California Bill Would Create A $23 Billion Fund For University Research

California Bill Would Create A $23 Billion Fund For University Research

A California bill would give voters the chance to vote on whether the state should create a $23 billion bond that would be used to award grants to university researchers.

forbes.com

Happy to share the final version of the study where we describe a central role for vitaminB2 in regulating membrane redox state - some new cool experiments were added since the preprint was posted - pls check this out thttps://www.nature.com/articles/s41556-025-01856-x

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance - Nature Cell Biology

After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

nature.com

#Vitamin B2 is converted into molecules which protect cells from oxidative damage. The downside: It also protects #cancer cells. Scientists at the Rudolf Virchow Centre at #JMU discovered that. 📸 Natalie Fahmer ➡️ www.uni-wuerzburg.de/en/news-and-...

1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis. www.nature.com/articles/s41...

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis - Nature Structural & Molecular Biology

Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

nature.com

New online: FAD-dependent stabilization of FSP1 promotes ferroptosis resistance

FAD-dependent stabilization of FSP1 promotes ferroptosis resistance

Nature Structural & Molecular Biology, Published online: 13 March 2026; doi:10.1038/s41594-026-01760-4The oxidoreductase FSP1 recycles radical-trapping antioxidants that suppress oxidative lipid damage and ferroptosis. A series of genetic screens reveal a key role for the vitamin B2 metabolite flavin adenine dinucleotide in stabilizing FSP1, preventing its proteasomal degradation and promoting ferroptosis suppression.

dlvr.it

Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org

James Olzmann@olzmannlab.bsky.social · 5mo ago

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Cool paper alert 🚨! Congrats @olzmannlab.bsky.social! Proud to have made a small contribution to this. One of the prettiest membrane-protein structures I have simulated ☺️

James Olzmann@olzmannlab.bsky.social · 5mo ago

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

nature.com

A little late on here but happy to share my 3rd first author paper from grad school finally out in Science Advances!! In collaboration with James Olzmann's group, we find that Tregs utilize FSP1/Aifm2 for preventing lipid peroxide accumulation and preserve their suppressive function in tumor models.

James Olzmann@olzmannlab.bsky.social · 6mo ago

Thrilled to have contributed to this work led by @jgcastillo.bsky.social during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. www.science.org/doi/10.1126/...

Thrilled to have contributed to this work led by @jgcastillo.bsky.social during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. www.science.org/doi/10.1126/...

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity

Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice.

science.org

Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪

15. And second, also from @olzmannlab.bsky.social, an ER chloride channel pushes LD formation toward the cytosol vs. nucleoplasm and affects nuclear pore complex assembly in @biorxiv-cellbio.bsky.social www.biorxiv.org/content/10.1...

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly

Imbalances in lipid storage and secretion lead to the accumulation of hepatocyte lipid droplets (LDs) (i.e., hepatic steatosis). Our understanding of the mechanisms that govern the channeling of hepat...

biorxiv.org

14. Two studies that reshape thinking about lipid droplets biology. First, lipid peroxidation can occur to neutral lipids inside the core of LDs, with protective mechanisms revealed, from @mikelangelipid.bsky.social and @olzmannlab.bsky.social in @natcellbio.nature.com www.nature.com/articles/s41...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology

A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...

nature.com

Two weeks left to apply! If you study any area of metabolism or metabolic disease (broadly defined), we encourage you to apply. The dept is excited about biological and molecular mechanisms, metabolic flux, therapeutics, and physiology related to disease. aprecruit.berkeley.edu/JPF04710

Assistant Professor - Environmental Impact on Human Metabolic Disease - Nutritional Sciences and Toxicology

University of California, Berkeley is hiring. Apply now!

aprecruit.berkeley.edu

Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳 www.nature.com/articles/s41...

In vivo models bring FSP1 inhibitors to life - Nature Cell Biology

FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...

nature.com

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson! www.biorxiv.org/content/10.1...

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation

Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

biorxiv.org

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004

The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

nature.com

#NatMetabPicks | In @natcellbio.nature.com led by @olzmannlab.bsky.social ( @ucberkeleyofficial.bsky.social ) FSP1, localized to lipid droplets, protects stored lipids from oxidative damage and prevents ferroptosis. www.nature.com/articles/s41...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

Curious how proteins find their way to #LipidDroplets? Our bipartite review traces their journey from ER insertion to LD partitioning: 👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning #Organelles #EndoplasmicReticulum #ER_Literature

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology

Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

nature.com

Great Endoplasmic Reticulum meeting in Paris organized by the amazing Eric Chevet @ericchevet.bsky.social! It was wonderful to also hang out with James Olzmann @olzmannlab.bsky.social and Rachid Thiam @abdourachidthiam.bsky.social.

A giant in molecular biology and virology has passed. RIP David Baltimore. www.nytimes.com/2025/09/07/s...

David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87

nytimes.com

Join us in celebrating the #ASBMB26 Award Winners! • @abu-remaileh.bsky.social • Suzanne Barbour • @bradylabupenn.bsky.social • George Carman • Joseph Cotruvo • Roger Davis • @rolanddunbrack.bsky.social • Pamela Mertz • @olzmannlab.bsky.social • Kim Orth • Margaret Phillips ow.ly/x05f50WSbax

ASBMB names 2026 award winners

Check out their lectures at the annual meeting in March in the Washington, D.C., metro area.

ow.ly

American Society for Biochemistry and Molecular Biology@asbmb.bsky.social · 11mo ago

Congratulations to the 2026 ASBMB Award Winners! Through their pioneering work, these scientists are advancing discovery, driving innovation, and shaping the future of molecular life sciences. Read more about their work: ow.ly/x05f50WSbax. #ASBMB26 #MakeItPossible

Congrats to MCB's James Olzmann @olzmannlab.bsky.social on receiving the ASBMB 2026 Avanti Award in Lipids @asbmb.bsky.social! 👍🎉

James Olzmann@olzmannlab.bsky.social · 11mo ago

Humbled and honored to receive the 2026 Avanti Award in Lipids from ASBMB! Grateful to my exceptional lab, mentors, and collaborators for their support and inspiration. Excited to keep pushing the boundaries of lipid biology and therapeutics! www.asbmb.org/asbmb-today/...

Humbled and honored to receive the 2026 Avanti Award in Lipids from ASBMB! Grateful to my exceptional lab, mentors, and collaborators for their support and inspiration. Excited to keep pushing the boundaries of lipid biology and therapeutics! www.asbmb.org/asbmb-today/...

ASBMB names 2026 award winners

Check out their lectures at the annual meeting in March in the Washington, D.C., metro area.

asbmb.org

First day of class @UCBerkeley! Kicked off the day peeking in on the Therapeutic Discovery and Development class taught by @dannomura.bsky.social @robzonculab.bsky.social @urnov.bsky.social!! 🤩🔥!!

First day of class @UCBerkeley! Kicked off the day peeking in on the Therapeutic Discovery and Development class taught by @dannomura.bsky.social @robzonculab.bsky.social @urnov.bsky.social!! 🤩🔥!!