One cell, one tomogram! Our montage tomography workflow, MOSAIC, is out in Structure, and MontageMaker is on GitHub! MOSAIC: www.cell.com/structure/fu... MontageMaker: github.com/MPI-Dortmund... Big thanks to @maikaboiero.bsky.social, Adriana Prajica, Gavin Rice, and @raunser-lab.bsky.social!

Will you be our next junior group leader? Check out how Natalie Scholes, Gordie Watt and @woutoosterheert.bsky.social experience starting their groups at the Netherlands Cancer Institute. Apply before August: www.nki.nl/news-events/... #Vacancy #JuniorPI #ResearchOpportunity #NKI #EarlyDetection

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...

In September 2024, I was diagnosed with ALS. Today, I can no longer speak, I am confined to a wheelchair, and I can no longer move my arms. It's really shitty. I will write here soon about how I am coping with this and how I am trying to stay cheerful. #ALS

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

33 million euro investment for national electron microscope facility EMPower

A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...

uu.nl

Are you excited to uncover the molecular mechanisms of actin filament assemblies that drive cell migration using cryo-EM? Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...

PhD Student – Structural Biology of Actin Filament Assemblies | Werken bij AVL

werkenbijavl.nl

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social. www.sciencedirect.com/science/arti... Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 pubmed.ncbi.nlm.nih.gov/41075793/ #cryoEM

We just published this paper of which I am immensely proud: www.nature.com/articles/s41... In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of. Let's dive in... 🧵

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

nature.com

Thrilled to announce that from tomorrow (October 1st), I'll start as a junior group leader at the Netherlands Cancer Institute (NKI) @nkinl.bsky.social in Amsterdam 😄. www.nki.nl/news-events/... 1/3

Featuring #AlphaBridge features from @alvarezsalmoral.bsky.social, with @jonasteuwen.bsky.social and team, our new work from @nkinl.bsky.social nl.bsky.social @oncodeinstitute.bsky.social . Have a look at ahmpc.eu for more!

bioRxivpreprint@biorxivpreprint.bsky.social · 11mo ago

Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC) https://www.biorxiv.org/content/10.1101/2025.09.09.675133v1

Nature research paper: Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases go.nature.com/3HpdTqq

Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases - Nature

Structural insights into ultrafast Ca2+ transport by plasma membrane Ca2+-ATPases are provided, highlighting an essential role for PtdIns(4,5)P2 dynamics.

go.nature.com

Happy to have made a tiny contribution to this work (including the shown movie 😄). Amazing work by Fakler lab @uni-freiburg.de and @raunser-lab.bsky.social @mpi-dortmund.bsky.social about Ca-ion transport by PMCA2-NPTN complexes, now out in @nature.com www.nature.com/articles/s41...

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h

Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature

Afadin strengthens adherens junctions by stabilizing cadherin-catenin complex clusters on curved F-actin.

bit.ly

Working on actin cytoskeleton and Arp2/3 complex? Check out our latest work～https://www.biorxiv.org/content/10.1101/2025.01.31.635869v1 In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3

Michael Way@drmichaelway.bsky.social · 2y ago

Arp2/3 nucleates bidirectional linear actin filaments when activated by SPIN90 !!! www.biorxiv.org/content/10.1...

My first post on this forum! 😄 I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... Big thanks to my amazing colleagues in Dortmund