Extremely happy to receive the 2024 Denise Barlow Award for my PhD work. Grateful to my mentor @obenaufa.bsky.social and the entire Obenauf lab, all collaborators, and the award committee for this recognition!

CeMM@cemm.oeaw.ac.at · 11mo ago

🎉 Congrats to @aelewaut.bsky.social for winning the 2024 #DenisePBarlowAward! 🎖️ She carried out her PhD thesis in @obenaufa.bsky.social's lab (@impvienna.bsky.social), work published in @nature.com. 📄 Paper: rdcu.be/eQv1f ➡️ About the award: bit.ly/3iFbafP

Congratulations to Anais Elewaut, former PhD student in Anna Obenauf’s lab, who was awarded the Denise P. Barlow Award for her exceptional doctoral research on how tumours evade the immune system. More: www.imp.ac.at/news/article...

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP www.science.org/doi/10.1126/...

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...

science.org

The new CRISPR-StAR tool by @ulielling.bsky.social and team provides elegant new opportunities for in vivo screens. Glad we @aelewaut.bsky.social could contribute a bit.

Ulrich Elling@ulielling.bsky.social · 2y ago

Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology. 1/ www.nature.com/articles/s41...

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz

A lipid made by tumour cells reprograms immune cells

Insights into how cancer cells become unresponsive to therapy.

nature.com

🧪Cross-Dressing intratumoral monocytes fulfill the job of cDC1s in supporting tumor-infiltrating CD8 T cells in their anti-cancer functions. Great to have contributed some 🔬&🧫 to this tour de force study by @obenaufa.bsky.social

Anna Obenauf@obenaufa.bsky.social · 2y ago

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Cancer cells blunt monocyte IFN while increasing PGE2 to inhibit T cell immunity @obenaufa.bsky.social @aelewaut.bsky.social @guillemxtivill.bsky.social www.nature.com/articles/s41...

Extremely excited to see my PhD work in the @obenaufa.bsky.social published today in @natureportfolio.bsky.social 🤩. A big thank you to everyone who contributed, special thank you to my partner in crime @guillemxtivill.bsky.social - it was a lot of fun to work on this together! 🥳

Anna Obenauf@obenaufa.bsky.social · 2y ago

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

#Immunotherapy has transformed #cancer treatment, but some cancers evade immune defenses, causing resistance. @obenaufa.bsky.social's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors. Read more: imp.ac.at/news/article...

Super talk at #EMDS2024 by Anna Obenauf on myeloid cell hubs for T cell interactions in cancer 👏 And this is coming out in Nature 🧪 in just a few hours - congrats to Anais, Guillem, Anna & all authors 🥳🎉 @aelewaut.bsky.social @guillemxtivill.bsky.social @obenaufa.bsky.social @impvienna.bsky.social

Dendritic cells maintain the CAR T cell pool in irradiated tumors www.biorxiv.org/content/10.1...