Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity

Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice.

science.org

When heme is low, copper kills cancer

Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respirat...

cell.com

What does not kill you makes you Weaker! - Cell Death & Differentiation

Tumor cell evasion from regulated cell death is a hallmark of cancer [1]. Davern et al. now identify resistance to mitochondrial apoptosis to represent the common mechanism by which persister cells th...

nature.com

Erythropoietin receptor on cDC1s dictates immune tolerance - Nature

The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

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David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS

The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

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Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E

Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...

advanced.onlinelibrary.wiley.com

Host cell Z-RNAs activate ZBP1 during virus infections - Nature

Nature - Host cell Z-RNAs activate ZBP1 during virus infections

nature.com

Hydroxyestradiol alleviates acute kidney injury via blockade of ferroptosis

The molecular mechanisms underlying sex differences in acute kidney injury (AKI) remain incompletely understood. In a study recently published in Natu…

sciencedirect.com

Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury - Cell Death & Differentiation

Cell Death & Differentiation - Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury

nature.com

Warum Frauen seltener ein akutes Nierenversagen erleiden – Deutsches Ärzteblatt

aerzteblatt.de

Estrogen-powered kidney protection

Estrogen protects against kidney injury through both genomic and nongenomic mechanisms.

science.org

STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature

Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD

nature.com

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

nature.com

Prospects for ferroptosis therapies in cancer

Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...

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