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Gabriel Santpere

@santperelab.bsky.social

13 Posts49 Follower70 Folgt
Cedric Boeckx@cedricboeckx.bsky.social · 4mo ago

Awesome gift to the research community: a compendium of transcriptomic data for the exploration of neocortical development—gene-level transcriptomic data from ~200(!!!) studies of neocortical development & in vitro models Thanks @carlocolantuoni.bsky.social & colleagues 🙏 @natneuro.nature.com 🧪🧠

NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development - Nature Neuroscience

NeMO Analytics is a compendium of public transcriptomic data focused on the neocortex, enabling biologists without coding expertise to explore hundreds of datasets. Joint decomposition of these data y...

nature.com

Gabriel Santpere@santperelab.bsky.social · 5mo ago

New co-first author paper on how ZBTB18 shapes excitatory neuron diversity in mammals. Led by Nenad Sestan with an amazing team. Thanks to Xabier de Martin for key work on the regulatory network. @researchmar.bsky.social @grib-barcelona.bsky.social @yaleschoolofmed.bsky.social surl.li/rgawzx

Adaptive evolution of gene regulatory networks in mammalian neocortex - Nature

The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which di...

nature.com

Gabriel Santpere@santperelab.bsky.social · 5mo ago

Check out this new study, led by Suel-Kee Kim, Adriana Cherskov, and Nenad Sestan, on human-specific cerebellar biology and the unexpected role of ZP2. Glad to have contributed with excellent work from Xoel Mato and Jose Manuel Ruiz. @researchmar.bsky.social www.cell.com/cell/fulltex...

Human-specific features of the cerebellum and ZP2-regulated synapse development

Human-specific transcriptomic and regulatory features are present in the cerebellum, with ZP2 playing a key role in synapse regulation. ZP2 expression is induced by pontine mossy fibers, leading to de...

cell.com

Suel-Kee Kim@suelkeekim.bsky.social · 11mo ago

Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...

Human-specific features of the cerebellum and ZP2-regulated synapse development

Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...

biorxiv.org

Gabriel Santpere@santperelab.bsky.social · last yr.

Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey! @researchmar.bsky.social rdcu.be/evCaU

Early developmental origins of cortical disorders modeled in human neural stem cells

Nature Communications - The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem...

rdcu.be

Navjot Kaur@babyamygdala.bsky.social · last yr.

Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1

Parc de Recerca Biomèdica de Barcelona@prbb.org · last yr.

🦠Although infection by the #EpsteinBarrVirus is necessary to develop #MultipleSclerosis, only 0.3% of those infected develop it. A new European project with the participation of 3 PRBB centres aims to understand why and the underlying mechanism. More 👇 ellipse.prbb.org/ebv-ms-unvei...

EBV-MS: Unveiling the relationship between Epstein-Barr virus and multiple sclerosis - El·lipse

A 5-year Horizon Europe-funded project aims to uncover the role of the EBV virus in the onset and progression of the Multiple Sclerosis (MS) disease .

ellipse.prbb.org

Gabriel Santpere@santperelab.bsky.social · last yr.

Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now! @grib-barcelona.bsky.social @researchmar.bsky.social @cp-trendsgenetics.bsky.social www.sciencedirect.com/science/arti...

The impact of human accelerated regions on neuronal development

Human accelerated regions (HARs) are the fastest-evolving sequences in the human genome since the divergence from chimpanzees. Some of these regions a…

sciencedirect.com

Cedric Boeckx@cedricboeckx.bsky.social · 2y ago

Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com www.nature.com/articles/s41...

Specification of claustro-amygdalar and palaeocortical neurons and circuits - Nature

A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.

nature.com

Prof Sam Illingworth@samillingworth.com · 2y ago

🧬 Human Brain Evolution New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour. 🔗 www.pnas.org/doi/10.1073/... #Neuroscience #Evolution #SciComm 🧪

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org