Check out our new review with @mfarjo.bsky.social on what we know about the functional and evolutionary consequences of virus-virus interactions within viral populations, out now in @annualreviews.bsky.social: www.annualreviews.org/content/jour... Hope you like it!

Heterogeneity and Collective Interactions Within Viral Populations

The existence of viruses as obligate intracellular parasites with high mutation rates sets them apart from other forms of life in fundamental ways. Frequent errors in replication and assembly processe...

annualreviews.org

Our review is online! It highlights practical AI tools, key methods, and curated resources (website: yiquan2.com/AI-Immunolog... ) to empower experimentalists. We believe that the synergy between AI and experimental innovation will be a crucial catalyst for advancing the field of immunology.

Trends in Immunology@cp-trendsimmuno.bsky.social · 5mo ago

Experimental immunologists in the era of artificial intelligence #immunology

Happy to see @joelrc.bsky.social's paper identifying cellular heterogeneity in basal OASL expression as a major determinant of interferon induction during influenza virus infection out in its final form: www.pnas.org/doi/10.1073/... Happy new year, hope everyone's 2026 is better than 2025!

Check out @lizthayer.bsky.social's new preprint exploring factors that influence cell-to-cell heterogeneity in interferon (IFN) induction potential!

bioRxiv SysBio@biorxiv-sysbio.bsky.social · 8mo ago

Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state https://www.biorxiv.org/content/10.64898/2025.12.09.693293v1

This preprint just came out. @wchnicholas.bsky.social and team reconstructed and tested the NJ Spike and found that it has the tightest ACE2 binding of any SC2 Spike ever measured. 2/ www.medrxiv.org/content/10.1...

This is wild. Remember the NJ crytic lineage? I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out. Some colleagues took me up on it. Guess what they found? 1/

Evolution of Ab cross-reactivity to influenza H5N1 NA: Isolation & characterization of protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas.bsky.social www.cell.com/cell-host-mi...

Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline

Lv et al. isolated a protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2. Along with structural an...

cell.com

excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social looking to hire 2 postdocs to join us in this endeavor. more details can be found here: sites.google.com/uw.edu/statp...

Evolution of Ab cross-reactivity to influenza H5N1 NA New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas.bsky.social www.cell.com/cell-host-mi...

Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline

Lv et al. isolated a protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2. Along with structural an...

cell.com

I'm thrilled to share that the oPool⁺ display is on the cover of this week's #ScienceTranslationalMedicine! We hope that the future use of this platform can accelerate antibody characterization, benefit therapeutic & vaccine development, and facilitate iterative refinements of antibody AI models.

Science Magazine@science.org · 11mo ago

Don't miss the new issue of #ScienceTranslationalMedicine! A clinical study in Nepal shows that waning immunity to Japanese encephalitis virus can worse the severity of dengue, a new platform leapfrogs laborious obstacles in antibody discovery, and more. https://scim.ag/47qcFpw

The labs of Krammer, @wchnicholas.bsky.social, Ellebedy et al. identify a neuraminidase-targeting human monoclonal antibody (mAb-297) induced by seasonal #influenza vaccination that broadly protects against multiple influenza A & B strains, incl. avian #H5N1. rupress.org/jem/article/...

Excited to share @joelrc.bsky.social 's new paper examining the factors underlying cell-to-cell heterogeneity in interferon induction during flu infection: www.biorxiv.org/content/10.1...

In this updated manuscript, now available on bioRxiv, we are excited to (re)introduce oPool+ display, a high-throughput cell-free platform that enables rapid synthesis and specificity characterization of natively paired antibodies at an unprecedented scale: www.biorxiv.org/content/10.1... (1/)

High-throughput synthesis and specificity characterization of natively paired antibodies using oPool+ display

Antibody discovery is crucial for developing therapeutics and vaccines as well as understanding adaptive immunity. However, the lack of approaches to synthesize antibodies with defined sequences in a ...

biorxiv.org

@joelrc.bsky.social 's paper on differences between the seasonal H1N1 and H3N2 lineages in their relative capacity to antagonize IFN induction and signaling at the single cell level is out now in PLOS Pathogens: journals.plos.org/plospathogen...

Seasonal influenza a virus lineages exhibit divergent abilities to antagonize interferon induction and signaling

Author summary Successful replication and transmission of influenza A viruses (IAVs) requires effective subversion of the innate immune response. We developed a new single cell method to examine the i...

journals.plos.org

We have an open faculty search for TWO positions in microbiology and virology at the University of Illinois! We have world class core facilities and a fantastic collaborative group of young faculty...you could be next! Please re-post/skeet!

Check out @joelrc.bsky.social 's new preprint examining how the seasonal H1N1 and H3N2 lineages of IAV differ in their ability to antagonize IFN induction and signaling, and how these phenotypes have evolved over decades of circulation in humans: www.biorxiv.org/content/10.1...

Seasonal influenza A virus lineages exhibit divergent abilities to antagonize interferon induction and signaling

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

Check out @tonyl1415.bsky.social 's new paper on how the evolutionary potential of the seasonal H1N1 HA gene is influenced by its interactions with neuraminidase! academic.oup.com/ve/article/1...

Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin

Abstract. The antigenic evolution of the influenza A virus hemagglutinin (HA) gene poses a major challenge for the development of vaccines capable of elici

academic.oup.com

Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin https://www.biorxiv.org/content/10.1101/2024.03.18.585603v1

Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin https://www.biorxiv.org/content/10.1101/2024.03.18.585603v1

The antigenic evolution of the influenza A virus hemagglutinin (HA) gene poses a major challenge for

biorxiv.org

Excited to announce a postdoc position in my group! 🦠📈🧪 Come help us understand variability in immune responses to influenza vaccination, especially repeat vaccination, using data from a randomized trial and more. Great collaborators, methods, and problem. cobeylab.uchicago.edu/p/join-us

Excited to *finally* have @mfarjo.bsky.social 's fantastic paper on SARS-CoV-2 within-host evolutionary dynamics during acute infection published at JVI: journals.asm.org/doi/10.1128/...