Fascinating new work shows that satellite glial cells, not neurons, are the source of tonic GABA in the DRG! Satellite glia synthesize and release GABA, activating extrasynaptic GABA-A receptors to tonically temper sensory neuron excitability. pmc.ncbi.nlm.nih.gov/articles/PMC...

Congratulations to PRC director Dr. Kara Margolis on this amazing achievement! @karapedsgastrodoc.bsky.social

MargolisLab@margolislabnyu.bsky.social · 2w ago

🎉 Beyond proud to celebrate Dr. Margolis in receiving the ANMS Distinguished Investigator Award for Women in Neurogastroenterology! 🏆 A well-deserved honor celebrating her groundbreaking research and incredible mentorship! 💙 @karapedsgastrodoc.bsky.social @nyupainresearch.bsky.social

Not all pain is created equal: stepping on a nail feels different from a stomachache. We know there are many nociceptor types, but a key question remains: how is mechanical pain encoded across the body by those sensory neurons? Our new work helps answer this. 1/8 www.biorxiv.org/content/10.6...

Hierarchical organization of mechano-nociceptive pathways revealed by activity labeling

Noxious mechanical stimuli give rise to distinct percepts, from sharp cutaneous pain to diffuse visceral discomfort, yet the nociceptor ensembles that underlie these differences remain poorly defined....

biorxiv.org

NEW PRC PREPRINT🚨: The des Georges and Bunnett labs elucidated the structural basis of NGF/TrkA blockade by an analgesic antibody! Congrats on this great paper @harsh3b.bsky.social @elisadamo.bsky.social @adesgeorges.bsky.social! www.biorxiv.org/content/10.6...

Structural basis for direct NGF/TrkA blockade by an analgesic antibody

The NGF/TrkA signaling axis is a central mediator of inflammatory and chronic pain, where injury-induced NGF binds and activates TrkA on nociceptive neurons to drive peripheral sensitization and persi...

biorxiv.org

Great new review article from Ru-Rong Ji, Temugin Berta, and colleagues, on neuron-glia interactions in pain! Microglia, astrocytes, and satellite glial cells actively shape pain by driving neuroinflammation, sensitizing neurons, and remodeling pain circuits. journals.physiology.org/doi/full/10....

NEW PRC PAPER 🚨: The Jensen lab discovered that disrupting synaptic vesicle recycling via AAK1, Dnm1, and Dnm3 targets chronic itch at its source. Amazing work @pazduran.bsky.social @tonelloraquel.bsky.social and the team! www.frontiersin.org/journals/mol...

Frontiers | The contribution of endocytic mediators to itch transmission

IntroductionChronic itch is a major burden, impacting the quality of life for one in four adults, and is closely associated with increased levels of anxiety,...

frontiersin.org

NEW PRC PAPER 🚨: The Jensen lab discovered that the human itch receptor MrGPRX1 traffics to the endosomal network, where it continues to signal and drive TRPV1 sensitization. Congratulations to first author @pazduran.bsky.social and the whole team! www.frontiersin.org/journals/mol...

Frontiers | Endosomal MrGPRX1 signaling sensitizes TRPV1 to enhance itch

G protein-coupled receptors (GPCRs) and TRPV (transient receptor potential vanilloid) channels are crucial for signal transduction in physiological processes...

frontiersin.org

NEW PRC PAPER 🚨: The Bunnett lab identified Neuropilin-1 (NRP1) as a key mediator of NGF signaling driving oral cancer pain. Targeting NRP1 disrupts NGF/TrkA signaling, reduces nociceptor sensitization, and alleviates pain without directly blocking NGF! buff.ly/NmyrTLy

Study identifies a new MOR “superagonist” ~1000× more potent than morphine that strongly favors Gαi over β-arrestin signaling, preserving analgesia while reducing side effects linked to tolerance and addiction. #painresearch buff.ly/0ic9fiE

Fantastic visit from Tor Wager yesterday! We were blown away by his talk on a brain systems-level approach to understanding pain! @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social

Excited to be moderating this @painresforum.bsky.social webinar on all things osteoarthritis & pain on July 10th, registration 👉 painresearchforum.org/register-for... #PainResearch #neuroskyence #immunosky

Amazing work from @tonelloraquel.bsky.social!

Raquel Tonello@tonelloraquel.bsky.social · 2mo ago

📣Excited to share our new preprint! We identify synaptic vesicle endocytosis in nociceptors as a key driver of ongoing pain, and show that LNP‑delivered CRISPR/dCas9 repression of this pathway produces durable analgesia across multiple pain models. www.biorxiv.org/content/10.6...

