We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

NEW PREPRINT 🚨 Why does IBS pain persist? PRC’s Nestor Jimenez-Vargas and the Bunnett Lab uncover how PAR2 signaling from endosomes amplifies fleeting histamine signals to sustain colonic nociceptor hyperexcitability. www.biorxiv.org/content/10.6... @badrsokrat.bsky.social

Excited to share Bunnett lab's work on targeting compartmentalized GPCR signaling! Using endosome-accumulating nanoparticles, they selectively blocked intracellular PAR2, achieving complete, long-lasting pain relief in inflammatory disease models. www.pnas.org/doi/10.1073/...

Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia | PNAS

Although many internalized G protein-coupled receptors (GPCRs) continue to signal, the mechanisms and outcomes of intracellular GPCR signaling are ...

pnas.org

Excited to share that I participated in the Annual Molecular Pathobiology Innovative Research Symposium at NYU and received an award for my flash talk presentation: “Compartmentalized intracellular signaling of the prostaglandin EP4 receptor contributes to pain.” #research #GPCR #pain #science

PRC Journal Club! #FlashbackFridays Flash back to earlier this week to a really interesting discussion led by @badrsokrat.bsky.social on endosomal signaling in opioid receptors. Click the article below to join the discussion. www.biorxiv.org/content/10.1...

PRC Highlight: Thank you to the Molecular Pathobiology for hosting the Birthday Tea Time #Partaayyy! Happy Birthday 🎉🎁🎈🎊🎂 @taeseonwoo.bsky.social @badrsokrat.bsky.social @tonelloraquel.bsky.social !!! #PRC #Painresearchcenter #boomerang ☕️🫖