We are hiring a Project Manager for the National Connectomics and Ultrastructure Volume Observatory (NCUVO) effort: www.uvmjobs.com/postings/88710 For more on NCUVO: www.thetransmitter.org/connectome/b... Thanks!

Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @princetonneuro.bsky.social. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s415... #hippocampus But my personal favorite is (1/2)

Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells - Nature Neuroscience

The authors present a dense connectomic reconstruction of a 0.1 mm3 hippocampal CA3 volume and reveal spatial gradients, high convergence and cell-type-selective feedforward inhibition of inputs to py...

doi.org

It's an exciting day for #Fiji users! Now read and write @zarr.dev v3 and #OMEZarr v0.5. Don't want a million tiny files in your #zarr? Shard that sucker! Read the details here forum.image.sc/t/fiji-can-r...

Fiji can read and write Zarr3 & OME-Zarr v0.5 (new N5 release!)

Updating your Fiji-Latest installation will give you the newest versions of the N5 library, enabling OME-Zarr v0.5 / Zarr v3 support with sharding! What's new? Reading zarr 3 datasets (sharded and u...

forum.image.sc

Brain (and other tissues’) ultrastructure can be resolved with X-ray nanoimaging techniques. If at @fens.org #FENS2026, come to my poster P60 this morning to find out more! 🧠🔬

Excited to see our paper describing a stereotyped receptor map for smell (led by @davidhbrann.bsky.social ) out in the world! See below for short thread with open access link to paper www.nytimes.com/2026/04/29/s...

Scientists Unveil ‘Long Lost’ Map for Smell

nytimes.com

#paper: Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬 doi.org/10.1107/S160... @safekhan.bsky.social @andreas-t-schaefer.bsky.social @crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social

This is who runs this account

Here's a spotlight article on our recent study! Tissue ultrastructure can be resolved with X-rays, which impacts not only how we can study neuronal circuits but soft tissues more generally. Kudos to Ana Diaz, @adrianawanner.bsky.social, @andreas-t-schaefer.bsky.social and all authors.

Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - FocalPlane

Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - News

focalplane.biologists.com

FocalPlane @focalplane.bsky.social · 10mo ago

🔬🔦Our latest ‘Imaging spotlight’, by @carlesbosch.bsky.social, Ana Diaz, @adrianawanner.bsky.social & @andreas-t-schaefer.bsky.social, highlights the non-destructive X-ray tomography pipeline that the authors developed to map mouse brain ultrastructure & considers future applications & developments.

What is psychosis and how can we treat it? Crick group leader @kathaschmack.bsky.social explains how her lab is working to uncover new ways to treat psychosis by finding its biological roots. youtu.be/EUb3_5ecatU

A Crash Course in Psychosis – with Katharina Schmack

YouTube video by The Francis Crick Institute

youtu.be

Method of the Year 2025: In his Comment, Moritz Helmstaedter looks into the future of connectomics and the feasibility of scaling up to larger brains. www.nature.com/articles/s41...

Optimism for abundant whole-brain connectomes and connectomic screening - Nature Methods

Connectomics has so far outpaced the Moore’s law predictions about technological progress. At this pace, many whole-brain connectomes and connectomic screening will soon be realistic.

nature.com

Connectomics is Method of the Year 2025!! @natmethods.nature.com just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...

Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...

Method of the Year 2025: electron microscopy-based connectomics - Nature Methods

A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...

nature.com

And read the associated Research Briefing here: www.nature.com/articles/s41...

Unlocking the potential of X-rays to scale up tissue ultrastructure mapping - Nature Methods

Nondestructively mapping biological tissues in 3D with nanoscale detail is essential to scale up the study of how cells interact in their environment, such as in neuronal circuits. We resolved such ul...

nature.com

An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social www.nature.com/articles/s41...

Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods

Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...

nature.com

Researchers at the Crick, @psich.bsky.social and @esrf.fr have developed a new way to look deeper into brain cell connections by using a particle accelerator and a kind of resin borrowed from the aerospace industry. www.crick.ac.uk/news/2025-11...

From aerospace to neuroscience: new imaging tech captures the brain’s intricate connections

Inspired by technologies used in aerospace engineering, scientists have developed a way to capture the brain’s intricate structures using X-rays without destroying the samples.

crick.ac.uk

Scientists at the Swiss Light Source #SLS and @crick.ac.uk have succeeded in mapping a piece of brain tissue 🧠 in 3D at unprecedented resolution using X-rays – non-destructively. The breakthrough overcomes a long-standing technological barrier that had limited the use of X-rays for such studies.

