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Elodie Lafont

@elodie-lafont.bsky.social

PhD in Oncology. Researcher (CRCN INSERM), Cancer research, Cell Biology, Cell Signalling, PTMs #WomeninSTEM @csignaling.bsky.social https://oss-clcc.univ-rennes.fr/ https://scholar.google.com/citations?user=2ZoLzg4AAAAJ&hl=fr ORCID 0000-0003-1978-749

28 Posts1195 Follower2012 Folgt
Elliott Lab@elliottlab.bsky.social · 2mo ago

Huge effort from the Lab into the mechanics of the mysterious #ubiquitin like protein FAT10 – taking structural snapshots of FAT10 activation by UBA6 and transfer onto UBE2Z plus really interesting insights into InsP6 regulating FAT10 conjugation pathways: www.nature.com/articles/s41...

Structural determinants for FAT10 activation and transfer from UBA6 to E2 enzymes - Nature Communications

Cryo-EM captures FAT10 activation and transfer from UBA6 to E2 UBE2Z, revealing FAT10 monopolises UBA6. Efficient transfer requires E2 engagement of both FAT10 UBL domains, particularly UBL2, and co-o...

nature.com

Nature Cell Biology@natcellbio.nature.com · 3mo ago

☕Bassot, Violy, Gorka, Cigalotto et al identify ERO1a as a mitochondria-associated membrane protein that regulates calcium flux and #mitochondria bioenergetics, which may be potentially targeted to inhibit #glioblastoma growth in vivo. www.nature.com/articles/s41...

ERO1a fosters glioblastoma aggressiveness and metabolic flexibility by regulating mitochondria-associated membrane dynamics - Nature Cell Biology

Bassot, Violy, Gorka, Cigalotto and colleagues identify ERO1a as a mitochondria-associated membrane protein that regulates calcium flux and mitochondria bioenergetics, which may be potentially targete...

nature.com

Elodie Lafont@elodie-lafont.bsky.social · 4mo ago

Delighted to share this Review on Ub and Ub-like modifications in the ER stress response, now out in @febsj.bsky.social. With @tonyavril.bsky.social and @mattlegallo.bsky.social from the PROSAC and @omics teams @csignaling.bsky.social. febs.onlinelibrary.wiley.com/doi/10.1111/... .

FEBS Press

Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome-associated quality control, and ER-associated degradation. Ubiqui...

febs.onlinelibrary.wiley.com

Elodie Lafont@elodie-lafont.bsky.social · 4mo ago

Glad to share this Viewpoint on Dual IRE1 targets, now out in @febsj.bsky.social. With @tonyavril.bsky.social, Eva Billat and Léane Legrand, from the PROSAC team @csignaling.bsky.social. febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press

IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts....

febs.onlinelibrary.wiley.com

Todd Douglas@apoptoddic.bsky.social · 5mo ago

Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.

The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology

Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...

nature.com

Rune Busk Damgaard@rbdamgaard.bsky.social · 8mo ago

This project started with confusion 🤔 www.nature.com/articles/s41... Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects. Neither LUBAC nor OTULIN had been linked to metabolic regulation. So where do these metabolic manifestations come from?

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Rune Busk Damgaard@rbdamgaard.bsky.social · 8mo ago

🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it? Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear. Our new paper in Cell Death & Differentiation uncovers one. 🧵👇 nature.com/articles/s41...

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · 9mo ago

New Online! The mechanistic basis and cellular functions of UFMylation

The mechanistic basis and cellular functions of UFMylation

Nature Reviews Molecular Cell Biology, Published online: 09 January 2026; doi:10.1038/s41580-025-00944-yUFMylation, a ubiquitin-like modification, regulates endoplasmic reticulum-associated ribosome quality control by conjugating UFM1 to the ribosomal subunit RPL26, preserving ribosome integrity under stress. This Review explores the structural basis of UFMylation and its emerging functional breadth, and it discusses putative UFMylation substrates.

dlvr.it

Hesso Farhan@hessofarhan.bsky.social · last yr.

The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs. rdcu.be/eHw46

Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control

Nature Cell Biology - Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth,...

rdcu.be