Cool meeting organized by @regenseq.bsky.social on Oct 13 at @nygenome.org on "Repurposed Sequencers, New Experimental Possibilities" regenseq.github.io/meeting
Nicolas Robine 🇪🇺🇫🇷🇺🇸
@nicorobine.bsky.social
Artisanal Genomics since 2002. Mostly in English, sometimes in French. #NoPasaran
Claude discovered a totally new enzyme that was both trivial to find ("first paragraph of a dissertation") and the subject of 4 years of work by a senior PI (who patented it 3 years ago). Go figure...
Did someone check if Feng Zhang spent his weekend in an hotel room instead of attending a conference recently?
Anthropic@anthropic.extwitter.link · 6d agoClaude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR. We don’t yet understand what this system does, but only a handful of known systems share it...
I propose Super Terrific Ultra Platinium Intelligence... Deluxe!
Aaron Rupar@atrupar.com · last wk.Trump tells the UN he is officially changing the name of Artificial Intelligence to "Super Intelligence" and says all US government documents will now be changed to refer to "SI"
Pierre Chambon was one of the driving architects of modern molecular biology, whose scientific vision transformed the understanding of gene regulation in eukaryotic cells. His passing in May 2026 represents the loss of an extraordinary scientist. www.nature.com/articles/s41...
Pierre Chambon (1931–2026) - Nature Genetics
Nature Genetics - Pierre Chambon (1931–2026)
nature.com
🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇
Noncoding transcription controls the developmental dynamics of long-range gene regulation
The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...
science.org
Less corruption, more sailing vessels.
BWJones@bwjones.bsky.social · 2w agoLess corruption, more sailing vessels.
Yesterday’s big game at the US open started at 11pm and finished at 3.30am. On a Tuesday night. What are we doing here? Who is that for? Insanity!
My new book "Curved Air" is officially published today -- in #sicklecellawareness month. The UK launch follows in a few weeks. One anon reviewer said Curved Air is "[the[ book I've always wanted... I wanted to savor it like a good meal.” @harvardpress.bsky.social www.hup.harvard.edu/books/978067...
Curved Air — Harvard University Press
How sickle cell anemia led the quest to edit the human genome while patients endured decades of racial discrimination and medical neglect.In December 1904, Walter Clement Noel, a dental student from G...
hup.harvard.edu
It was great working with students Kun and Ryan and @hannahlong.bsky.social, combing the literature to try and find examples of bona fide disease-causing variants in non-coding elements - promoters, enhancers and silencers. www.nature.com/articles/s41...
Mechanisms underlying disease-causing variants in promoters and enhancers - Nature Genetics
This Review discusses how rare-disease-causing variants in the noncoding genome impact gene regulation, why these examples are so few and how new approaches could accelerate discovery of noncoding var...
nature.com
My cousin’s shirt took me a second. He said “it’s great because anyone who would be offended by it couldn’t understand it anyway.”
absolute fuckers "Trump officials at NIH disclosed the existence of DoD’s efforts only after being pressed for information by House Appropriations Committee Democrats." democrats-appropriations.house.gov/news/press-r...
Defense Officials Attempt to Raid NIH Funds to Cover Department of Defense Activities
House Appropriations Committee Ranking Member Rosa DeLauro (D-CT-03) has learned that officials at the Department of Defense (DoD) are working to divert billions of dollars from the National Institute...
democrats-appropriations.house.gov
"The long return on discovery science in cancer therapeutics" by Cian Murphy, Samuel Hume and @charlesswanton.bsky.social www.nature.com/articles/s41...
The long return on discovery science in cancer therapeutics - Nature Reviews Cancer
Many advances in cancer treatment depend on discoveries made decades earlier. In this Comment, Murphy et al. discuss the histories of EGFR, HER2, CDK4/6 and RAS, highlighting how long translation can ...
nature.com
A Multimodal Foundation Model for Longitudinal Patient Representation and Scalable Insight Generation in Oncology. By Tempus.ai arxiv.org/abs/2608.24688 ("1.67 million cancer patients that integrates clinical trajectories with DNA, RNA, and H&E pathology")
tempus.ai
Long-read sequencing reveals pre-meiotic gene conversion in sperm www.nature.com/articles/s41...
Long-read sequencing reveals pre-meiotic gene conversion in sperm - Nature
Single-molecule long-read sequencing of human sperm reveals variation in recombination across donors and that a substantial fraction of non-crossover gene conversions arises before meio...
nature.com
Congratulations to our Core Faculty Member @landau.bsky.social Full story: www.nygenome.org/news-events/... lnkd.in/p/g8UX_CfM
Dr. Dan-Avi Landau, a world-renowned cancer researcher and pioneering geneticist, has been appointed inaugural chair of the newly created Department of Systems and Computational Biomedicine. The new…...
Dr. Dan-Avi Landau, a world-renowned cancer researcher and pioneering geneticist, has been appointed inaugural chair of the newly created Department of Systems and Computational Biomedicine. The new ...
lnkd.in
Perfect opening of a book right after moving our daughter to college. Too tired to read it all tonight, but it’s a book I wanted to read for a while.
Last week, we celebrated the conclusion of our 2026 MacMillan Summer Internship Program! 🧬 Congratulations to our talented interns, and thank you to the mentors, faculty, and staff who supported them throughout their summer at NYGC. 🎓🔬
Unlocking a new adventure in the American experience: driving Kid #1 to college… North Carolina, here we go!
This weekend, I sailed to the NYC Harbor through the East River. Something like the first image. But for fun, we also asked Gemini (2) and ChatGPT (3) to draw a map of our cruise. And they failed pretty spectacularly!
This weekend, I sailed to the NYC Harbor through the East River. Something like the first image. But for fun, we also asked Gemini (2) and ChatGPT (3) to draw a map of our cruise. And they failed pretty spectacularly!
Question: do I know anyone near Nantes who would be willing to pick up a dead gull-billed tern and its logger? L49 has sadly been killed near a road. I’d be very grateful for a picture and the logger and would of course reimburse postage.
ICYMI: New online! Embracing non-linearity in human ageing
Embracing non-linearity in human ageing
Nature Reviews Genetics, Published online: 03 August 2026; doi:10.1038/s41576-026-00993-9Ageing has often been conceptualized as a gradual, linear decline, yet growing evidence suggests it unfolds through dynamic, stage-specific transitions. In this Perspective, the authors examine such evidence across molecular and physiological systems and discuss analytical frameworks to identify non-linear transitions.
dlvr.it
Hot off the press in Nature! After 10 years, 2,780 patients and 300+ scientists, today we announce the Human Cancer Models Initiative (HCMI) release of 665 organoids and other next generation models! All models and data available to accelerate cancer drug discovery! @nature.com rdcu.be/fx3I3
A compendium of next-generation patient-derived models for diverse cancers
Nature - The international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 cancer types and...
rdcu.be
We're proud to share this important work, with contributions from NYGC scientists, Nicolas Robine, William Hooper, Tim Chu, and Jennifer Shelton. This transformative resource will help advance cancer research and accelerate scientific discovery @nicorobine.bsky.social x.com/CSHL/status/...
Cold Spring Harbor Laboratory (@CSHL) on X
The next generation of cancer research models has arrived. An international consortium led by CSHL and @NorthwellHealth has developed more than 150 organoid models representing actual patient tumors s...
x.com