🫁 Had my lung capacity measured recently. Nurse asks with concern: "Have you started smoking?" Me: "No, but I recently started smoking crack." Dead silence. Pen hovering mid-air. Pure confusion. She did not put that in my chart. 💀
Thorsten Wagner
@thorstenwagner.bsky.social
Project group leader @ MPI Dortmund
is here someone who knows speech synthesis with XTTS v2 really well?
1/2 I'm part of the ANQUR clinical trial by QurAlis – testing QRL-201, a drug designed to restore a protein called STATHMIN-2 that most ALS patients lose. Interim data published last week show promising results. www.quralis.com/news/quralis...
QurAlis Demonstrates Effects on Disease Progression and Target Engagement in ANQUR Clinical Trial of QRL-201, a First-in-Class Precision Medicine in Development for Sporadic ALS - QurAlis
First clinical development program in sporadic ALS patients to show potential to restore STATHMIN-2 expression, a statistically significant effect on a
quralis.com
1/5 ALS takes a lot. But it doesn't take curiosity. A new thread: how I stay motivated – through projects that are meaningful, or simply fun 🧵
Great thread, Thorsten. You are our hero! You have done so much for our group - always with humor, always with fun, always eager to learn and curious: “the ones who spread love, get love back.”
I don't think we've met, but we've used crYOLO a lot in my group. I wanted to let you know that your thread is a real inspiration in terms of the human mind's resilience. We all eventually face disease and weakness, but very few cope with it the way you do. My thoughts are with you.
1/6 Living with ALS also means this: learning to count your privileges. A thread.
Thorsten Wagner@thorstenwagner.bsky.social · 6mo agoIn September 2024, I was diagnosed with ALS. Today, I can no longer speak, I am confined to a wheelchair, and I can no longer move my arms. It's really shitty. I will write here soon about how I am coping with this and how I am trying to stay cheerful. #ALS
One first decision after diagnosis was that I would continue: continue to work, continue to have fun, continue to laugh, continue to hope. Luckily I was always a person with a quite digital life. Using eye tracking you can still do a lot. Especially as a software developer.
Thorsten Wagner@thorstenwagner.bsky.social · 6mo agoIn September 2024, I was diagnosed with ALS. Today, I can no longer speak, I am confined to a wheelchair, and I can no longer move my arms. It's really shitty. I will write here soon about how I am coping with this and how I am trying to stay cheerful. #ALS
In September 2024, I was diagnosed with ALS. Today, I can no longer speak, I am confined to a wheelchair, and I can no longer move my arms. It's really shitty. I will write here soon about how I am coping with this and how I am trying to stay cheerful. #ALS
In September 2024, I was diagnosed with ALS. Today, I can no longer speak, I am confined to a wheelchair, and I can no longer move my arms. It's really shitty. I will write here soon about how I am coping with this and how I am trying to stay cheerful. #ALS
My first post on this forum! 😄 I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... Big thanks to my amazing colleagues in Dortmund
#BIAToolTip No.7 The Ridge Detection plugin from @thorstenwagner.bsky.social is really nice tool gem to automatically detect line-like structures in regular sized images in 2D/3D. Even though, not actively maintained anymore, it runs stable and does what it should.
Ridge Detection
The ImageJ wiki is a community-edited knowledge base on topics relating to ImageJ, a public domain program for processing and analyzing scientific images, and its ecosystem of derivatives and variants...
imagej.net
Oh wow, this is BIG: #MotionCor3 and #AreTomo2 for #cryoEM single-particle analysis and #teamtomo are now open-source!! Thank you Shawn Zheng and colleagues at the Chan Zuckerberg Imaging Institute. #OpenSoftwareAcceleratesScience github.com/czimagingins...
Together with Stefan Raunser, I wrote a little review on neurotoxic insecticides acting on ion channels. We focus on structures and mechanisms and try to reveal similarities in modes of action between chemically diverse compounds. In the end, many act surprisingly similar! rdcu.be/doHyK