NEW PRC PAPER 🚨 from Nestor Jimenez-Vargas and the Bunnett Lab reveals how elevated proteases and histamine drive IBS visceral pain, showing that a prolonged intracellular PAR2 receptor signaling loop keeps the H1 receptor active to continuously amplify and maintain pain. gut.bmj.com/content/earl...

The excitement from the symposium carried into our PRC Retreat, where we had productive and inspiring conversations about the future of our center and how we can drive meaningful advances for people living with pain. #painresearch @karapedsgastrodoc.bsky.social @sdavidson.bsky.social

More shots from our PRC Symposium yesterday. We were grateful to host wonderful keynote speakers: Dr. Walter Koroshetz, Dr. Lin Chang, Dr. Jeffrey Hubbell, and Dr. Ru-Rong Ji! @karapedsgastrodoc.bsky.social

Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social

We are thrilled to bring together the NYU pain research community at our symposium tomorrow! Looking forward to a day of exciting science, connection, and collaboration.

Exciting new preprint from the Russo Lab at University of Iowa! Blocking α1‑noradrenergic signaling restores glymphatic flow and reverses migraine‑like allodynia in mice.

New study in Science: Pain has a clock, and the brain circuit behind it could redefine how we treat chronic pain! #painresearch

Hypothalamic clock governs circadian pain

Chronic pain exhibits circadian rhythms in humans, but the mechanisms underlying such rhythmicity remain unclear. Here, we found daily oscillations in the nociceptive thresholds in a mouse model of…

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A newly identified spino-brain-spinal cord loop linking the thalamus, somatosensory cortex, and superior colliculus to descending RVMSC neurons specifically drives chronic mechanical pain, and may offer new cellular targets for intervention. #PainResearch buff.ly/FdiGUU4

Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain - Nature

In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

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New research maps the proteomes of individual sensory neuron subtypes, revealing how protein-level changes drive nociceptor sensitization, opening fresh avenues for #painresearch. @garyrlewin.bsky.social @amapruns.bsky.social

Deep visual proteomics uncovers nociceptor diversity and pain targets - Nature Communications

Sensory neuron subtypes are defined by transcriptomics, but their proteomic identities remain unclear. Here, authors show distinct protein signatures of electrophysiologically defined nociceptors and…

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New study from the Price Lab shows that Hibernate A media keeps human sensory neurons functional for up to 42h, enabling storage and long-distance shipping. A major win for translational #painresearch! @tedpricethepainguy.bsky.social @utdpaincenter.bsky.social buff.ly/zaz7UPl

Check out our latest preprint, this one led by PhD student extraordinaire, Khadijah Mazhar: "Satellite microglia-like cells in human dorsal root ganglia and changes with diabetic neuropathy" www.biorxiv.org/content/10.6...

NaV1.7 mRNA and Protein Expression in Resident Neurons of the Human Spinal Dorsal Horn: onlinelibrary.wiley.com/doi/10.1002/... @stephanie-shiers.bsky.social great work on Nav1.7 in human spinal cord is finally published in JCN!

NEW PRC PAPER🚨: The Jing Wang Lab identified a PFC–ACC circuit that gates pain by suppressing ACC activity and reducing pain aversion. #PainResearch

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New research provides the first direct evidence that cAMP binding to HCN2 channels drives nociceptor hyperexcitability. Using the peptide TRIP8bnano to block this interaction successfully reversed pain hypersensitivity in vivo. #PainResearch #Neuroscience #IonChannels buff.ly/3JJuo7t

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New insight into opioid-induced itch! Study identifies a peripheral mechanism: OPRM1 and MRGPRX1 pair up in sensory neurons, switching signaling to drive scratching. Targeting this complex could stop itch without affecting pain relief. #painresearch buff.ly/HIgi6dz

Very proud to share this @usasp.bsky.social podcast episode featuring PRC postdoc Elisa Damo @elisadamo.bsky.social, one of the Top 5 Travel Awardees from the USASP Annual Scientific Meeting! @karapedsgastrodoc.bsky.social soundcloud.com/usasp/episod...

34. 2026 USASP Annual Meeting Top 5 Trainee Travel Awardees

Listen to the top five travel awardees from the 2026 USASP Annual Meeting which took place from March 23-26, 2026 in Philadelphia, Pennsylvania. In this episode, we will learn on the current work fro

soundcloud.com

New work from the Moutal Lab @aubinmoutal.bsky.social shows FGFR3 autoantibodies aren't just markers - they drive small fiber neuropathy pain by directly sensitizing DRG neurons. #Neuropathy #Autoimmune #PainResearch

NEW PRC PAPER 🚨: Research from the @adesgeorges.bsky.social Lab with @harsh3b.bsky.social reveals that beta-arrestin 1 actively drives cell signaling, not just as a scaffold, but as a direct activator. #StructuralBiology #GPCRs buff.ly/4BfXcYz @karapedsgastrodoc.bsky.social