Our Sept cover shows a mouse pancreatic islet (alpha cells in pink & beta cells in blue), highlighting single cell calcium responses to stimuli. In this issue, Hart et al report that SST inhibits insulin secretion by restraining alpha cell calcium and cAMP link.springer.com/article/10.1...

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n

Hart et al show that somatostatin released by delta cells during nutrient stimulation mostly inhibits alpha cell cAMP and Ca2+ via SSTR2. This prevents glucagon release and indirectly limits potentiation of insulin release link.springer.com/article/10.1... 🔓

Somatostatin receptors shape insulin and glucagon output within the pancreatic islet in mice through direct and paracrine effects - Diabetologia

Aims/hypothesis Pancreatic delta cells secrete somatostatin (SST), which can inhibit both alpha cells and beta cells of the pancreatic islet. By controlling insulin and glucagon release, delta cells p...

link.springer.com

New paper in @diabetologiajnl.bsky.social on paracrine control of insulin secretion, led by the talented newly minted Dr. Ryan Hart (@ryanhart13.bsky.social). 1/5 doi.org/10.1007/s001...

Very proud to graduate the next group of supremely talented young Doctors from my UC Davis lab!! Dr. Mohammad Pourhosseinzadeh, Dr. Michelle Chan, and Dr. Ryan Hart. They each have published creative and impactful stories - much of it coming out soon. Stay tuned!! @ucdavis.bsky.social

We're ready for the Stand Up for Science on March 7 - Sacramento Capital - West Side. See you there!!!