Navjot Kaur
@babyamygdala.bsky.social
Associate Research Scientist in Nenad Sestan Lab at Yale University. Interested in Amygdala, Claustrum and Insula Development and their connectivity. Love Tracing and Tracking Neurons. Views are my own.
Adaptive evolution of gene regulatory networks in mammalian neocortex www.nature.com/articles/s41... - very interesting work from Nenad Sestan and colleagues...
Adaptive evolution of gene regulatory networks in mammalian neocortex - Nature
The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which di...
nature.com
Happy to share my co-first-author paper, now published in Nature! In this work, we uncover gene regulatory networks that underlie the diversification and connectivity of excitatory neurons in the neocortex. www.nature.com/articles/s41...
Adaptive evolution of gene regulatory networks in mammalian neocortex - Nature
The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which di...
nature.com
1/ Our new study, led by Jingwen Ding, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification www.nature.com/articles/s41...
Dissecting gene regulatory networks governing human cortical cell fate - Nature
Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissecti...
nature.com
Still think brain regions don’t exist? That everything is everywhere? That cell types don’t matter and that everything is a dynamical phase portrait? Wrong. Interconnected brain modules exist at the level of fine grained transcriptomics. www.nature.com/articles/s41...
Whole-cortex in situ sequencing reveals input-dependent area identity - Nature
BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.
nature.com
🧠✨ Genetic Tools Atlas 3.0 is here! The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets. 🔗 https://portal.brain-map.org/genetic-tools/genetic-tools-atlas #neuroskyence
We often think of problems as separate buckets: disease, malnutrition, affordability or economic development. But “Climate change is not a separate bucket,” Hayhoe says. “The reason we care about climate change is that it’s the hole in every bucket.”
Psychedelics disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/psychedelics...
Psychedelics muddy fMRI results: Q&A with Adam Bauer and Jonah Padawer-Curry
The drugs disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help…
thetransmitter.org
Pharmaceutical industry money can’t replace NIH funding | STAT share.google/iZfAlSgXeIR3... #BasicScience #NIH #NSF #NASA #JOBS #RESEARCHFUNDING #RESEARCHMATTERS #InnovationNation #AmericaFirst
Corporate support cannot make up for threats to the NIH budget
The privatization of medical research can’t replace what the NIH has provided.
share.google
How Jane Goodall changed the way we see animals - and the world by @rowhoop.bsky.social for @newscientist.com www.newscientist.com/article/2498...
How Jane Goodall changed the way we see animals - and the world
Jane Goodall, who chronicled the social lives of chimps, has died, but has left a lasting legacy on how we view the natural world
newscientist.com
A spatially resolved transcriptomic atlas of the primate amygdala (human, macaque, and baboon) now out in Science Advances (www.science.org/doi/10.1126/...). The amygdala contains 32 types of neurons with many neuron types specific to particular subdivisions. Lots of updates from the preprint!
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates
Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.
science.org
Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates
Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.
science.org
Asked about his decision to fire the entire vaccine advisory committee of the CDC, RFK Jr. asserted that "children get between 69 and 92 vaccines before they’re 18," among other lies. Fact check: the number is closer to between 24 and 50. https://trib.al/uUQLOgI
After Purging Key Vaccine Panel, RFK Jr. Moves to Assert Control
The HHS chief went on Fox News to repeatedly lie about vaccines and the members of an advisory committee he recently purged.
trib.al
Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...
My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
Day 25 (a need): Psychiatric conditions are diagnosed based on symptoms rather than biological tests like brain scans or blood tests. We do not yet know enough about what's happening in the brain of someone experiencing a depressive episode or psychosis to create such a test. #ElusiveCures30
Nicole Rust@nicolecrust.bsky.social · last yr.30 days to the launch of Elusive Cures! I learned so much writing it, and I want to share it. For the next 30 days, I'll post brain & mind research breakthroughs on odd days, and highlight unmet needs on even ones. #ElusiveCures30 First breakthrough: /1 press.princeton.edu/books/hardco...
Einstein: Scientists should not be silent about human affairs. Science shouldn’t be partisan, but scientists should embrace values that improve humanity. Science affects people and the people — humanity — affect science.
Ryan Marino, MD@ryanmarino.bsky.social · 2y ago"I do not share your view that the Scientist should observe silence in political matters, i.e. human affairs in the broadest sense. The situation shows whither this restraint will lead: to the surrender of leadership, without any resistance, to those who are blind or irresponsible.” -Einstein, 1933
Podcast interview with me about spatial planning in London taxi drivers: youtube.com/watch?v=6gUR...
London black cabs beat AI to show 'genius of human mind' ...The Standard podcast
YouTube video by The London Standard
youtube.com
In fiscal year 2024, the report found, NIH awarded more than $36.9 billion to researchers, supporting more than 408,000 jobs and generating over $94.5 billion in new economic activity nationwide. news.harvard.edu/gazette/stor...
NIH funding delivers exponential economic returns — Harvard Gazette
Report finds all 50 states reap gains in patient health, job creation, research resources, business development.
news.harvard.edu
Excited to share this brief review where @katieinsel.bsky.social & I discuss studying adolescence to understand how brains work! We highlight avenues for future collaborative work at the intersection of cognitive, computational, & developmental neuroscience 🧠 journals.sagepub.com/doi/10.1177/...
When you've been in the cell culture hood all day and finally get to take off your gloves:
@michellemonje.bsky.social at @stanfordmedicine.bsky.social and Frank Winkler at Heidelberg University have won the 2025 @brainprize.bsky.social from the Lundbeck Foundation for their work in cancer neuroscience. By @sydneywyatt.bsky.social #neuroskyence www.thetransmitter.org/community/20...
2025 Brain Prize honors pair of cancer neuroscientists
Michelle Monje and Frank Winkler share the $1.4 million award for their discovery of synapses between brain cancer cells and neurons.
thetransmitter.org
I’m excited to share our publication from @dulaclab.bsky.social in @nature.com, where we illuminate the development of hypothalamic cell types involved in a broad range of functions, from social behaviors to thirst, thermoregulation, and sleep. Highlights below! 🧵 www.nature.com/articles/s41...
Sensory input, sex and function shape hypothalamic cell type development - Nature
Paired transcriptomic and chromatin accessibility profiling are used to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, including cell types with ke...
nature.com
It continues to get worse. We can’t breathe a sigh of relief because it isn’t MY grant. We all risk being on the chopping block. Not even to mention the severe detriment to science, society, etc. 😢 www.nature.com/articles/d41...
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
nature.com
New work by @gozziale.bsky.social on the phenotypic heterogeneity in autism spectrum disorder and underlying processes, with two major subtypes—hypo- & hyper-connectivity—linked to synaptic dysfunction transcriptional regulation/chromatin remodeling, respectively 🧪🧠🧬 www.biorxiv.org/content/10.1...
Biological subtyping of autism via cross-species fMRI
It is frequently assumed that the phenotypic heterogeneity in autism spectrum disorder reflects underlying pathobiological variation. However, direct evidence in support of this hypothesis is lacking....
biorxiv.org
Poor old Pavlov. Eventually every time he heard a bell ring he wanted to feed a dog.
I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...
Experts Call NIH Budget Cuts an 'Apocalypse' for Science
The reductions target indirect costs that cover administrative and equipment costs.
time.com
