Çagla Tükel
@caglatukel.bsky.social
Professor of Microbiology, immunology and inflammation. Interested in host-biofilm interactions, bacterial amyloid curli and microbial pathogenesis
Bacterial biofilms provoke antibodies against the less common left-handed DNA helix (Z DNA) which are often found in autoimmune conditions 📷 Molly Elkins et al @caglatukel.bsky.social lab @katztemplemed.bsky.social in @plos.org Pathogens ➡️ bpod.org.uk/archive/2026/8/25 with @antdlewis.bsky.social
🎉 Congratulations to Dr. Molly Elkins, on successfully defending her PhD dissertation! It has been a privilege to mentor Molly throughout the PhD phase of her training. Wishing her continued success as she returns to medical school to complete the final stage of her MD/PhD journey.
Is colorectal cancer driven by a disruption of anaerobiosis? A recent study by Spiga et al. makes this idea walk and talk like a duck. Read more here: www.sciencedirect.com/science/arti...
An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut
To colonize their host and cause disease, enteric pathogens must deploy their virulence factors to establish distinct nutrient niches. How anaerobic p…
sciencedirect.com
Honored to be elected as a Fellow of the American Academy of Microbiology (Class of 2026). Grateful to be part of this distinguished group of scientists.
Congratulations to Çagla Tükel @caglatukel.bsky.social for her election to fellowship in the American Academy of Microbiology! asm.social/2OC
63 Fellows Elected to the American Academy of Microbiology
The American Academy of Microbiology elected 63 new fellows to the Class of 2026.
asm.social
Two weeks two PhD defenses from Tukel lab. Congratulations to Drs Kaitlyn Grando and Shingo Bessho. So proud with both of their accomplishments @kaiterwaul.bsky.social @besshoshingo.bsky.social
Listened to some great talks, delivered a talk, received good feedback and spent good time with friends #ASMMicrobe. Time to say goodbye to LA
Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b... Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......
CHECK IT OUT 🦠👀 Very cool article by science journalist Carrie Arnold reviewing recent research from leading laboratories on how the unique shape of a microbial #biofilm emerges from interactions of its component microbes with each other and their environment www.quantamagazine.org/how-a-biofil...
Proud of my student Kaitlyn Grando @kaiterwaul.bsky.social Her work and accomplishments were featured in Katz news #Temple. medicine.temple.edu/news/2025/02...
Kaitlyn Grando’s Groundbreaking Work in Biofilm Research
medicine.temple.edu
Beautiful review by @abaumler discussing the factors that contribute to gut microbiota assembly
Andreas Bäumler@abaumler.bsky.social · last yr.🔬🦠 How to make sense of the taxonomic complexity & interpersonal variability of the gut microbiota? We propose that beneath this complexity lies a hierarchy of factors that control gut microbiota assembly. Read more! #Microbiome #GutHealth authors.elsevier.com/a/1km32_,2Ci...
Very happy to be a part of this beautiful study led by Drs Maria Cimini and Raj Kishore showing a role for SAA3 amyloidosis after myocardial infarction (MI) and how SAA3 loaded exosomes can drive injury www.sciencedirect.com/science/arti...
Podoplanin-positive cell-derived small extracellular vesicles contribute to cardiac amyloidosis after myocardial infarction
Cardiac amyloidosis is a secondary phenomenon of an already pre-existing chronic condition. Whether cardiac amyloidosis represents one of the complica…
sciencedirect.com
Local traditional media still works! We shot this interview on the grounds of the former J&L steel mill, where buildings including my lab are today. The threat to biomedical research in Pittsburgh is on par with the threat to the mills 50 years ago. www.wtae.com/article/pitt...
Pittsburgh researcher warns NIH cuts could harm patient care, economic growth
Pittsburgh's economy once relied heavily on the steel industry, which lined Second Avenue with miles of mills. When that industry collapsed, medicine and education filled the economic void.
wtae.com
Studies show that funding from the National Institutes of Health (NIH) contributed to 354 of 356 drugs (99.4%) approved by the FDA from 2010 to 2019. Recklessly slashing NIH funding will mean that patients will be waiting much longer for life-saving treatments.
Important editorial: the "existential moment requiring careful and consistent action to preserve the values and ambitions of science." "The weeks ahead may be the greatest test that the US scientific community has ever faced" By @holdenthorp.bsky.social @science.org www.science.org/doi/full/10....
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
NIH funding freeze stalls applications on $1.5 billion in medical research funds
The National Institutes of Health had to stop considering new grant applications, delaying funding for research into diseases ranging from heart disease and cancer to Alzheimer's and allergies.
npr.org
On March 7th we will Stand Up For Science! You can use the link to find the protest location in your city. standupforscience2025.org
Amyloid-β precursor protein promotes tumor growth by establishing an immune-exclusive tumor microenvironment https://www.biorxiv.org/content/10.1101/2025.02.10.637339v1
A Direct Hit, by @holdenthorp.bsky.social @science.org www.science.org/doi/full/10.... "This is a moment to unite."
Threats to the NIH and our research infrastructure hit me twice- once as a scientist, and again as a patient whose next option will be a clinical trial. Remember that there are real people’s lives at stake.
a phone case that says " do n't forget me " next to a phone
ALT: a phone case that says " do n't forget me " next to a phone
media.tenor.com
Today is International Day of Women & Girls in Science. Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM
My graduate student @besshoshingo.bsky.social gave an oral presentation on the role of Type I IFNs and Salmonella mediated autoimmunity at #MAMPM. Thank you organizers for a wonderful meeting in beautiful VA @lawrenzlab.bsky.social @davislabjhu.bsky.social
Congratulations to my student Kaitlyn Grando @kaiterwaul.bsky.social for being awarded Dr. Mark Shirtliff award for excellence in biofilm research. Thank you MAMPM.org #MAMPM
From the S. Shin lab sunnyshinlab.bsky.social: Hu guanylate-binding protein 1 (GBP1) damages the vesicle around Legionella, revealing the pathogen to the cell by activating inflammasomes. In contrast, murine GBPs can directly attack cytosolic Legionella. doi.org/10.1128/mbio... #mbio #ASM #MicroSky
Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation | mBio
Inflammasomes are essential for host defense against intracellular bacterial pathogens like Legionella, as they activate caspases, which promote cytokine release and cell death to control infection. I...
doi.org
