Go, Petr, go! The spring conference roll continues, here in Leiden #EMBOpathogenSignalling

Farewell to Adriana from Pablo Pelegrins group - nice to have had you join us for a few months. 🧬🔬

A belated but very well deserved congratulations to postdoc @elliottbernard.bsky.social for his poster prize at the Gordon Cell Death conference! ++ a shoutout to Alexis for his poster and new work!

Finishing up in snowy Banff with current and former Broz Lab members after the innate immunity symposium. @jakubbegan.bsky.social @kaiwenchen-lab.bsky.social @ehartenian.bsky.social @keystonesymposia.bsky.social

Congratulations to @jakubegan.bsky.social, @brozlab.bsky.social et al. A nice reminder that lipid acyl chains are not just defining binding interactions. They tune membrane curvature and flexibility, adding an additional layer of regulation to protein activity and cellular signalling

Jakub Began@jakubegan.bsky.social · 6mo ago

PAPER ALERT! I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity. www.cell.com/immunity/ful... I would like to thank all the co-authors for their valuable contributions. Well done guys! Link for short summary below👇

We’re happy to share our updated manuscript on Ninj1, incorporating measurements of membrane tension, cellular assays of ninj1 and ninj2 dimer stability and MD simulations of ninj1 oligmers opening and forming (see below!). @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles @cp-immunity.bsky.social www.sciencedirect.com/science/arti...

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation

The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

sciencedirect.com

Join us for the upcoming innate immunity keystone. There’s a great lineup of speakers. @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March! keysym.us/KSInnateImmune26 #KSInnateImmune26

Congratulations to (former!) postdoc @ehartenian.bsky.social on launching her career with a prestigious @snf-fns.ch Ambizione grant at the @dib-unil.bsky.social studying how hosts respond to viral infection in her own lab here at the @dib-unil.bsky.social!

Congratulations and welcome to Ella Hartenian @ehartenian.bsky.social, who will be launching her group in our Department of Immunobiology in 2026! www.unil.ch/news/fr/1764...

Trois récipiendaires Ambizione rejoignent la FBM

Cette année, trois jeunes scientifiques viennent renforcer la Faculté de biologie et de médecine (FBM) de l’Unil. Lauréat·es des subsides Ambizione du Fonds national suisse, Ella Hartenian, David Robe...

unil.ch

Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia

The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage Petr Broz @brozlab.bsky.social and colleagues www.embopress.org/doi/full/10....

The week of publications continues for the lab with a @currentbiology.bsky.social piece on ninj1 by @elliottbernard.bsky.social and @ehartenian.bsky.social check it out to have all your pressing ninj1 questions answered :) www.cell.com/current-biol...

Annndddd it’s out! Here’s what came out of combining my virology background with the @brozlab.bsky.social’s cell death focus : a novel role for the cell death protein ninj1 during hsv1 infection. In brief, Ninj1 on mouse macrophages results in lower infection rates and higher cytokine secretion.

Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption @alexandraboegli.bsky.social @embojournal.org link.springer.com/article/10.1...

You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal

The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...

link.springer.com

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online. www.embopress.org/doi/full/10....

NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports

imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...

embopress.org

It’s DIB day! The annual conference for our department @dib-unil.bsky.social. Lovely day (and view!) at the Lausanne Olympic museum exchanging with our colleagues. Plus a stellar presentation on NINJ1 by our own @elliottbernard.bsky.social 🔬!

The second day of the @dib-unil.bsky.social #PRR symposium kicks off with more excellent talks including our own Jakub Began.

Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne! @brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social

Full room at the start of the 2nd Immunobiology symposium on pattern recognition receptors! Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social #ImmunoSky

Are you an excellent researcher in the field of genomics of infectious diseases of intracellular pathogens (viruses, intracellular parasites or bacteria)? The apply for this chair of excellence at the University of Geneva, Faculty of Medicine: jobs.unige.ch/www/wd_porta...

Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!! www.embopress.org/doi/full/10....

Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal

imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1 (CASP1), which complicates interpretation of results in functional studies and limits their clinical potenti...

embopress.org

Here is the latest review from the lab on co infections 🥳. Following up on Philipp’s previous work, Philipp and Petr address what is known and all the open questions in this field : www.embopress.org/doi/full/10....

Molecular mechanisms of co-infections | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

embopress.org

A big congratulations to Dr. Alexandra Boegli for very successfully defending her PhD on listeria activation of the elusive NLRP6! Very well deserved and very well celebrated! 🥳

Registration opens soon for the second Pattern Recognition receptor symposium in Lausanne Switzerland in October 2025. Check out the link for the great list of speakers. wp.unil.ch/immunobiolog...

Congrats to lab member Elliott for winning the poster prize at the Swiss LS2 conference for his work on the activation mechanism of Ninj1 during cell death!! 🥳 @dib-unil.bsky.social @lifesciswitzerland.bsky.social

Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press! www.biorxiv.org/content/10.1...

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...

biorxiv.org

Very happy to share our latest work just published in @jexpmed.bsky.social! #Firstpost rupress.org/jem/article/... Our amazing PhD student @lbernaleau.bsky.social shows that CCDC134 controls TLR biogenesis through the ER-chaperone Gp96. #ImmunoSky #innateimmunity #inflammation Quick summary here:

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

rdcu.be

New manuscript by Sina Bohnacker and Julia Esser-von Bieren published in Science Immunology! www.science.org/doi/10.1126/...

A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis

H. polygyrus glutamate dehydrogenase drives parasite chronicity by epigenetically and metabolically reprogramming host macrophages.

science.org