Anthony Ramnauth
@philoneurosci.bsky.social
Postdoc - https://bsky.app/profile/lukesjulson.bsky.social @ Albert Einstein College of Medicine | Ph.D. JHU SOM - https://bsky.app/profile/martinowk.bsky.social @ LIBD.
This seems super important for in vivo experiments #Norepinephrine and #dopamine #sensor crosstalk depends on local innervation density doi.org/10.1038/s415...
Norepinephrine and dopamine sensor crosstalk depends on local innervation density - Nature Neuroscience
This study shows that GPCR-based norepinephrine and dopamine sensors display crosstalk in several brain areas. Relative innervation densities determine the extent of crosstalk, and loss-of-function co...
doi.org
New research out today! Some animals have three eyes?! This eye isn't for "seeing" per se, but it's connected to a part of the brain responsible for regulating body temperature. So if you see a lizard basking out in the sun to get warm, oftentimes this eye plays a central role. But there's more...
#Hippocampal #CA3 #connectomics reveals a gradient of #mossyfiber inputs and selective feedforward inhibition onto pyramidal cells doi.org/10.1038/s415...
Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells - Nature Neuroscience
The authors present a dense connectomic reconstruction of a 0.1 mm3 hippocampal CA3 volume and reveal spatial gradients, high convergence and cell-type-selective feedforward inhibition of inputs to py...
doi.org
A stock market is where shares in companies are bought and sold based on economic data such as “did the president say war words or peace words last night?” and “can you imagine a future where computers do all your work for you much better than you do would but you keep all the money?”
Truth API... WUT? MAGA really don't give a fuck how much crimes they commit, do they?
today in "headlines you'd see on a background TV in a disaster movie" www.bloomberg.com/news/article...
Rhine Falls to Lowest Since 1880, Disrupting European Trade
The Rhine River’s water levels dropped to the lowest in nearly 150 years as hot, dry weather grips Europe, threatening to disrupt a crucial route for transporting coal, fuel and industrial commodities...
bloomberg.com
He also has one of my favorite quotes: If one wishes to understand the behavior of animals, one must take account of their individuality, annoying as this may be for those who prefer the tidiness of physics, chemistry, and mathematical formulations. -Donald Griffin
Greg Priest@gregpriest.bsky.social · 2d agoDonald Griffin, discoverer of bat echolocation, was born OTD 1915. I imagine “small mammals enough like ourselves to feel that I could understand what their lives would be like, and yet different enough to make it a sort of adventure and exploration to see what they were doing.” 🐋🌱🧪 #HistSTM
"We demonstrate the precise photoactivation of spatial and temporal sequences of neurons in one or multiple cortical areas while reading out the downstream effects in several other regions." Probing inter-areal computations with a two-photon holographic mesoscope doi.org/10.1038/s41593-026-02350-9
Probing inter-areal computations with a two-photon holographic mesoscope - Nature Neuroscience
The authors developed a new microscope that can measure and manipulate brain activity across multiple brain regions simultaneously with high precision, enabling scientists to study how spatially distr...
doi.org
The final version of our amygdala dopamine paper is out! BLA dopamine dynamically tracks emotional salience and not value or reward prediction error. Congrats to Dr. Megan Brickner!! www.nature.com/articles/s41...
Basolateral amygdala dopamine transmits emotional salience - Nature Communications
The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...
nature.com
"...chromatin architectural changes in engram neurons occur over timescales of weeks and appear, in part, to repurpose conserved regulatory machinery to dampen the extent to which these neurons will engage in further information storage."
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 5d agoMemory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling https://www.biorxiv.org/content/10.64898/2026.07.29.741555v1
Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling https://www.biorxiv.org/content/10.64898/2026.07.29.741555v1
Synaptic engram underlies memory https://www.biorxiv.org/content/10.64898/2026.07.30.740767v1
Hunger neurons track available food locations during foraging and spatial memory recall https://www.biorxiv.org/content/10.64898/2026.07.28.741066v1
An end-to-end framework for single-cell-resolution, whole-transcriptomic spatial profiling in post-mortem human brain https://www.biorxiv.org/content/10.64898/2026.07.28.740610v1
A conserved population of genetically defined striatal neurons gates opioid reward https://www.biorxiv.org/content/10.64898/2026.07.28.741269v1
Bouquet of zebrafish nasal epithelium. Credit to @inyoungj88.bsky.social. #ZebrafishZunday #SciArt 🧪
Widespread influx of myeloid cells into the healthy human brain which contributes to the pool of human microglia and becomes common with aging @nature.com www.nature.com/articles/s41... @siddharth06.bsky.social @stanfordmedicine.bsky.social @howardychang.bsky.social @juliabelk.bsky.social
The COVID brain fog explained. The COVID-19 virus binds to the ACE2 receptor to enter cells. Dopamine producing neurons are rich in the ACE2 receptor. The virus causes disruption in the dopamine network in the brain. 🧪 tech-paper.com/scientists-f...
