Antibiotic resistance mutations with fitness costs in rich medium can have no cost, or even a fitness benefit, in synthetic urine. Lovely preprint from @rachelmwheatley.bsky.social's lab, with data linking the growth advantage to the presence of oxaloacetate www.biorxiv.org/content/10.6... #MIcroSky
Fitness costs of antibiotic resistance mutations in rich media do not reliably predict those in infection-like environments
The acquisition of antibiotic resistance is typically associated with a fitness cost, reducing the competitive ability of cells in the absence of antibiotics. Our ability to predict these costs inform...
biorxiv.org
