We close out 2025 with a review by @ananya-p.bsky.social & @tingtingli1.bsky.social in @gutmicrobes.bsky.social discussing the influence of the #microbiota on #gdTcell compartments within the gut, since populations and function differ in the #epithelium and lamina propria. 1/n

It’s a #gdTcell flavored #MucosalMonday! @saraalonsomera.bsky.social & I chat about the magic of our favorite cell type and our recent paper elucidating the role of the microbiota in driving gd IEL regulatory function on this month’s @societymucosalimm.bsky.social podcast. @sinaiimmuno.bsky.social

Mucosal Immunology@mucosalimmunol.bsky.social · 9mo ago

It’s #MucosalMonday and time for the latest @societymucosalimm.bsky.social podcast episode! This episode features gamma delta T cell work in MI from @edelblumlab.bsky.social; and an interview with @ashu-mangalam.bsky.social on microbial dysbiosis during #MutlipleSchlerosis

@repdangoldman.bsky.social, please draw attention to & speak up against political appointees in place of civil servants for #NIH Institute Directors. This is just the next tactic to prevent us from making advances and curing disease. #standupforscience

Mark Histed@markhisted.org · 10mo ago

A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions. A bit of a video explainer here: 1/ 🧪

The Zwick Lab website is live! 🔬🌀🌈
Check out our research and team at www.zwicklab.org

Home - Zwick Lab

Our organs don’t just grow once – they grow with us. While some are more adaptable than others, many remodel throughout life to meet the body’s changing needs, from daily challenges to the extraordina...

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Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling in this work from @saraalonsomera.bsky.social @edelblumlab.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…

sciencedirect.com

So grateful for my time in the Edelblum lab and so excited for what's to come!

Edelblum Lab@edelblumlab.bsky.social · last yr.

With great joy, we celebrated @saraalonsomera.bsky.social’s last day in the lab and recent acceptance of her paper @mucosalimmunol.bsky.social! 🥳🍾 We wish her the best of luck as a postdoc at NYU working with @rkzwick.bsky.social, where we know she’ll make us proud 😍. #gdTcells #GIresearch #proudPI

Great night out at #NYC @crohnscolitisfdn.bsky.social #TakeStepsWalk with the lab! The Mount Sinai IBD Center raised almost $2,500 for #IBD research. Bonus: I met Blake Lively & Ryan Reynolds (both very nice) on the ferry ride home! @sinaiimmuno.bsky.social

Thank you to the organizers for inviting me to speak and for choosing me for this award! I had a lovely time in Toronto learning so much about my favorite cells ❤️ #gd2025

Edelblum Lab@edelblumlab.bsky.social · last yr.

Congrats to @saraalonsomera.bsky.social for receiving 2nd place for best talk at #gd2025! Thanks to the Toronto crew for a great meeting and we look forward to seeing you at #gd2027 in Wrocław, Poland 🇵🇱

As expected, #gd2025 is as delightful as ever! Glad I could bring Irving & @saraalonsomera.bsky.social to hang out with our #gdTcell crew including @sarinaravens.bsky.social, @coffeltlab.bsky.social, @immunowolf.bsky.social, and Julie Jameson 🤩 Miss you @lydialynch.bsky.social!

Congrats to @ananya-p.bsky.social on her outstanding Master’s defense on #gdTcell migration! 🍾🎉 We’re looking forward to another couple of years with Ananya as she takes on the new role of senior grad student @sinaiimmuno.bsky.social 😁

Thank you @edelblumlab.bsky.social for being an amazing mentor and thank you @nbgolovchenko.bsky.social for being the best colleague and friend I could have asked for 😊. These past 5 years have been incredible and I'm excited for what's to come!

Edelblum Lab@edelblumlab.bsky.social · last yr.

There are few things better than celebrating milestones with your wonderful mentees! Congrats to @saraalonsomera.bsky.social & @nbgolovchenko.bsky.social on their graduation today. These two started during #COVID lockdown, moved to #NYC and will have made lasting contributions to the #gdTcell field🤩

📣 New preprint drop! In #ScienceImmunology, we found that regulatory #CD39 γδ IELs are reduced in #IBD, now @saraalonsomera.bsky.social shows that gut #microbiota promote enhanced CD39 expression in γδ IELs through #TCR and IL-15 activation. #gdTcells #GIresearch #Gastrosky @sinaiimmuno.bsky.social

bioRxiv Immunology@biorxiv-immuno.bsky.social · last yr.

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling https://www.biorxiv.org/content/10.1101/2025.03.22.644616v1

If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

biorxiv.org

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

two men are riding a bicycle with a basket on it .

ALT: two men are riding a bicycle with a basket on it .

media.tenor.com

@sinaiimmuno.bsky.social just gained a rockstar #PhD student with the acceptance of @ananya-p.bsky.social! Come see why we’re so lucky that Ananya will be joining us for a few more years at the APS Summit. She’ll be presenting two flashtalks (#GIL Trainee Symposium & Forte) on #gdTcell #migration 😍

Congratulations to Dr. Sara Alonso on a spectacular defense! 👏 🍾 Sara is a powerhouse of #gdTcell #immunometabolism data in the lab. We can’t wait to share the #preprint of her thesis work on #gdTcells and #microbiota with you later this week. @sinaiimmuno.bsky.social