A medial entorhinal connectome reveals compartmentalized microcircuit architecture https://www.biorxiv.org/content/10.64898/2026.10.28.762527v1

We are hiring a Project Manager for the National Connectomics and Ultrastructure Volume Observatory (NCUVO) effort: www.uvmjobs.com/postings/88710 For more on NCUVO: www.thetransmitter.org/connectome/b... Thanks!

two new preprints from Wangchu Xiang (@darbly.bsky.social, Ginty labs) about connectomic reconstruction from electron microscopy of somatosensory afferents and projection neurons in the dorsal horn of the mouse spinal cord www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...

Precise structural and functional organization of the olfactory bulb neuropil early in development, revealed by volume EM, dense reconstruction and 2P calcium imaging in zebrafish. Great work by Ruth and others in collaboration with @michalwj.bsky.social www.biorxiv.org/content/10.6...

Fine ultrastructural organization of glomerular neuropil in the developing zebrafish olfactory bulb

Across animal phyla, odor information is represented in the first olfactory processing center by combinatorial activation of discrete glomeruli. To examine how this organization of olfactory processin...

biorxiv.org

A few words about what I’ve been up to at Flourish. Reach out if this resonates with you and you’d like to talk! fewerbetterfaster.substack.com/p/the-parts-...

The Parts List AI Doesn’t Have

Mapping the human brain with light

fewerbetterfaster.substack.com

Applications are now open for the San Juan Winter School 2027 on Connectomics and Brain Simulation! Join us to learn how to analyze and simulate connectomes. sjcabs.com

Very happy our work on a weird new nanoscale morphological feature is out in @science.org. A massive effort involving different high resolution microscopy techniques, multiple institutes, & years of work to convince ourselves DENDRITIC NARROWINGS EXIST #neuroskyence 🧪 doi.org/10.1126/scia...

Dendritic shaft constrictions shape synaptic integration in neurons

For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall’s 3/2…

buff.ly

Just out in Nat Neurosci: disentangling of neural odor manifolds in "olfactory cortex" of adult zebrafish after learning. Great work by Bo, Nesibe et al and wonderful collaboration with @sueyeonchung.bsky.social that fundamentally changed my view of olfactory cortex. www.nature.com/articles/s41...

We are hiring! Start at a #MaxPlanckInstitute with your own independent Max Planck Research Group. This position is equivalent to a W2 Professorship at a German university, or Associate Professor internationally. 🔗Apply until October 14th! www.mpg.de/career/max-p... #ScienceCareer #MPRG #TenureTrack

Ultrastructural reconstruction of hundreds of neurons by volume EM revealed cell types and a precise glomerular organization in the zebrafish olfactory bulb. A heroic effort by Nila! Special thanks to Nila @michalwj.bsky.social and the whole team! www.biorxiv.org/content/10.6...

Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb

Neuronal circuits in the olfactory bulb (OB) perform computations fundamental to pattern classification including a decorrelation and normalization of odor-evoked activity. These computations are medi...

biorxiv.org

Imaging of activity in the telencephalon of adult zebrafish moving through a virtual reality revealed amazingly precise, structured internal representations of spatial environments. And they get better over time! Great work by Kim! Thanks also to Sriram and Jan. www.biorxiv.org/content/10.6...

Dynamic cognitive representations in the dorsal pallium of adult zebrafish

Brains rely on internal models of the world to interpret sensory input and to simulate the future. In the mammalian hippocampal-entorhinal network, environments are represented by cognitive maps that ...

biorxiv.org

New preprint by Tommaso: olfactory cortex (of zebrafish) represents not only odor information but also temporal context, and these multimodal representations are sharpened after learning. And check out Tommaso's new method for 2P imaging in awake adult zebrafish! www.biorxiv.org/content/10.6...

Joint experience-dependent representations of odors and temporal context in the zebrafish homolog of piriform cortex

Intelligent behavior requires experience-dependent internal representations of relevant information. We examined representational learning in telencephalic area pDp of adult zebrafish, the homolog of ...

biorxiv.org

Fish with electrical senses have unique brain cells specifically to process that information. The real trick they pull is separating the electricity they emit from the ones they sense. 🧪 Link: https://www.nature.com/articles/s41586-026-10690-6​

We're thrilled with the publication of the Male CNS Connectome! www.cell.com/cell/fulltex... Also check out this (growing) collection of companion papers: www.cell.com/consortium/m...

