Imprinting by influenza virus infection in children can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes @nature.com @weillcornell.bsky.social www.nature.com/articles/s41...
Joshua McGrath
@joshuamcgrath.bsky.social
Banting Postdoctoral Fellow at Weill Cornell Medicine | Antibodies, B cell Repertoires, Memory | PhD from McMaster University
Thanks @airr-community.bsky.social for the invitation to share our work on codon optimality in immunoglobulins! www.cell.com/molecular-ce... www.youtube.com/watch?v=WSku...
AIRR C Seminar Series, June 26, 2025 Joshua McGrath, Weill Cornell Medicine, United States
YouTube video by AIRR Community
youtube.com
The next AIRR-C seminar is scheduled for June 26 at 1600 CET, 1000 ET, 700 PT with Rohit Sing @rohitsingh8080.bsky.social (antibody PLMs) and @joshuamcgrath.bsky.social (immunoglobulin codon mutability). Register here: antibodysociety.org/the-airr-com...
AIRR Community Seminar Series - The Antibody Society
Join the AIRR Community for a 90 minute “lab-style” virtual seminar. Each month an established and an early career scientist will discuss their AIRR-seq related research. Seminar time will be 16:00 – ...
antibodysociety.org
Exciting study from the Tan group about a cryptic, immunosubdominant but protective Ab epitope on Plasmodium sporozoites. Generated only through cleavage and pyroglutamation of PfCSP surface protein. Big news for epitope-targeting malaria vaccines and mAb therapeutics www.science.org/doi/10.1126/...
Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein
The most advanced monoclonal antibodies (mAbs) and vaccines against malaria target the central repeat region or closely related sequences within the Plasmodium falciparum circumsporozoite protein (PfC...
science.org
Using protein large language models to optimize antibodies to SARS-CoV-2 with >20-fold increase in binding affinity www.pnas.org/doi/10.1073/... @pnas.org
Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social www.cell.com/molecular-ce...
Mutability and hypermutation antagonize immunoglobulin codon optimality
McGrath et al. investigate the evolutionary relationship between V(D)J mutability, somatic hypermutation, and codon optimality within immunoglobulin repertoires in order to gain a better understanding of how diversification mechanisms might impact antibody expression efficiency.
cell.com