Scientists finally have a biological explanation for why long COVID patients lose motivation and can't think clearly. They scanned their brains and found the dopamine system was physically damaged - T...
Millions of people with long COVID report the same cluster of symptoms: a crushing lack of motivation, an inability to think clearly, memory that slips, movements that feel slower than they should. Fo...
tech-paper.com
The headlines are still covering the cyclosporiasis outbreak from lettuce, but let's talk about a different summer, long ago. The headlines in Bavaria would have called it "summer diarrhea" & it was killing babies. Enter our hero, Professor Theodor Escherich of the Julius Hospital, Würzburg.
A #cortical - #hypothalamic #neural #circuit for #compulsive eating in #mice: Neuron www.cell.com/neuron/fullt...
A cortical-hypothalamic neural circuit for compulsive eating in mice
Leow et al. identify a prefrontal-hypothalamic circuit that drives compulsive eating despite negative consequences. In mice, binge eating reshapes prefrontal neural dynamics into persistent food-seeki...
cell.com
Very cool paper systematically characterizing dopamine neuron development and striatal arborization in the mouse brain. www.sciencedirect.com/science/arti...
Single-neuron resolution mapping of dopaminergic connectivity across development, adulthood, and degeneration
Individual midbrain dopamine (mDA) neurons exhibit complex morphologies, a feature that may underlie their different functions and disease vulnerabili…
sciencedirect.com
Nature research paper: Photocatalytic water splitting by 2D polymer with out-of-plane carrier flow go.nature.com/3S3fGXi
Photocatalytic water splitting by 2D polymer with out-of-plane carrier flow - Nature
A strategy using polymeric carbon nitride crystals induces out-of-plane carrier migration by means of internal electric fields applied on facet-selective nanofilms placed on polymer photocatalysts, increasing the apparent quantum efficiency for overall water splitting.
go.nature.com
Spatial #atlas of the #human #brain #vasculature reveals specialized #cell ensembles: Cell www.cell.com/cell/fulltex...
Spatial atlas of the human brain vasculature reveals specialized cell ensembles
An integrative cell and spatial atlas defines the organizing logic of the adult human cerebrovasculature, providing a framework for studying how vascular cell states support brain function and shape n...
cell.com
#Representations of the intrinsic #value of #information in #mouse #orbitofrontal #cortex doi.org/10.1038/s415...
Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience
Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...
doi.org
Miniaturizing and modifying natural #proteins with #Raygun www.nature.com/articles/s41...
Miniaturizing and modifying natural proteins with Raygun - Nature
Probabilistic sequence encoding from language model embeddings within a generative AI framework enables protein miniaturization, modification and augmentation while maintaining native architectur...
nature.com
Proliferative Effects of the #Psychedelic N,N-Dimethyltryptamine ( #DMT ) in #Human #Neural #Stem #Cells pubs.acs.org/acncdm/artic...
Proliferative Effects of the Psychedelic N,N-Dimethyltryptamine (DMT) in Human Neural Stem Cells
Abstract. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) produces rapid antidepressant effects in preclinical and early clinical studies. Therap
pubs.acs.org
Ito & Morozov reveal that fear conditioning in mice triggers proximity-seeking toward a familiar partner. This social response requires the amygdala–hippocampus pathway and oxytocin signaling, and operates independently of freezing via a distinct circuit www.nature.com/articles/s41...
Proximity in mice induced by an auditory-conditioned stimulus - Neuropsychopharmacology
Neuropsychopharmacology - Proximity in mice induced by an auditory-conditioned stimulus
nature.com
New Yorkers: Tonight's forecast calls for potentially life-threatening flooding, especially for those living in basement apartments and neighborhoods that have flooded before.
***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social
Generative replay across hippocampal-neocortical circuits
To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...
biorxiv.org