X-rays bring high-resolution brain mapping within reach

A new imaging breakthrough could reveal brain connectivity in 3D detail never before accessible.

psi.ch

Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...

I was glad to receive a Science Achievement Award from @crick.ac.uk! Thanks!! Cheers to all co-authors of our study showing that tissue ultrastructure can be resolved by X-rays. www.nature.com/articles/s41... And congrats as well to all the other awardees - such a pleasure to be in this lot!

Nondestructive X-ray tomography of brain tissue ultrastructure - Nature Methods

Optimizations of X-ray nanotomography including the choice of resin allows high-resolution imaging of mouse brain tissue, approaching the resolution of volume electron microscopy. Since it does not re...

nature.com

The Francis Crick Institute@crick.ac.uk · 12mo ago

The science achievement award winners were Borzo Gharibi, Bishara Marzook, Paola Peinado Fernandez, Marco Stazi, Claudio Ballabio, Carles Bosch Pinol, Christopher Chan Jin Jie, Jake Cornwall Scoones and Samson Glaser.

Do you have 2D-to-3D image registration challenges? Let me know about them here forum.image.sc/t/toward-bet...

Toward better 2D - 3D registration in BigWarp

BigWarp has so far focused on 2D-2D or 3D-3D registration, and not on 2D-3D registration. After a conversation with @Christian_Tischer , we thought some simple UI changes could make the support for 2...

forum.image.sc

#paper! X-rays can resolve #ultrastructure in tissues non-destructively. www.nature.com/articles/s41... Shoutout to key collaborators at @crick.ac.uk and @psich.bsky.social Ana Diaz, @adrianawanner.bsky.social and @andreas-t-schaefer.bsky.social, and to the whole team that made this possible.

Check these positions at @crick.ac.uk! It’s an outstanding opportunity to shape the way we can map neuronal circuits - and more broadly biological tissues.

Andreas Schaefer@andreas-t-schaefer.bsky.social · 12mo ago

Enthusiastic about connectomics and X-rays? Several positions in our group at Crick for postdocs and senior scientists (permanent!). DM me if interested – and let’s talk if you are at Sfn next days or at the NIH BRAIN CONNECTS meeting today! Please share!

Join us *next Monday*! #CrickXrays25 X-ray #nanoimaging of biological tissues 🇬🇧🌐 @crick.ac.uk & online tinyurl.com/crickxrays25 Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography

Carles Bosch@carlesbosch.bsky.social · last yr.

#Nanoimaging symposium @crick.ac.uk! At #CrickXrays25 we'll tackle: 💫synchrotron upgrades 📈current limits in throughput, volume, resolution 🧪sample preparation for X-ray PC imaging 🧠♥️applications in neuroscience and tissue life science 🗓️13th October 2025 🇬🇧🌐 London & online tinyurl.com/crickxrays25

#Nanoimaging symposium @crick.ac.uk! At #CrickXrays25 we'll tackle: 💫synchrotron upgrades 📈current limits in throughput, volume, resolution 🧪sample preparation for X-ray PC imaging 🧠♥️applications in neuroscience and tissue life science 🗓️13th October 2025 🇬🇧🌐 London & online tinyurl.com/crickxrays25

Hard X-ray imaging of biological soft tissues symposium 2025

tinyurl.com

#preprint: We optimised the preparation of tissues for #X-ray phase contrast imaging. Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images. The process largely preserves #ultrastructure. @safekhan.bsky.social @andreas-t-schaefer.bsky.social

Safe Khan@safekhan.bsky.social · last yr.

Our pre-print is out! Critical point drying of brain tissue for x-ray phase contrast imaging. @apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social @carlesbosch.bsky.social @esrf.fr @crick.ac.uk bioarXiv: doi.org/10.1101/2025...

Wouldn't it be great if we could not only image large connectomic volumes but also completely reconstruct them? And if a whole mouse brain project didn't cost billions? With the PATHFINDER preprint (www.biorxiv.org/content/10.1...), we preview a future where it doesn't have to.

#preprint: We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography. doi.org/10.1101/2025... @yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social @crick.ac.uk @esrf.fr

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The World's Observatory of the Mind | OpenScope

OpenScope is the first astronomical observatory in neuroscience. Scientists across the world can propose new experiments that will be executed freely on the ...

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