SMT
@pp0196.bsky.social
Sequences and consequences. Credit Pic : Cellular landscape cross-section through a eukaryotic cell, by Evan Ingersoll
Quack, quack! A DuckDB v2.0 preview is here! 🦆 In this post, #DuckDB co-creators Mark Raasveldt + @hannes.muehleisen.org preview the headline features of DuckDB v2.0 (expected to land this autumn): • DuckDB as a server • Triggers • async I/O • + more Dive into the deets: duckdb.org/2026/08/17/d...
Can databases scale scientific analyses beyond RAM? I’m excited to share dbverse, a composable database framework built to do just that. Across benchmarks, dbverse delivers ~1000x speedups and scales #spatialomics analyses to millions of cells. Preprint: www.biorxiv.org/content/10.6... 1/🧵
dbverse scales spatial omics analysis with embedded analytical databases
Spatial omics datasets are increasing in size and complexity, exceeding the memory of standard computers and thereby limiting data analysis. Here we present dbverse, a framework for larger-than memory...
biorxiv.org
diffuseR is on CRAN! AI images and video, locally in #rstats install.packages("diffuseR") Go make something weird!
No matter how much one tries, LLMs cannot stop generating disgusting #Rstats code (1K .something functions checking if string is empty or similar) and i think this is getting worse. No wonder people do not want to read code anymore or prefer using slop language they don't know to read
CRISPR off-target search can find the right locus while hiding plausible alignments within it. I wrote about how Sassy v0.2.5 uses recursive backtracking to report every reasonable alignment—more than 9× as many in under 30 seconds. blog.fulcrumgenomics.com/p/why-crispr...
Why CRISPR Off-Target Search Should Report Multiple Alignments Per Locus
How Sassy enumerates every reasonable alignment without sacrificing runtime
blog.fulcrumgenomics.com
Even though i am a user of slopware, i thing the #Bioinformatics field needs a declaration like this leidendeclaration.ai
Leiden Declaration on Artificial Intelligence and Mathematics
This declaration calls for action to address the challenges posed by the use of artificial intelligence within mathematics research.
leidendeclaration.ai
#RStats is this SSL issue on cran.r-project.org/submit.html restricted to me or others are facing the same issue ?
#Rstats ah looks like CRAN fedora machine's tool chain got updated, and lot of C code nonsense in the vendored libraries my packages wrap are not allowed anymore. Good though that there are 25 other packages concerned :D I have on month to fix it or packages will be rightfully boot out
best way to send a LLM into a loop and burn all your tokens, in #RStats/C project, say go look at @coolbutuseless.bsky.social repos github.com/coolbutusele... for what we can use
coolbutuseless - Repositories
Cool, but useless. coolbutuseless has 255 repositories available. Follow their code on GitHub.
github.com
CRAN release of version 1.4.0-0.1.0 of Rduckhts, the #RStats It was also nice to confirm that are our port of Brent Pedersen 's great mostdepth algorithm is likely the fastest for that application space in the West. But riker shows us there is space for memory bounding !
My secret 4th ALGO paper is out! We show a tight space lower on non-minimal k-perfect hash functions, generalize PtrHash into a non-minimal k-PHF, and then use it to develop a hash set implementation that is up to 1.6x faster than other hash sets! With Stefan {Hermann, Walzer} and Peter Sanders
arXiv cs.DS Data Structures and Algorithms@csds-bot.bsky.social · last mo.Ragnar Groot Koerkamp, Stefan Hermann, Peter Sanders, Stefan Walzer: Non-minimal k-perfect hashing: Tight lower bounds and an application to fast static hash tables https://arxiv.org/abs/2607.07257 https://arxiv.org/pdf/2607.07257 https://arxiv.org/html/2607.07257
ggmlR from Yuri Baramykov is a great #RStats package, i re-use the big work of the selective ggml build infra for the related Rfmalloc Project ggmlR: github.com/Zabis13/ggmlR Rfmalloc monorepo : github.com/sounkou-bioi...
This is for the real lovers of esoterica RSTT: Work-in-progress set-theoretic type algebra for the R language by Mickaël Laurent #RStats, #OCaml, #C API, Programming language theory and set theory repo : github.com/E-Sh4rk/rstt/ with a REPL !
