Closes tonight at 23:59! Last chance to apply for this #job with @gpollara.bsky.social and me! 👇 #UTISky #MicroSky

Prof Jenny Rohn@jennyrohn.bsky.social · 2d ago

Closing soon! Great research role joint with @gpollara.bsky.social and me at @uclmedsci.bsky.social Come for the mystery of how bacteria affect the human bladder during recurrent #UTI - stay for the immunology, 'omics, innovative 3D urothelial modelling & friendly atmosphere! rb.gy/xmw5b5 #UTISky

Please do consider applying for this exciting lab role with @gpollara.bsky.social and me - nice blend of advanced culture models, immunology, microbiology and ‘omics, in our friendly Central London labs. Closes 2 Oct, please amplify! Happy to chat informally #UTI #UTISky

Gabriele Pollara@gpollara.bsky.social · 2w ago

🚨 NEW RESEARCH TECHNICIAN POST 🚨 👉 Interested in understanding the biology of recurrent UTI? 👉 Keen to work in my own and @jennyrohn.bsky.social research groups at UCL? Then please do take a look at new position available 👇. Informal enquiries encouraged. #UTISky www.ucl.ac.uk/work-at-ucl/...

🚨 NEW RESEARCH TECHNICIAN POST 🚨 👉 Interested in understanding the biology of recurrent UTI? 👉 Keen to work in my own and @jennyrohn.bsky.social research groups at UCL? Then please do take a look at new position available 👇. Informal enquiries encouraged. #UTISky www.ucl.ac.uk/work-at-ucl/...

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk

More diagnostic tests don't always = better or reduced antibiotic prescribing. Well, not CRP in primary care anyway! #IDSky #ClinMicro @jac-amr.bsky.social academic.oup.com/jacamr/artic...

Is C-reactive protein the answer to antibiotics over-prescribing in primary care? A behavioural experiment in two European countries

AbstractBackground. Antibiotic overprescribing fuels antimicrobial resistance. C-reactive protein (CRP) is widely promoted as a point-of-care test for targ

academic.oup.com

Less is more, ortho-ID edition Another game changer in ortho ID from the group that brought you OVIVA Pts with ortho infections who underwent curative surgery (no DAIR) with local implantation of abx were randomized to <=7d vs >=4w ABx No Dif in 12 mo relapse www.nejm.org/doi/full/10.... #IDSky

Obligatory "en route" photo to EMBO "the complexity of mycobacterial infections" meeting in Paris. Looking forward to presenting some of our work on leprosy reaction immunopathogenesis. #embocomplexinfections @embo.org #TBSky #leprosy

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n

Antimicrobial use in ECMO is poorly described. We evaluated AU at our center and found, despite no ECMO specific ppx protocol, antimicrobials were prescribed on 85% of pt days😱 doi.org/10.1017/ash.... Also my teams first use of a bubble plot 🫧 #ECMO #IDSky @ashejournal.bsky.social

Antimicrobial use in adult patients receiving extracorporeal membrane oxygenation in a center without routine prophylaxis | Antimicrobial Stewardship &amp; Healthcare Epidemiology | Cambridge Core

Antimicrobial use in adult patients receiving extracorporeal membrane oxygenation in a center without routine prophylaxis - Volume 6 Issue 1

doi.org

Terrible advert on London Underground. How about booking an appointment to speak to a human doctor to discuss medical concerns?

Really happy to finally get this published! This is a qualitative study on front-line clinicians' rationale for sending urine cultures. The 4 themes we identified are summarised in the diagram. #UTIsky www.cambridge.org/core/journal...

Changing the culture: a qualitative study on clinicians’ rationale for requesting urine cultures | Antimicrobial Stewardship &amp; Healthcare Epidemiology | Cambridge Core

Changing the culture: a qualitative study on clinicians’ rationale for requesting urine cultures - Volume 6 Issue 1

cambridge.org

Late to this, but great news!! Have always found manual thread numbering a tricky art to master 4/2 <END>

Bluesky@bsky.app · 4w ago

Thread numbering is out of beta! Threaded posts are now automatically numbered, to help you follow along. Check out the automatic numbering on this thread to see it in action.

Feels a pretty non-controversial title! 😅 (and maybe true for any specialty /profession?!) #AcademicSky #MedSky www.thelancet.com/journals/lan...

High-quality mentorship can improve physician-scientist recruitment, retention, and career satisfaction

Physician-scientists, who engage in both patient care and scientific inquiry, represent an increasingly small portion of the physician workforce. In the USA, only 1·3% of physicians reported research ...

thelancet.com

"Infection-embedded (penicillin allergy) de-labelling is a high-yield intervention that can deliver immediate stewardship returns in patients with active infection needs" #IDSky #ClinMicro @jac-amr.bsky.social academic.oup.com/jacamr/artic...

When I have a spare moment (badaboom! 😅) going to need to read this carefully. On face of it illustrates trade offs at the edge of minimal Abx treatment durations. What worse outcomes is one willing to accept in return for shorter treatment duration? #IDSky #MedSky www.nejm.org/doi/full/10....

Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis | NEJM

In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clin...

nejm.org

Kudos to the title of this paper: From bedside to broadband.... 👏 #IDSky

From bedside to broadband: Evaluating outcomes of telehealth infectious diseases consultations

Following replacement of in-person with telehealth infectious diseases consultation at a community hospital, mortality, readmission, length of stay and tra

academic.oup.com

Excited to share our new paper in Nature Communications! 🎉 Using advanced human bladder models, we explored how the urinary microenvironment and fluid flow shape UPEC pathogenesis and treatment responses. The big message: the environment matters (1/6) 🔗 www.nature.com/articles/s41...

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli - Nature Communications

Maset et al. show that bladder conditions strongly influence how urinary tract infections respond to antibiotics and bacteriophages, highlighting the need for more realistic lab models to improve diag...

nature.com

Over 100 years ago, Lepra was founded on the premise of evidence-led treatment, community care and compassion - breaking down centuries of stigma. On #InternationalDayofCharity, help us continue to reach those who still desperately need us. https://ow.ly/Y7VE50ZFvOo 📷 Tom Bradley Photography

UCL looking good (and busy) for its annual Open Day @ucl.ac.uk

Delighted to have contributed (a little) to this - dissecting role of urine, flow and phages on E. coli-urothelial interaction. Most remarkable to me was ability of phages to kill intracellular bacteria AND alter the host inflammatory response. "How" is the next interesting question... 🤔 #UTISky

Prof Jenny Rohn@jennyrohn.bsky.social · 4w ago

Thrilled our latest paper out @natureportfolio.nature.com Nature Comms, lead author @microberamon.bsky.social, who developed P-FLO, a urine-flowing human micro-bladder model in collab with Oxford & Leicester to understand #UTI biology & treatment failure 1/4 #UTISky www.nature.com/articles/s41...

Amazon really needs to up its game - kids are actually still at school!! Can we not even have a gap before thinking about planning the back to school bit?! 🙏

Disappointing data on meningitis vaccine preventing Neisseria gonorrhoea infections Then again negative trial data is as useful as positive findings, so that we focus resources most effectively #IDSky www.nejm.org/doi/full/10....

Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection | NEJM

No vaccines are currently licensed for the prevention of Neisseria gonorrhoeae infection. Observational studies suggest that the four-component meningococcal serogroup B vaccine (4CMenB) may reduce...

nejm.org

I haven't watched a football match for >24 hours now!!!😱 Life feels so empty.... (thankfully will get my fix again from tomorrow! 😅) #FIFAWorldCup

Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!

Journal of Experimental Medicine@jem.org · 3mo ago

IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (rupress.org/jem/article/...) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @lozanzi.bsky.social highlights the findings: rupress.org/jem/article/...

Great post @apsmunro.bsky.social! Doing more is such a natural reaction. But even 'benign' interventions may likely be harmful when tested properly. I'm yet to know of a trial for sepsis where adding antibiotics has been beneficial (outside of TB where we do it to prevent emergence of resistance).

Alasdair Munro@apsmunro.bsky.social · 4mo ago

My new post looks at two antimicrobials which have been routinely used and even recommended in guidelines despite a lack of RCT evidence In the last few weeks they’ve both been shown to have no benefit, and worse, high probability of harm - killing patients A lesson we keep failing to learn

"As longevity increases in Southern Africa, healthy-ageing interventions for tuberculosis survivors could improve function and survival into older age." #TBSky #IDSky by @kkranzer.bsky.social & team academic.oup.com/jid/advance-...

The 99% probability strapline is very well done .👏

CMI Communications@cmicomms.bsky.social · 4mo ago

🎙️ Just published Communicable E56: Frequentist vs Bayesian for clinical trial analysis – 99% probability you’ll want to listen to this Hosted by Emily McDonald & Josh Davis with invited guests Roger Lewis & Ian Marschner 🌟 Listen on #Communicable: https://share.transistor.fm/s/7ea020d2 #IDSky

A great episode to learn more about the current Ebola outbreak, if nothing else but to learn how to pronounce Bundibugyo #IDSky #IDEpi

CMI Communications@cmicomms.bsky.social · 4mo ago

🎙️ Just published Communicable E55: Bonus episode – Bundibugyo Ebolavirus outbreak Hosted by Angela Huttner and Anne-Grete Märtson with invited guests Daniel Bausch and Martin Grobusch 🌟 Listen on #Communicable: https://share.transistor.fm/s/8750e095

Fascinating paper. Not only association between auto antibodies against immunotegulatory IL-10 and some patients with inflammatory bowel disease. But also association between these antibodies and HLA risk allele for IBD. What's mechanistic link? #immunosky #MedSky www.nejm.org/doi/full/10....

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

nejm.org

Run, cycle, or trek to support those affected by leprosy! Join our challenge events for unforgettable experiences that transform lives. Book your place today: www.lepra.org.uk/events/category/challenge-events #ChallengeEvents #RunForACause #CycleForChange #TrekForGood #MakeADifference