I finally got around to posting the HHMI Connectomics Berlin conference snapshots: bryanwjones.com/2026/07/hhmi... Some of ya'll are in here.

Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @princetonneuro.bsky.social. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s415... #hippocampus But my personal favorite is (1/2)

Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells - Nature Neuroscience

The authors present a dense connectomic reconstruction of a 0.1 mm3 hippocampal CA3 volume and reveal spatial gradients, high convergence and cell-type-selective feedforward inhibition of inputs to py...

doi.org

Excited to share our work now in Nature Methods! We wrote this manuscript to help others better analyze and interpret calcium imaging data. As a central aspect, we show why nonlinear behavior of calcium indicators matters in practice. Very happy about this work!

Nature Methods@natmethods.nature.com · 3mo ago

An Analysis from @ptrrupprecht.bsky.social et al investigates the behavior of GCaMP8 variants in spike inference using different algorithms. www.nature.com/articles/s41...

New preprint! www.biorxiv.org/content/10.6... Nearly a decade after starting the project, the first major results from our comparative connectomics work is online! Comparing the head direction circuits of the central complex in bees, ants and flies, recapitulating >300million years of evolution.

Sharing a big update: I started a group at the MPINAT in Göttingen! We will develop AI for analyzing how proteins interact in the cellular environment based on cutting edge imaging. This appointment is in parallel to the university, where I will retain my current group.

MPI for Multidisciplinary Sciences@mpi-nat.bsky.social · 4mo ago

AI meets cutting-edge microscopy: Welcome Constantin Pape, head of our new Machine Intelligence in the Life Sciences group! 👋 🔬 His team develops AI methods to analyze high-resolution microscopy & cryo-EM data to better understand the function of proteins and protein complexes inside cells. (1/3)

Here are my slides for #fens2026 “A versatile and affordable array tomography workflow” https://jekelylab.codeberg.page/FENS_Array_Tomography_Barcelona_July2026.html#/title-slide for the 'Expanding Horizons: Array Tomography in Neuroscience for All' […] [Original post on biologists.social]

Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18

If you’re in or around Baden today, drop by... because Pint of Science Switzerland is back in town for a third time this year! 🧠 "Cracking the Brain's Code" 📆 Today: 19 May, 2026 📍 Kulturhaus Royal, Bahnhofstrasse 39 ⏰ Doors open: 6 PM pintofscience.ch #pintofscience

🧠We offer 1-2 Postdoc positions in Circuit Neuroscience!🧠 Join us at @dandrite.bsky.social to study thalamic circuits for visual processing, funded by an ERC starting grant and the Lundbeck foundation. Deadline: 14. Juni 2026 Apply here: international.au.dk/about/profil...

Our group uses cutting-edge neuroscience technologies and offers an intellectually stimulating and supportive environment. Join the vibrant DANDRITE community, enjoy a lab in walking distance to the baltic sea, a competitive Danish salary, and a lot more ☺️ Learn more: thalamic-circuits-lab.eu

Can generative AI accelerate neuroscience? Excited to share MoGen at ICLR 2026!🧠 We use point cloud flow matching to generate high-fidelity 3D neuron fragments, capturing intricate details like dendritic spines.

This work was a collaborative effort between our lab and clinical experts at UPK Basel. The parallel approach of using mouse circuit and human patient data is likely the most promising approach we have to understanding the mechanism of psychiatric treatments. Full paper: doi.org/10.64898/202...

New preprint with @sevberg.bsky.social! We map Hopfield-like binary networks onto spiking networks with dendrites … and it works! Same memory capacity, bigger basins of attraction, plus selective recall through dendritic gating, and more. How? Dendrites! See below.

Great opportunity to shape the future of X-ray connectomics (and much more 😉): @psi.ch is looking for a new head of the Center for Photon Science www.psi.ch/en/hr/job-op...

Head PSI Center for Photon Science (CPS)

The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences in Switzerland. We design, build and operate the country’s large-scale research infrastructures a...

psi.ch

#paper: Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬 doi.org/10.1107/S160... @safekhan.bsky.social @andreas-t-schaefer.bsky.social @crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social