Traffic Light Commentary—Src in the Upside Down: A Kinase Turned Inside Out

Just as Antelope Canyon transforms familiar rock into an unexpected hidden landscape, the topological inversion of Src reveals an unforeseen extracellular facet of kinase signaling in cancer. Antelop...

onlinelibrary.wiley.com

Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer | NEJM

Current therapies offer limited benefit for patients with previously treated metastatic pancreatic ductal adenocarcinoma (mPDAC). Aberrant activation of the RAS pathway is the key driver of PDAC, w...

nejm.org

Traffic Light Commentary—Src in the Upside Down: A Kinase Turned Inside Out

Just as Antelope Canyon transforms familiar rock into an unexpected hidden landscape, the topological inversion of Src reveals an unforeseen extracellular facet of kinase signaling in cancer. Antelop...

onlinelibrary.wiley.com

Global analysis of cancer cell responses to USP9X inhibition - The EMBO Journal

The ubiquitin-specific protease (USP) USP9X is a human deubiquitinase (DUB) with a large number of described targets and cellular roles. In cancer, USP9X is found as an oncogene or as a tumour suppres...

link.springer.com

Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression - Nature Communications

YAP is a key oncogenic driver that has long been considered undruggable. Here, the authors present the development of a nanobody-based bioPROTAC that efficiently degrades endogenous YAP, demonstrating...

nature.com

A Toolbox for Quantifying Nuclear and Nucleolar Protein Accumulation Using NLS and NoLS Fusion Reporters

Fluorescent proteins fused with nuclear (NLS) or nucleolar (NoLS) localization signals are commonly used for live assessment of protein accumulation in the nucleus and nucleolus. We present a standar...

onlinelibrary.wiley.com

The Lack of a COPII Cargo Receptor Erv14 Impacts Physiological Functions of the Vacuole in Saccharomyces cerevisiae

Loss of the cargo receptor Erv14 in Saccharomyces cerevisiae results in sensitivity to calcium, zinc, neutral extracellular pH, and elevated temperature. Furthermore, cells deleted in the ERV14 exhib...

onlinelibrary.wiley.com

Stem cell control in the lung by an autocrine injury-activated Igf complex

Stem cells proliferate after injury to repair damaged tissue, and chronic injury can promote cancer. However, the injury-activated signals and regulatory mechanisms, and their relationship to cancer, ...

science.org

Deltaviruses spread through a viral Trojan Horse

McKellar et al. have discovered that some satellite viruses act as the ultimate hitchhikers. They physically become a virus inside a virus, hiding within helper virus particles by hitching a ride as a...

cell.com

Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

This study describes the cell-type-specific lysosomal proteome across the major brain cell types and identifies SLC45A1 as a neuron-specific lysosomal sugar exporter linked to lysosomal storage diseas...

cell.com

Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons

Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is...

onlinelibrary.wiley.com

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature

Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...

nature.com

Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer

Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vi...

science.org

Ageing promotes metastasis via activation of the integrated stress response - Nature

Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...

nature.com

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

science.org

A lysosomal requiem for glioblastoma cells

Once viewed solely as degradative compartments, lysosomes shape cell fate through signaling, metabolism, and communication. In glioblastoma, their rew…

sciencedirect.com

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity - Nature

The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.

nature.com

The integrated stress response promotes immune evasion through lipocalin 2 - Nature

The transcription factor ATF4 and its effector lipocalin 2 (LCN2) have a key role in immune evasion and tumour progression, and targeting the ATF4–LCN2 axis might provide a way to treat several t...

nature.com

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer

How tumor cells overcome anti-tumor immune responses and drive cancer recurrence is not well understood. Yu et al. demonstrate how therapy-resistant breast cancer cells synthesize and secrete arachido...

cell.com

Meningeal blood vessel blockage enhances anti-glioblastoma immunity

Meningeal blood vessel blockage enhances anti-tumor immunity against GBM in preclinical models by expanding dural resident border-associated macrophages, which are equipped with an elevated antigen-pr...

cell.com

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation

Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...

science.org

IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation

Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)–mutant glio...

science.org

Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature

Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...

nature.com