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Sarah Nicolas

@sarah-nicolas.bsky.social

Marie Skłodowska-Curie Postdoctoral Fellow at CRCA-CBI #Microglia #Exercise #microbiota #GutBrainAxis #Alzheimer

21 Posts742 Follower748 Folgt
Fabien Naneix@fabnaneix.bsky.social · 3mo ago

New review on Dopamine ensembles regulating appetite, feeding, and energy homeostasis now available in Trends in Endocrinology & Metabolism. Thank you @peppeganga.bsky.social for the invite, and to Oriane Onimus and @katepeters3.bsky.social for their fantastic work www.cell.com/trends/endoc...

Dopamine ensembles regulating appetite, feeding, and energy homeostasis

Beyond its classical role in gating reward processes, dopamine (DA) also contributes to the orchestration of feeding and energy balance. This review synthesizes and discusses recent advances in unders...

cell.com

Roli Roberts@roliroberts.bsky.social · 4mo ago

This is such a cool study, arising from a chance observation in the field. The authors were filming the flashing of fireflies in Thailand, but noticed that the chirping of nearby crickets seemed to be synced to the flashes...

Quote: "In the summer of 2022, members of our research group went on a field excursion to Thailand to film the Pteropyx malaccae firefly, famous for its synchronous displays. While filming, we noticed that nearby crickets (most likely of the Podoscirtinae subfamily—unfortunately, we failed to catch any specimen to confirm the exact species) often seemed to chirp in synchrony with the fireflies. Luckily, our microphones were on. Were the rhythmic communications at near-identical tempos (see Fig 1A, B) a case of interspecies, intermodal synchrony? Detailed analysis showed that the crickets and fireflies were not actually synchronized. But their signaling tempos, both close to 2.4 Hz, differed by only about 10%."
PLOS Biology@plosbiology.org · 4mo ago

Do animals have a favored tempo for communicating with each other? This study reveals a hotspot of 0.5-4 Hz for #communication across distinct species & modalities, hypothesizing that this may driven by biophysical commonalities of the receivers' #neurons @plosbiology.org 🧪 plos.io/4ccWuhh

Tempo comparison across scales, taxa, modalities, and media. Top left: Spectrogram of cricket(s) chirping for 1 min. Top right: Spectrogram of nearby fireflies flashing for 1 min (N = 21). The colorbars in both heatmaps correspond to Power/frequency (dB/Hz). Bottom: Typical tempos at which different animals signal vs. their respective mean body weights on a logarithmic scale (N = 24). The plot consists of six main groups: insects, amphibians, birds, fish, crustaceans (these last four in an overlapping region due to similar weights—note that the labels here don’t necessarily correspond to specific points as the species are mixed), and mammals. The icons (light bulb, speaker, and a moving human) represent the form of the signal (light, sound, or gesture). Note that the signals are mostly transmitted through air, with two examples through water (both fish, written in blue).
Sarah Nicolas@sarah-nicolas.bsky.social · 4mo ago

Happy to see this work, led by our amazing Dr Caruso now out in Neuropharmacology !

APC Microbiome Ireland@apcmicrobiomeirel.bsky.social · 4mo ago

#Exercise type can shape brain-related outcomes differently. A new paper in 𝑵𝒆𝒖𝒓𝒐𝒑𝒉𝒂𝒓𝒎𝒂𝒄𝒐𝒍𝒐𝒈𝒚 found that after 8 weeks, treadmill exercise improved spatial memory, while wheel running increased adult hippocampal #neurogenesis in rats. 📰 buff.ly/YS5tNUI #brainhealth @oliviafoleary.bsky.social

Differential effects of wheel running and treadmill exercise on spatial memory, adult hippocampal neurogenesis and the cerebrospinal fluid proteome in rats
Nature Portfolio@natureportfolio.nature.com · 4mo ago

Ancient DNA from grape seeds spanning 4,000 years reveals the domestication, cultivation, and trade of grapes in France over this period, according to research in Nature Communications. The authors find that one Medieval sample is genetically identical to modern Pinot Noir grapes. 🧬 🏺 🧪

Ancient DNA reveals 4000 years of grapevine diversity, viticulture and clonal propagation in France - Nature Communications

Here, the authors present aDNA from 49 grape pips spanning the Bronze Age to Medieval period in France and surrounding areas. They find evidence of long-distance exchange of domestic varieties through vegetative clones and one Medieval sample that is nearly identical to modern Pinot Noir.

go.nature.com

Andrew Octavian Sasmita@aosasmita.bsky.social · 7mo ago

Where does Aβ come from in Alzheimer’s disease? 🔍 In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting. link.springer.com/article/10.1...

A Question of Origins: Non-neuronal Sources of Amyloid-β - Neuroscience Bulletin

Amyloid-β (Aβ) plaques and neurofibrillary tau tangles are hallmarks of Alzheimer’s disease (AD). While the intracellular localization of tau tangles within neurons nominates them as the primary produ...

link.springer.com

Sarah Nicolas@sarah-nicolas.bsky.social · 11mo ago

Happy to see published the last piece of a fruitful (and fun!) collaboration on Adiporon… from depression to osteoporosis. www.sciencedirect.com/science/arti...

The adiponectin agonist AdipoRon accelerates osteoporosis development in two different models and modulates adipocyte differentiation

Osteoporosis is an increasing concern in the aging population worldwide, culminating in increased economic concerns and diminished quality of life. Si…

sciencedirect.com