Thanks to @edelblumlab.bsky.social for being a wonderful mentor and to @saraalonsomera.bsky.social for being the best partner in crime since the very beginning! 🎓🔬🎉

Edelblum Lab@edelblumlab.bsky.social · last yr.

There are few things better than celebrating milestones with your wonderful mentees! Congrats to @saraalonsomera.bsky.social & @nbgolovchenko.bsky.social on their graduation today. These two started during #COVID lockdown, moved to #NYC and will have made lasting contributions to the #gdTcell field🤩

If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

biorxiv.org

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

two men are riding a bicycle with a basket on it .

ALT: two men are riding a bicycle with a basket on it .

media.tenor.com

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

science.org

Congratulations to Dr. Sara Alonso on a spectacular defense! 👏 🍾 Sara is a powerhouse of #gdTcell #immunometabolism data in the lab. We can’t wait to share the #preprint of her thesis work on #gdTcells and #microbiota with you later this week. @sinaiimmuno.bsky.social