MichaelMcMurray lab

@mcmurraylab.bsky.social

Official account of Michael McMurray’s lab in the Dept. Cell and Developmental Biology at the University of Colorado Anschutz Medical Campus. We study septin proteins, folding/assembly of multi subunit protein complexes, & various aspects of yeast biology

A reminder to budding yeast researchers: if you use the "GAPDH" promoter to drive constitutive expression, please be careful about how you describe this. The gene GPD1 encodes glycerol-3-phosphate dehydrogenase, not Glyceraldehyde-3-phosphate dehydrogenase. The TDH3 promoter is probably what you use

One of my favorite parts of this paper full of beautiful experiments is the finding that phosphorylation of a regulatory helix switches the direction of transport. Imagine trying to figure this out using only in vitro reconstitution and recombinant proteins! No chance www.science.org/doi/10.1126/...

A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo

The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanis...

science.org

This article includes an abstract in Brazilian Portuguese. It is our first article with an additional language abstract. For more details about this option: journals.biologists.com/jcs/pages/jo...

Journal of Cell Science@jcellsci.bsky.social · 2w ago

Igor Bonacossa-Pereira, Dat Le, Sean Coakley @seancoakley.bsky.social and Massimo Hilliard discover that AGEF-1 modulates cross-tissue mechano-resilience of sensory axons. #OpenAccess #ReadandPublish Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

Figure showing that AGEF-1 interacts with RAB-35 in vivo within the epidermis.

Officially recruiting postdocs at GW. If you are interested in genetic novelty, structural variation, or evo genetics please get in touch! We have data sets on mulitple organisms with large population sizes (Drosophila, Megalonaias nervosa) and species in decline (fireflies, mussels, elephants).

Join us in a fun, crazy and interesting interdisciplinary research project that combines protein biophysics, evolutionary genomics, biomolecular archaeology, and textile research to resolve species identity and post-translational modifications in the structural proteins collagen and keratin

Matthew Collins@matthewcollins.bsky.social · last mo.

Copenhagen job alert 🚨 GLOBE (@ucph.bsky.social) is hiring a 21-mo Postdoc in #Bioinformatics & #ComputationalProteomics Work with @lindorfflarsen.bsky.social, @fridowelker.bsky.social, @brandtgroup.bsky.social & more mapping collagen/keratin diversity across 1000s of genomes. 📅 Deadline Aug 31

1/ Mitochondrial Na⁺ links metabolism, Ca2+ signaling and disease. We know how it gets in, how it gets out, and proteins that use it. But: we've never actually seen Na⁺ in single mitochondria in live cells. We started with an unusual observation, went down a rabbit hole & found some cool biology .

A mitochondrion showing Ca2+ entering through the MCU, exchanged for Na+ by NCLX, Complex I acting as a Na+/H+ exchanger, and various transporters that use Na+ to move their substrates in and out of the mitochondria