New preprint! www.biorxiv.org/content/10.6... Nearly a decade after starting the project, the first major results from our comparative connectomics work is online! Comparing the head direction circuits of the central complex in bees, ants and flies, recapitulating >300million years of evolution.

Sharing a big update: I started a group at the MPINAT in Göttingen! We will develop AI for analyzing how proteins interact in the cellular environment based on cutting edge imaging. This appointment is in parallel to the university, where I will retain my current group.

MPI for Multidisciplinary Sciences@mpi-nat.bsky.social · 4w ago

AI meets cutting-edge microscopy: Welcome Constantin Pape, head of our new Machine Intelligence in the Life Sciences group! 👋 🔬 His team develops AI methods to analyze high-resolution microscopy & cryo-EM data to better understand the function of proteins and protein complexes inside cells. (1/3)

Here are my slides for #fens2026 “A versatile and affordable array tomography workflow” https://jekelylab.codeberg.page/FENS_Array_Tomography_Barcelona_July2026.html#/title-slide for the 'Expanding Horizons: Array Tomography in Neuroscience for All' […] [Original post on biologists.social]

Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18

If you’re in or around Baden today, drop by... because Pint of Science Switzerland is back in town for a third time this year! 🧠 "Cracking the Brain's Code" 📆 Today: 19 May, 2026 📍 Kulturhaus Royal, Bahnhofstrasse 39 ⏰ Doors open: 6 PM pintofscience.ch #pintofscience

🧠We offer 1-2 Postdoc positions in Circuit Neuroscience!🧠 Join us at @dandrite.bsky.social to study thalamic circuits for visual processing, funded by an ERC starting grant and the Lundbeck foundation. Deadline: 14. Juni 2026 Apply here: international.au.dk/about/profil...

Our group uses cutting-edge neuroscience technologies and offers an intellectually stimulating and supportive environment. Join the vibrant DANDRITE community, enjoy a lab in walking distance to the baltic sea, a competitive Danish salary, and a lot more ☺️ Learn more: thalamic-circuits-lab.eu

Can generative AI accelerate neuroscience? Excited to share MoGen at ICLR 2026!🧠 We use point cloud flow matching to generate high-fidelity 3D neuron fragments, capturing intricate details like dendritic spines.

This work was a collaborative effort between our lab and clinical experts at UPK Basel. The parallel approach of using mouse circuit and human patient data is likely the most promising approach we have to understanding the mechanism of psychiatric treatments. Full paper: doi.org/10.64898/202...

New preprint with @sevberg.bsky.social! We map Hopfield-like binary networks onto spiking networks with dendrites … and it works! Same memory capacity, bigger basins of attraction, plus selective recall through dendritic gating, and more. How? Dendrites! See below.

Great opportunity to shape the future of X-ray connectomics (and much more 😉): @psi.ch is looking for a new head of the Center for Photon Science www.psi.ch/en/hr/job-op...

Head PSI Center for Photon Science (CPS)

The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences in Switzerland. We design, build and operate the country’s large-scale research infrastructures a...

psi.ch

#paper: Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬 doi.org/10.1107/S160... @safekhan.bsky.social @andreas-t-schaefer.bsky.social @crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social

“We’re hoping doors will open for researchers to ask questions about how connections are made in the brain in mice and maybe, one day, humans.” - @andreas-t-schaefer.bsky.social Read about the new NIH-funded program to map brain circuitry using X-rays: www.crick.ac.uk/news/2026-03...

Can X-rays reveal how the brain is wired?

Neuroscientist Andreas Schaefer is spearheading a new project to capture the intricacies of the mouse brain using X-rays, bringing researchers closer to a complete map of its neural connections.

crick.ac.uk

Exciting new results from our neighbors in the @mace-lab.bsky.social! Using functional ultrasound imaging, they look at brain-wide activity patterns in response to arousing events, showing propagation from subcortical regions to the cortex, and find a surprisingly weak modulation by noradrenaline!

Emilie Macé@mace-lab.bsky.social · 5mo ago

1/8. New preprint! Using fUSi in head-fixed mice🐭, we found that arousal events trigger a brain-wide wave of activity 🌊🧠. Surprisingly, this pattern was preserved during opto manipulations of the locus coeruleus, pointing to a minor role for noradrenergic tone. www.biorxiv.org/content/10.6...

