⚠️ REVIEW ALERT 🤓 I'm happy to share our new review, where we discuss recent discoveries on lipopolysaccharide recognition by non-canonical inflammasome and highlight the key questions scientists still need to answer. portlandpress.com/biochemsoctr... Check comments for more details👇

Excited to share this paper from @yiechanglin.bsky.social showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. 🎥🌟 #MDsimulations #StructuralBiology doi.org/10.1016/j.bp...

In Lausanne, we have an incredible environment for research, and our immunology hub is truly thriving! I’m proud to be part of it 👇

Swiss Young Immunologists Society@syis-ecr.bsky.social · 5mo ago

🔥Did you know that the inflammasome was discovered in Lausanne? This groundbreaking discovery in cell signaling was led by Jürg Tschopp’s group at the University of Lausanne (@unil.bsky.social). 🧵(1/9)

Finishing up in snowy Banff with current and former Broz Lab members after the innate immunity symposium. @jakubbegan.bsky.social @kaiwenchen-lab.bsky.social @ehartenian.bsky.social @keystonesymposia.bsky.social

PAPER ALERT! I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity. www.cell.com/immunity/ful... I would like to thank all the co-authors for their valuable contributions. Well done guys! Link for short summary below👇

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation

The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr...

cell.com