I had the pleasure of presenting concepts of T cell immunity and our work on cancer immune evasion at the @dgfi-org.bsky.social Spring School in Ettal, Bavaria. Inspiring talks & great exchanges with talented junior researchers across Germany—thank you for the invitation! #dgfispringschool

Excited to share our new collaborative study with the Sebastian Kobold lab! www.nature.com/articles/s41... By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.

Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours - Nature Biomedical Engineering

Targeted ablation of prostaglandin E2 (PGE2) signalling in CAR T cells enhances their activity in PGE2-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-...

nature.com

Thrilled to share that my #ERCCoG EICO-CODE has been selected for funding!🚀 We will study how eicosanoids shape T cell immunity across tissues. 🧬🔬🧪✨ I am deeply grateful for this recognition of the team’s work - and to everyone supporting us in our research. Exciting years ahead!

Less than one week left to apply 🔜

Romagnani Lab@romagnanilab.bsky.social · 9mo ago

Join us at Charité University and the IMPRS-IDI Graduate Program in Berlin to unravel NK cell clonality and memory! We are looking for motivated PhD candidates who are passionate about immunology. @romagnanilab.bsky.social @timorckert.bsky.social Apply now 👉 www.imprs-idi.org/home/

Very happy to join the team of the CRC 1479 initiative for the 2nd funding period to study mechanisms of immune evasion in cancer! www.sfb1479.uni-freiburg.de/news/great-n...

🚨Our lab has a new review article out today! We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies. Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social 🔗 doi.org/10.1182/bloo...

Prostaglandins in cancer revisited: principles of production, mechanisms of immune regulation, and therapeutic perspectives

The cyclooxygenase (COX) signaling pathway is frequently dysregulated in cancer, resulting in aberrant production of prostaglandins - a distinct class of b

doi.org

Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e www.nature.com/articles/s41...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells

Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....

rdcu.be

Wonderful to see Klaus Rajewsky honored with the first ever EFIS Lifetime Achievement Award! #iIUIS2025 in Vienna.

🍾Many congratulations to former PhD student Philippa Meiser - now Postdoc with Laura Mackay @thedohertyinst.bsky.social - for receiving this years PhD award 🥇 from @dgfi-org.bsky.social at @iuis-online.bsky.social !

Interesting study by @reisesousalab.bsky.social, highlighting functionally distinct states of activated cDC1s in tumors. 🔬🧪

Caetano Reis e Sousa@reisesousalab.bsky.social · last yr.

Delighted that our paper describing cDC1 states and their distribution in mouse tumours is out today in @eurjimmunol.bsky.social. Many congratulations to Cécile Piot who led this work and brought it to conclusion! onlinelibrary.wiley.com/doi/10.1002/...

Looking forward to great talks and discussions with friends and colleagues in London👇!

Pallett Lab UCL@pallettlab.bsky.social · last yr.

#Immunologists - have you signed up for BSI's @london-immuno.bsky.social 1d conference yet? Fri 11th July Speakers include: Jan Böttcher, Tao Dong, @labliston.bsky.social, @beecell.bsky.social, Claudia Mauri & Claire Malone REPOST to share as widely as poss www.immunology.org/events/diver...

🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues. 📍 Where: Basel, Switzerland 📅 When: 26th–29th August 2025 📝 Registration deadline: 30th May 2025 Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social #EMBOBarrierTissues

Adaptive immunity in barrier tissues

Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

meetings.embo.org

thrilled to share that I’ve officially been appointed as Professor of Experimental Immunology @unituebingen.bsky.social, with the lab based at both the M3 Research Center and the Institute of Immunology, continuing interdisciplinary and translational research in cancer and tissue immunology 🧪🧫🧬🔬

📣 !! JOB ALERT for PhD students !! My lab is moving to the M3 Research Center at the University of Tübingen and is looking for PhD students who are enthusiastic about translational research. If you are, read on below ⬇️

We're hiring at all levels! Feel free to reach out if you have questions: academicjobsonline.org/ajo/jobs/29722

Unsere Recherchen zu den Auswirkungen des US-Hilfsstopps sind heute bei Zeit Online nachzulesen mit Stimmen aus den USA, Kenia, Thailand, Südafrika und dem Sudan: #USAID #PEPFAR www.zeit.de/gesundheit/2...

USAid: Die Zerstörung hat schon begonnen

Ob Projekte gegen HIV, Malaria oder vernachlässigte Tropenkrankheiten: Die USA streichen ihre medizinische Entwicklungshilfe. Die Folgen sind schon jetzt dramatisch.

zeit.de

„Anyone who has studied science under the Nazis, as I did for my book Serving the Reich, cannot fail to be dismayed and alarmed at the parallels in the response so far of scientific institutions and academies to the purges and abuses of power following Trump’s executive orders“ 🧪

Scientific institutions have a long history of anticipatory obedience

Societies should learn from this and speak up to support inclusion

chemistryworld.com

NIH has cut billions of dollars in biomedical funding, effective immediately The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease. www.washingtonpost.com/health/2025/...

NIH cuts billions of dollars in biomedical funding, effective immediately

The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

washingtonpost.com

Some learnings about our immune system from Covid @nature.com —importance of T cells (not just neutralizing antibodies) —key role of interferons, the first line of defense —hybrid immunity —underpinnings of Long Covid www.nature.com/articles/d41...

Four lessons COVID taught us about the immune system

In the midst of pandemic upheaval, researchers have gained fundamental insights about how the body fends off infections.

nature.com

Join the next #globalimmuno talk this Wednesday, January 15th, at 9 am PST, 12 Noon EST, 4 pm GMT featuring AAI Member Jenny Ting! We look forward to hearing many more impactful Global ImmunoTalks from other AAI members in 2025. ucsd.zoom.us/j/91053505061

🧪 elegant study using rabies-based retrograde tracing to map and manipulate GBM-neuron networks. www.cell.com/cell/fulltex...

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.

cell.com

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS go.bsky.app/QSEPDoj

Rod Rahimi@rodrahimi.bsky.social · 2y ago

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network Below are the links If you're an immunologist and I have missed you so far, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS

🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social

Anna Obenauf@obenaufa.bsky.social · 2y ago

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

🧪Exciting read on the role of dendritic cells supporting CAR T cells in tumors 👇 www.biorxiv.org/content/10.1...

Both #Cancer #Research starter packs are now completely full! ~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️ I hope you'll find these useful to build our community here Pack 1: go.bsky.app/FEoaJMc Pack 2: go.bsky.app/6EcjWNA

Vaccines save lives and reduce health care costs. Those are facts.“ www.nytimes.com/2024/11/20/o...

Opinion | What R.F.K. Jr. Might Do on Vaccines

As the nation’s top health official, he could discourage vaccine research and production, and dissuade Americans from getting shots.

nytimes.com

Pls share 🌟Join the IMP as a Group Leader We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social 👉https://tinyurl.com/impgl2025

🧪 A pathogenic interplay between CD103+ CTLs and X-presenting macrophages in the liver limits the efficacy of ICB treatment against HCC. dlvr.it/TGGwVv

Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma

Whether cytotoxic T lymphocytes (CTLs) exert protumorigenic effects remains elusive. Huang et al. reveal that macrophages cross-present to clonally expanded CD103+ CTLs in the pericancerous area in he...

dlvr.it

A short intro to the many new followers gained at 🦋: 🧪🔬we are a diverse team of researchers driven by curiosity, dedicated to understanding immune regulation in disease & cancer & exploring new strategies for immunotherapies 🩺⚕️ ❤️ all things spatial; DCs, T cells, NK cells & single cell analyses.