How do fish localize sound without interaural cues? @johve.bsky.social et al. found a behavioral algorithm for directional hearing that predicts behavior from a pressure/motion phase comparison and accounts for how this relationship varies with distance. www.cell.com/current-biol...

An algorithm underlying directional hearing in fish

Veith et al. show how a fish—Danionella cerebrum—can reliably startle away from sound. It uses the relative phase between particle motion and pressure to infer the direction of sound. This sensorimoto...

cell.com

Job alert! Join the Making Lab at the @crick.ac.uk. As a senior engineer in system design, programming, and hardware–software integration, you'll develop systems that make unique experiments possible. More about the role and apply here: crick.wd3.myworkdayjobs.com/External/job...

Senior/Principal Laboratory Research Scientist

Salary for this Role: SLRS: From £45,700 per annum with benefits, subject to skills and experience PLRS: From £55,555 per annum with benefits, subject to skills and experience Job Title: Senior/Princi...

crick.wd3.myworkdayjobs.com

From @bdpedigo.bsky.social: a super efficient, highly reliable, and very generalizable method for mesh structure classification, applied here to spine detection across basically every synapse onto a cell in the MICRoNS dataset.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 6mo ago

A quantitative census of millions of postsynaptic structures in a large electron microscopy volume of mouse visual cortex https://www.biorxiv.org/content/10.64898/2026.02.19.706834v1

The Wiley Foundation is pleased to announce the winners of the 24th annual Wiley Prize in Biomedical Sciences, which recognizes contributions that open new fields of research or advance concepts in a particular biomedical discipline. Learn more: https://ow.ly/ZaiM50YhCF6

In @eLife: Neural connectome of the ctenophore statocyst https://doi.org/10.7554/eLife.108420 Version of record of our ctenophore nerve-net connectome paper.

Neural connectome of the ctenophore statocyst

Volume EM and connectome reconstruction of the apical organ of a ctenophore combined with high-speed imaging reveals a neuronal coordination of balancer cilia in the gravisensory organ.

elifesciences.org

What it's like to be a connectome

Ralph Stefan Weir@ralphstefanweir.bsky.social · 6mo ago

Are earthworms sentient? What about microscopic nematode worms? Or single-celled organisms? Here is a deep dive I wrote for Asimov Press magazine about what investigations at the scale of neurons tell us about sentience. www.asimov.press/p/sentience

The winner of the 2026 Pradel Research Award is H. Sebastian Seung of @princetonneuro.bsky.social! He is being honored for for transformative advances in computational neuroscience. Learn more about his discoveries: www.nasonline.org/award/pradel... #NASaward #neuroscience

What's the relation between voltage and calcium in dendrites? Xiang Wu studied this in CA2 hippocampal pyramidal cells in behaving mice. www.biorxiv.org/content/10.6...

🔬🔦Our latest ‘Imaging spotlight’, by @carlesbosch.bsky.social, Ana Diaz, @adrianawanner.bsky.social & @andreas-t-schaefer.bsky.social, highlights the non-destructive X-ray tomography pipeline that the authors developed to map mouse brain ultrastructure & considers future applications & developments.

Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - FocalPlane

Imaging spotlight: Revealing mouse brain ultrastructure using non-destructive X-ray tomography - News

focalplane.biologists.com

If you are interested in electron microscopy, registration is still open for the "Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples" at Stazione Zoologica in Naples. WIth great teachers from Naples […] [Original post on biologists.social]

Our dispatch: https://www.sciencedirect.com/science/article/pii/S0960982225014691 on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues: #connectomics, without synapses https://www.sciencedirect.com/science/article/pii/S0960982225013090 #neuroscience

How do neural circuits generate the walking rhythm? Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg. w @bingbrunton.bsky.social www.biorxiv.org/content/10.1...

Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!

Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...

Method of the Year 2025: electron microscopy-based connectomics - Nature Methods

A large network of interconnected neurons serves as the basis of brain function and of behavior. Methodological advances have enabled the reconstruction of large-scale and even whole-brain connectomes...

nature.com

Connectomics is Method of the Year 2025!! @natmethods.nature.com just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...