My day job is to conduct statistical analysis of omics data, and most of it is spent writing R. In this new blog post, I share the R package shape I reached for in my recent projects. mickael.canouil.fr/posts/2026-0... #RStats #Shiny #Quarto #OpenSource #DataScience
since i am doing lot of pi based vibesloping these days and R markdown is my testing framework, made piknit #RStats package with Slope Code for a coming work github.com/sounkou-bioi...
cited Marx one time in a session, and now Slope Code autocompletes "idealist" at each new concepts "discovery". Below i suggest let's see what are the lazy eval/effect type of libraries in the Typescript (for my own culture) world just like in #RStats : --->Idealist
‼️Big package update on CRAN! #raymolecule v0.9.0 brings ribbon diagrams! Grab PDB files directly from the RCSB Protein Data Bank with just their PDB ID and render it in #RStats with #rayrender or #rayvertex: it's that easy! read_pdb("2w5o") |> generate_ribbon_scene() |> render_model()
Now you can use your Claude or ChatGPT subscription to run the R agent harness, corteza. No API key, no per-token meter, and it's on CRAN! Thanks to @hadley.nz for the provider-native search idea, and to @pp0196.bsky.social, whose Codex OAuth PR became tinyoauth. cornball.ai/posts/claude...
Claude and Codex subscriptions, now driving an R agent
A couple of months ago, corteza was an R session you could hand to an LLM, as long as you fed it an API key and watched the per-token meter tick. As of this week you can point it at your Claude Pro/Ma...
cornball.ai
New release of secretbase 1.3.0 - a cryptography and data encoding toolkit. Adds base64 URL-safe variants. This is in addition to sha256, sha3, shake256, keccak, siphash, base58, cbor, json etc. all in 40kB. This package provides secure hashing for {targets}. #Rstats github.com/shikokuchuo/...
GitHub - shikokuchuo/secretbase: secretbase - Cryptographic Hash Functions and Data Encoding
secretbase - Cryptographic Hash Functions and Data Encoding - shikokuchuo/secretbase
github.com
#Rstats package update: zip 3.0.0 with some very cool new things: password protected zip files, vectorized and concurrent unzip(), unzip over HTTP, progress bars. Full change log at github.com/r-lib/zip/re...
Releases · r-lib/zip
Platform independent zip compression via miniz. Contribute to r-lib/zip development by creating an account on GitHub.
github.com
I’m excited to announce that #codex is now available (typically through a chatGPT subscription) from R through corteza. Logging in is enabled by the dev version of the new tinyoauth package, already in the CRAN queue! A big thank you to @pp0196.bsky.social for the contribution.
Beware #Rstats users, according to Misanthropic, an R to C transpiler is a security risk 😄 Fable turned out to as expected to be La Fable I think some french speaker at Misanthropic is doing some kind of joke with these model names
Rbebelm: #RStats Bindings for 'BebeLM' 'CPU' Inference For A 8B-1B Active model, not that bad A tiny R CLI "Agent" inspired by Corteza github.com/cornball-ai/... repo: github.com/sounkou-bioi... Upstream Rust crate : github.com/maximecb/beb... LFM2.5-8B-A1B blog: www.liquid.ai/blog/lfm2-5-...
RsimdDispatch: Runtime 'SIMD' Dispatch Templates for 'C' Code in #RStats Packages hellorust.multiversion: Minimal Rust SIMD Multiversioning Example for #RStats A way to enjoy both Linux binary Packages and Optimized code at runtime. github.com/sounkou-bioi... github.com/sounkou-bioi...
Our medRxiv preprint is out: Automated versus manual reanalysis in rare disease genomics. We reanalysed 377 rare disease cases from a routine diagnostic genome sequencing cohort, comparing the established manual workflow with Talos-based automation. www.medrxiv.org/content/10.6...
medrxiv.org
We conducted the most extensive systematic GWAS gene prioritisation to date across all openly available data, with a retrospective analysis of 100,526 GWAS over the past decade: www.biorxiv.org/content/10.6...
biorxiv.org
Rducks: Register arbitrary #Rstats User-Defined Functions in duckdb-r (1.5.2) including (sacrilege) distributed chunk execution mode via #mirai+libnng. Arrow C Data marshaling dance that that may be removed later. Trivial #duckplyr integration. Stream DuckDB queries repo: github.com/sounkou-bioi...
