Heat dome hot out there 🥵

🚨Our work #ReScale4DL: balancing pixel and contextual information for enhanced bioimage segmentation, with @henriqueslab.bsky.social is out today!🚀 www.nature.com/articles/s41... ReScale4DL links key concepts in DL (receptive fields)+microscopy (resolution) so they can work #bettertogether😉 Threat👇

Yesterday Cherry Huang gave us a friendly reminder at our Seminar Series: your fixative is not an innocent bystander She did an amazing job “schooling” us how crosslinking chemistry alters biosensor localization in #chromatin #microscopy Great science, beautiful slides & impressive #scicomm skill

Yesterday Cherry Huang gave us a friendly reminder at our Seminar Series: your fixative is not an innocent bystander She did an amazing job “schooling” us how crosslinking chemistry alters biosensor localization in #chromatin #microscopy Great science, beautiful slides & impressive #scicomm skill

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)

My annual culinary tradition: once a year, in an airport somewhere around the globe, I have a surreptitious Big Mac. London. Lisboa. Sydney. Frankfurt. And now, Chicago. The Big Mac world tour continues. 🍔🌎

How do we watch chromatin make developmental decisions as neurons are still alive? Tomorrow I have a poster at the Neural Dev GRC. We engineered biosensors that visualize chromatin states inside live neurons. The next frontier isn’t more sequencing it’s watching chromatin biology unfold in 4D.

How do we watch chromatin make developmental decisions as neurons are still alive? Tomorrow I have a poster at the Neural Dev GRC. We engineered biosensors that visualize chromatin states inside live neurons. The next frontier isn’t more sequencing it’s watching chromatin biology unfold in 4D.

Newport, RI….classic lunch: Anthony’s Seafood Hot lobster roll

How long do polarity proteins and their partners survive as a neuron prepares to migrate? Liam Hallada has answers today at the Neural Development GRC poster 13. Using a HaloTag pulse-chase imaging strategy he maps protein stability with spatial resolution in and around cell adhesions!

I didn’t realize my resting heart rate had a vacation mode. Turns out it does. 🏖️⌚

Simple mathematics 1 + 1 = heavenly

Love me some Baixa

Proof that the sweetest part of Lisboa has Ecuadorian roots. 🍫🇪🇨 Do not miss it if you are on Rua da Praia in Baixa

Proof that the sweetest part of Lisboa has Ecuadorian roots. 🍫🇪🇨 Do not miss it if you are on Rua da Praia in Baixa

Cheers 🍻

Head in the clouds on the top of Madeira Island

Head in the clouds on the top of Madeira Island

So happy to share this angle of my postdoctoral work! The skin epidermis keeps on keeping on, even when we deplete a majority of dermal fibroblasts.

Journal of Cell Biology@jcb.org · 3mo ago

@isabella-gaeta.bsky.social, @shuangshuangdu.bsky.social, @valentatormenta.bsky.social et al. show that the epidermal stem cell layer retains its capacity for proliferation despite significant fibroblast depletion during both adult and neonatal stages in vivo. rupress.org/jcb/article/... #StemCells

What if you could watch chromatin change in live neurons…..IN REAL TIME?Share if this is your dream! My lab is making biosensors to make chromatin visible as neurons wire into circuits & are hiring an Associate Scientist to build, not just execute. Apply: stjude.wd1.myworkdayjobs.com/stjude/job/M...

What if you could watch chromatin change in live neurons…..IN REAL TIME?Share if this is your dream! My lab is making biosensors to make chromatin visible as neurons wire into circuits & are hiring an Associate Scientist to build, not just execute. Apply: stjude.wd1.myworkdayjobs.com/stjude/job/M...

Still one of the purest dopamine hits in science: Thank you for your submission. For one brief, beautiful moment… the paper is someone else’s problem. Reviewer 2 can cook me later🔥

Post-graduation jaunt through Santa Fe country. Beautiful enough to make you forget the altitude for a minute. Rattler skin reminder of who really runs the joint 😳

Post-graduation jaunt through Santa Fe country. Beautiful enough to make you forget the altitude for a minute. Rattler skin reminder of who really runs the joint 😳

Celebrating K1 graduating from college 🎉🥳👏🎊🙌🍾

Mind-blowing cell action alert! Watching vesicle cargo lanes light up like a @FedEx highway in real-time under the #microscope. Who knew that a home-brewed phosphatidic acid imaging probe would look so stunning in fibroblasts? Too late for #FluorescenceFriday but just in time for #MicroscopyMonday

Mind-blowing cell action alert! Watching vesicle cargo lanes light up like a @FedEx highway in real-time under the #microscope. Who knew that a home-brewed phosphatidic acid imaging probe would look so stunning in fibroblasts? Too late for #FluorescenceFriday but just in time for #MicroscopyMonday

Hey y’all 👋 repost magic appreciated. The Solecki lab is recruiting multiple postdocs at St. Jude for a chromatin imaging project at the edge of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis. Ever dreamed of touring chromatin like this? We CAN 🔥

Amazing opportunity to work with an incredible supportive mentor doing cutting edge imaging/cell biology/gene regulation/neurobiology. #ScienceJobs #Neurosky 🧠🧪

David Solecki@so-lets-kilab70.bsky.social · 5mo ago

Hey y’all 👋 repost magic appreciated. The Solecki lab is recruiting multiple postdocs at St. Jude for a chromatin imaging project at the edge of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis. Ever dreamed of touring chromatin like this? We CAN 🔥

I have had the privilege of watching this Lab grow from its inception in 2007 to the powerhouse it is today. If I could pick a spot to do good science and a mentor to navigate the postdoc phase of my journey, I'd be knocking on this door humbly asking David if I could be of service to the mission. 🧪

David Solecki@so-lets-kilab70.bsky.social · 5mo ago

Hey y’all 👋 repost magic appreciated. The Solecki lab is recruiting multiple postdocs at St. Jude for a chromatin imaging project at the edge of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis. Ever dreamed of touring chromatin like this? We CAN 🔥