.bsky.social www.sciencedirect.com/science/arti...
Lesions Causing Aphantasia are Connected to the Fusiform Imagery Node
The absence of visual mental imagery, called aphantasia, occurs congenitally in up to 3% of the general population, but the brain regions responsible …
sciencedirect.com
One week away from launching our 2nd annual @harvardmed.bsky.social course Brain Medicine: Integrating the Clinical Neurosciences. On demand viewing for 30 days. Nearly 150 people registered. Join us! @jrbneuropsiq.bsky.social @foxmdphd.bsky.social learn.hms.harvard.edu/programs/bra...
Brain Medicine: Integrating the Clinical Neurosciences | Harvard Medical School Professional, Corporate, and Continuing Education
Explore cutting-edge advances in brain medicine with this interdisciplinary course designed to equip clinicians with integrated tools for assessing and managing complex brain disorders, featuring expe...
learn.hms.harvard.edu
The Shingles vaccine and reduction of dementia: a new natural experiment from Canada replicated 3 others and adds to this week's link to slowing of biological aging. erictopol.substack.com/p/spotlight-...
Spotlight on the Shingles Vaccine—Again!
Two new studies add to a remarkable body of evidence for benefit
erictopol.substack.com
Thanks to The Transmitter for reaching out to me for comments on this methodological challenge to lesion network mapping. Scientific debate is critical to methodological advancement - so let the debate begin! www.thetransmitter.org/brain-imagin...
Methodological flaw may upend network mapping tool
The lesion network mapping method, used to identify disease-specific brain networks for clinical stimulation, produces a nearly identical network map for any given condition, according to a new study.
thetransmitter.org
Are connectome-based network mapping methods and the >200 papers that have used it invalid? New paper out in @NatureNeuro says YES. nature.com/articles/s41... I have concerns about this new paper's methods and conclusions, but am biased. What do others think?
Investigating the methodological foundation of lesion network mapping - Nature Neuroscience
The lesion network mapping method links diverse brain lesions to similar functional brain networks, reflecting general brain organization rather than disorder-specific circuits.
nature.com