Looking forward to Tak Mak presenting his science in Mannheim. www.umm.de/v-medizinisc...
Immunology Talk with Prof. Dr. Tak Wah Mak
Informationen der Universitätsmedizin Mannheim
umm.de
Andreas Linkermann
@linkermannlab.bsky.social
Chair 5th Med Dept UMM, Heidelberg University Kidney Transplantation and Cell Death Biology
Tissues that undergo ferroptosis exhibit a particularly interesting feature - cell death propagation! This is our first review published today in Nature Cell Biology. Here is a free link: rdcu.be/fBfEx
rdcu.be
Thrilled to have contributed to this work led by @jgcastillo.bsky.social during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. www.science.org/doi/10.1126/...
Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity
Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice.
science.org
Reviewing the paper by the Kats´ lab published today in #Cell, "Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia", I learned that cuproptosis is real! Here is my preview: When heme is low, copper kills cancer: www.cell.com/cell/fulltex...
When heme is low, copper kills cancer
Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respirat...
cell.com
Here is a link to our most recent editorial for #CDDiff, Cell Death and Differentiation. It´s on work by Tony Letai and team. www.nature.com/articles/s41...
What does not kill you makes you Weaker! - Cell Death & Differentiation
Tumor cell evasion from regulated cell death is a hallmark of cancer [1]. Davern et al. now identify resistance to mitochondrial apoptosis to represent the common mechanism by which persister cells th...
nature.com
Nature research paper: Erythropoietin receptor on cDC1s dictates immune tolerance go.nature.com/496nEob
Erythropoietin receptor on cDC1s dictates immune tolerance - Nature
The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.
go.nature.com
Obituary: David Baltimore (1938-2025) virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS go.nature.com/443Vojo
David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.
go.nature.com
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E - Gavali - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E
Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...
advanced.onlinelibrary.wiley.com
Very pleased to share this "spotlight" in Trends in Endocrinology and Metabolism which refers to our recent work. www.sciencedirect.com/science/arti...
Hydroxyestradiol alleviates acute kidney injury via blockade of ferroptosis
The molecular mechanisms underlying sex differences in acute kidney injury (AKI) remain incompletely understood. In a study recently published in Natu…
sciencedirect.com
Here is a "highlight" on our recent work written by Boyi Gan for Cell Death and Differentiation: www.nature.com/articles/s41...
Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury - Cell Death & Differentiation
Cell Death & Differentiation - Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury
nature.com
This refers to our recent manuscript. Estrogen-powered kidney protection | Science Signaling www.science.org/doi/10.1126/...
Estrogen-powered kidney protection
Estrogen protects against kidney injury through both genomic and nongenomic mechanisms.
science.org
STING drives #necroptosis, and here’s how it does it! Congratulations to @gianmaria-liccardi.bsky.social and his amazing team! www.nature.com/articles/s41...
STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature
Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
nature.com
Happy to start at Bluesky with a post on our recent manuscript at @nature.com: www.nature.com/articles/s41... Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
nature.com
Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV
Prospects for ferroptosis therapies in cancer
Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...
rdcu.be
Harvard Molecular Metabolism@met-hsph.bsky.social · last yr.Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out rdcu.be/eBbqV