Long Pan
@longpan.bsky.social
Postdoc @Trevor’s lab @icr.ac.uk, PhD@ http://zucmanlab.com | Computational biologist/General surgeon | interested in cancer evolution and cell plasticity in Gastrointestinal cancer, keep curiosity!
Most chromosomal mosaicisms arise after fertilization. We report a child with hepatoblastoma carrying a chromosome 18 rearrangement that instead originated before fertilization. Multi-omics analyses revealed its evolution from gametogenesis to cancer. doi.org/10.1016/j.jh...
Delighted to share my PhD work is now published in Nat Commun! 💯 We established a large HCC dataset including 529 tumors from 461 patients treated in Western countries, integrating WGS/WES, RNA-seq, DNA methylation and proteomics data. www.nature.com/articles/s41...
Integrated genomic analyses identify oncogenic pathway interplay in hepatocarcinogenesis defining specific molecular subtypes - Nature Communications
Precision oncology for hepatocellular carcinoma (HCC) remains challenging due to the high diversity of HCC at the clinical and molecular levels. Here, the authors employ an integrative multi-omics app...
nature.com
In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...
Inferring cancer type-specific patterns of metastatic spread using Metient - Nature Methods
Metient is a statistical framework that infers patterns of metastatic spread and reconstructs cancer migration histories.
nature.com
Open postdoc position in our lab @icr.ac.uk to develop a cfDNA test for #early detection of colorectal #cancer in inflammatory bowel disease #IBD: jobs.icr.ac.uk/vacancies/14... It's bench-to-bedside research, translating biology of pre-cancer evolution. Funded by @bowelcanceruk.bsky.social
Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs in Sutton | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Durati...
jobs.icr.ac.uk
Calling cancer data scientists! 📊 💽 🧮 We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £53,500 (Dependent on experience ) Reporting to: Professor Trevor Gra...
jobs.icr.ac.uk
Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7) rdcu.be/eFrrc
Fluctuating DNA methylation tracks cancer evolution at clinical scale
Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
rdcu.be
Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
nature.com