Check out our new @romagnanilab.bsky.social website: www.romagnanilab.com including an interactive portal for some of our datasets 🔍 Created by talented PhD candidate Oliver Knight @immunoliver.bsky.social

Romagnani Lab | ILC & NK Cell Immunology Research Berlin

We study the basic mechanisms of cellular adaptation at the single-cell level, investigating how innate lymphoid cells (ILCs) and natural killer (NK) cells shape immunity at Charité and DRFZ Berlin.

romagnanilab.com

@biorxivpreprint.bsky.social selective upregulation of XCL1 by activated NK cells is accompanied by the synovial enrichment of XCR1+ cDC1, directly correlating with disease severity #JIA @romagnanilab.bsky.social @drfzberlin.bsky.social @timorckert.bsky.social www.biorxiv.org/content/10.6...

Excited to share my paper published today in @cp-immunity.bsky.social! We find that when CTLs integrate antigen and cytokine signaling, the timing of these cues matters - shedding light on an old question: Why do NK cells sometimes behave like CD8+ T cells? www.sciencedirect.com/science/arti...

Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes

Lymphocyte differentiation during infection depends on the integration of antigen and cytokine signals, yet how the timing and sequence of these cues …

sciencedirect.com

Less than one week left to apply 🔜

Romagnani Lab@romagnanilab.bsky.social · 9mo ago

Join us at Charité University and the IMPRS-IDI Graduate Program in Berlin to unravel NK cell clonality and memory! We are looking for motivated PhD candidates who are passionate about immunology. @romagnanilab.bsky.social @timorckert.bsky.social Apply now 👉 www.imprs-idi.org/home/

We are looking for motivated PhD candidates to study NK cell clonality and memory :) Apply by December 10

Romagnani Lab@romagnanilab.bsky.social · 9mo ago

Join us at Charité University and the IMPRS-IDI Graduate Program in Berlin to unravel NK cell clonality and memory! We are looking for motivated PhD candidates who are passionate about immunology. @romagnanilab.bsky.social @timorckert.bsky.social Apply now 👉 www.imprs-idi.org/home/

You like engineering T cells, but you are missing the right flavor? Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1 We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt 𝐏rogrammable 𝐀nd 𝐒ite-specific 𝐓ransgene 𝐀ddition 🧪

Versatile and efficient non-viral integration of large transgenes in human T cells via CRISPR knock-in and engineered integrases

Current gene transfer methods often lack the precision, versatility, or efficiency when integrating large transgenes, limiting the ability to engineer therapeutic T-cells with more complex payloads. H...

biorxiv.org

Must read! Super exciting work and innovative approach.

Caleb Lareau@caleblareau.bsky.social · last yr.

Excited to share a new preprint from the lab with @ryandhindsa.bsky.social ! www.biorxiv.org/content/10.1... Led by @sherrynyeo.bsky.social, @erinmayc.bsky.social, and friends, we continue our journey to find viral DNA in our favorite place-- the overlooked and discarded reads in existing data! 1/

Trying a slightly new model (for us at least) of #openscience. With @ronanchaligne.bsky.social and @karolisk.bsky.social, we pitted 10x Genomics Chromium GEM-X against Illumina PIPseq V head-to-head to understand these two platforms for single-cell genomics. Some thoughts off the bleeding edge: /1

a baby is eating a piece of food while sitting on the ground .

ALT: a baby is eating a piece of food while sitting on the ground .

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Happy to share that the preprint to our new scATAC-seq multiplexing method, MULTI-ATAC, is officially online: www.biorxiv.org/content/10.1...

Reducing batch effects in single cell chromatin accessibility measurements by pooled transposition with MULTI-ATAC

Large-scale scATAC-seq experiments are challenging because of their costs, lengthy protocols, and confounding batch effects. Several sample multiplexing technologies aim to address these challenges, b...

biorxiv.org

Bluetorial: Avoiding becoming et al. I decided not to do a postdoc with a Nobel laureate for personal reasons, but this decision had unanticipated benefits for my career.

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

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💥💥💥 !!! Please re-post !!! 💥💥💥 Hello Community, We’re excited to announce that we’re moving to Groningen in January 2025 to embark on a new chapter in our research careers. For this, we need a house/flat and we hope to find a nice place with your help.

I'm incredibly honored to have received this recognition. A heartfelt thank you to everyone involved in making the evening so special :)

Romagnani Lab@romagnanilab.bsky.social · 2y ago

Huge congratulations to @timorckert.bsky.social on receiving the Pettenkofer Prize for our work on human NK cell memory and clonality! A heartfelt thank you to Oliver Keppler and the Pettenkofer-Stiftung for the warm welcome and the wonderful ceremony!

A short intro to the many new followers gained at 🦋: 🧪🔬we are a diverse team of researchers driven by curiosity, dedicated to understanding immune regulation in disease & cancer & exploring new strategies for immunotherapies 🩺⚕️ ❤️ all things spatial; DCs, T cells, NK cells & single cell analyses.

To introduce myself and what I do: in my PhD @romagnanilab.bsky.social, I found that human NK cells maintain clonal immune memory to CMV infection www.nature.com/articles/s41...

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory - Nature Immunology

Here, the authors use single-cell multiomics and profiling of mitochondrial mutations as endogenous barcodes to show that human adaptive NK cells induced by CMV persist as clonal expansions that inher...

nature.com

To populate my Bluesky and people know what I do: I am an MD turned immunology "basic" researcher. In the past I did adoptive T cell therapy and then fate mapping in the Buchholz lab in Munich: CD8+ T cells in MCMV: www.nature.com/articles/s41...

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection - Nature Immunology

T cell memory formation is often described as occurring during the chronic phases of infection. Buchholz and colleagues use the phenomenon of ‘memory inflation’ following cytomegalovirus infection to ...

nature.com

🚨 We’re hiring! 🚨 Join the Gaebler & Ibrahim Labs for an exciting postdoc position at the intersection of virology & gene regulation! Help us uncover mechanisms behind HIV latency using cutting-edge genome engineering. More info: www.nature.com/naturecareer...

Postdoctoral Scientist (d/f/m) in Life Sciences/Genetics - Berlin (DE) job with Berlin Institute of Health in der Charité (BIH) | 12831190

The mission of the Berlin Institute of Health at Charité (BIH) is medical translation: transferring biomedical research findings into novel approac...

nature.com