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Suel-Kee Kim

@suelkeekim.bsky.social

Neuroscientist, Sestan Lab @yaleneuro.bsky.social, Brain Development and Evolution, Human-Specific Features, #Cerebellum, Pluripotent Stem Cells, #iPSC, Individual Variation

3 Posts217 Follower530 Folgt
Navjot Kaur@babyamygdala.bsky.social · 5mo ago

Happy to share my co-first-author paper, now published in Nature! In this work, we uncover gene regulatory networks that underlie the diversification and connectivity of excitatory neurons in the neocortex. www.nature.com/articles/s41...

Adaptive evolution of gene regulatory networks in mammalian neocortex - Nature

The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which di...

nature.com

Cell - a Cell Press journal@cp-cell.bsky.social · 5mo ago

Now online! Human-specific features of the cerebellum and ZP2-regulated synapse development

Human-specific features of the cerebellum and ZP2-regulated synapse development

Human-specific transcriptomic and regulatory features are present in the cerebellum, with ZP2 playing a key role in synapse regulation. ZP2 expression is induced by pontine mossy fibers, leading to decreased synaptic proteins and neuronal activity, which provides insights into the evolutionary development of the human cerebellum.

dlvr.it

Gabriel Santpere@santperelab.bsky.social · 5mo ago

Check out this new study, led by Suel-Kee Kim, Adriana Cherskov, and Nenad Sestan, on human-specific cerebellar biology and the unexpected role of ZP2. Glad to have contributed with excellent work from Xoel Mato and Jose Manuel Ruiz. @researchmar.bsky.social www.cell.com/cell/fulltex...

Human-specific features of the cerebellum and ZP2-regulated synapse development

Human-specific transcriptomic and regulatory features are present in the cerebellum, with ZP2 playing a key role in synapse regulation. ZP2 expression is induced by pontine mossy fibers, leading to de...

cell.com

Mari Sepp@marisepp.bsky.social · 6mo ago

How have concerted and mosaic evolutionary mechanisms shaped the expansion of the human cerebellum? Our review with @tyamadat.bsky.social and @ioansarr.bsky.social available free till March 29: authors.elsevier.com/a/1ma2wFzn7a...

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Mari Sepp@marisepp.bsky.social · 6mo ago

This paper marks the end of a long but rewarding project - and the start of something new (more below👇). Massive thanks to @kaessmannlab.bsky.social, @ioansarr.bsky.social, @tyamadat.bsky.social, our amazing collaborators @steinaerts.bsky.social, Stefan Pfister, Rüdiger Behr and the entire team! 💙

Yale Neuroscience@yaleneuro.bsky.social · 11mo ago

In a new @natcomms.nature.com study, @yaleneuro.bsky.social's Nicola Micali from the Rakic lab, alongside a team of researchers @prbb.org, found that many genes 🧬 linked to mental illness 🧠 are turned ON in neural stem cells as early as the first trimester.👶

Origins of mental illness, fast gas for a black hole

Yale researchers discover a gas guzzling black hole, learn that mental illness may start to develop earlier than once thought, and explore why some brain seizures cause a loss of consciousness.

news.yale.edu

Meera Sundaram@meera-sundaram.bsky.social · last yr.

There is so much cool #aECM work going on but most of the researchers don’t know or talk to each other; this is an attempt to change that! Link below

Pujol lab@pujol-lab.bsky.social · last yr.

... a new virtual seminar series on apical extracellular matrix #aECM on different #organisms 🪱🪰🐁🌱🦠will start in Fall 2025, with short talks and discussions If you are interested 👉https://forms.gle/Y6UjbnXPH1pDHAE97 @meera-sundaram.bsky.social @gotworms.bsky.social @heiman.bsky.social

Suel-Kee Kim@suelkeekim.bsky.social · 11mo ago

Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...

Human-specific features of the cerebellum and ZP2-regulated synapse development

Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...

biorxiv.org

Gabriel Santpere@santperelab.bsky.social · last yr.

Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey! @researchmar.bsky.social rdcu.be/evCaU

Early developmental origins of cortical disorders modeled in human neural stem cells

Nature Communications - The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem...

rdcu.be

Suel-Kee Kim@suelkeekim.bsky.social · last yr.

Excited to share our latest work, Mato-Blanco et al., nature.com/articles/s41.... Thanks to the incredible collaboration with Nicola Micali, Rakic lab, Sestan lab, Vaccarino lab @yaleneuro.bsky.social @santperelab.bsky.social @carlocolantuoni.bsky.social

Early developmental origins of cortical disorders modeled in human neural stem cells - Nature Communications

The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem cells, revealing vulnerabi...

nature.com

Jeremiah Tsyporin@tsyporin.bsky.social · last yr.

Thrilled to present MIND! A model for how the sensorimotor–association axis of the neocortex develops. Huge thanks to the incredible multidisciplinary team who made this happen. www.biorxiv.org/content/10.1...

Competing Programs Shape Cortical Sensorimotor-Association Axis Development

The neocortex is organized along a dominant sensorimotor-to-association (S-A) axis, anchored by modality-specific primary sensorimotor areas at one end and transmodal association areas that form distr...

biorxiv.org

Navjot Kaur@babyamygdala.bsky.social · last yr.

Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1