Reverse molecular pharmacology identifies the non-canonical axis of IRAK as a chemoresistance factor in neuroblastoma https://www.biorxiv.org/content/10.64898/2026.01.09.697473v1
Marion
@marionlegrand.bsky.social
PharmD, PhD, childhood cancer biology and experimental therapeutics 👩🏻🔬🔬💊, member of REACT-4Kids - mindset is everything ❣️🍀
Reverse molecular pharmacology identifies the non-canonical axis of IRAK as a chemoresistance factor in neuroblastoma https://www.biorxiv.org/content/10.64898/2026.01.09.697473v1
Depuis plusieurs années, le mois de septembre est dédié à la lutte contre les cancers de l’enfant, de l'adolescent et du jeune adulte (AJA). Pour parvenir à guérir plus et mieux, parlez en autour de vous et faites entendre la voix des enfants malades.
This study is another POC for the interest of our program realized through @southrock.bsky.social evaluating the physical activities in children diagnosed with cancer. Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | New England Journal of Medicine www.nejm.org/doi/full/10....
Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM
Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...
nejm.org
One picture is worth a thousand words
Eddy Pasquier 🧪🇫🇷🇦🇺@eddpasquier.bsky.social · last yr.Jusqu’ici tout va bien…
📣 Youth4Kids 2025 🎗️ @r4knetwork.bsky.social This morning, we had the pleasure to welcome Dr Clara Savary from @hmriaustralia.bsky.social. She is currently working on deciphering the resistance mechanisms of ONC201 in DIPG. Well done Clara and the whole team led by Dr Matt Dun. 👏
📣 Youth4Kids 2025 🎗️Best young researcher talk 🤩 Second part of the contest. Five new candidates will be presenting their work. @r4knetwork.bsky.social
📣 Youth4Kids 2025 🎗️Best young researcher talk 🤩 This year, 10 candidates will be presenting their work. They will be judged by young postdocs from the @r4knetwork.bsky.social. We are starting this morning with 4 PhD candidates. Good luck to all candidates.
📣 Youth4Kids 2025 🎗️ Let's start with @guixe-m.bsky.social from @irbbarcelona.org. Her work focuses on the origin of second malignancies in children or the factors underlying the response to immunotherapies. Looking forward to listening to her talk! @r4knetwork.bsky.social
Here we go again!! 🤩 Today is the first day of Youth4Kids 2025!!! An online congress organized by the young researchers of @r4knetwork.bsky.social. Great keynote speakers, selected talks from young researchers and the highlight of the event, the Youth4Kids Doctoral Grant Competition!!!
In this week’s publication highlights, we picked this study just out @naturemedicine.bsky.social describing an innovative method for the rapid classification of brain tumors based on molecular profiling. Congrats to all involved @dkfz.bsky.social and beyond 👏🏻 www.nature.com/articles/s41...
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors - Nature Medicine
Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling w...
nature.com
Looking for heart shapes in the lab and in life in general. Life is full of beauty. Notice it.
Eddy Pasquier 🧪🇫🇷🇦🇺@eddpasquier.bsky.social · last yr.One day I’ll be able to take beautiful pictures of cells and reveal their inner workings like @christlet.bsky.social. Until then, I’ll keep looking for heart shapes in tumor spheroids to please @marionlegrand.bsky.social. Congrats to Florent, our Master student, for this great entry
For the first time of the year, the whole team got together for the #REMAP4Kids Mini-Symposium. Full afternoon of short presentations to highlight the different projects ongoing in the team. Very exciting to see how our team is progressing over the years, thanks to our collaborations & funders.
Today, members of @r4knetwork.bsky.social gave presentations to school pupils all across the country. We’re teaching young kids about medical research & what it means to be a scientist. Always a great pleasure and even more so with our brand new lab member @mathilde-krh.bsky.social 🤩.
Chaque année au mois de Mars, sous l’impulsion 2500 Voix les chercheurs du réseau React4Kids se mobilisent pour sensibiliser les enfants des classes primaires et collèges sur la recherche, le cancer et leur donner envie de s’engager dans des métiers au service des autres.
Our collabs are the best! Headed by Laura Broutier from CRCL & funded by INCa, this collaborative project uses patient-derived tumoroids, drug screening and mathematical modeling to develop more effective treatments for #Rhabdomyosarcoma. This is so @southrock.bsky.social 🤩
Every single one of these meetings is an absolute pleasure. I feel privileged to coordinate this Center of Excellence with @marie-castets.bsky.social and to get to build collaborative projects with the likes of @cedricmaurange.bsky.social @delloye-bourgeois.bsky.social & many more not on BlueSky.
SouthROCK@southrock.bsky.social · last yr.Yesterday, we held one of our regular steering committee meetings with all the clinicians and researchers in charge of our scientific program. The occasion to reflect on our first year of existence and prioritize our actions for year 2. Watch this space in 2025!
It’s the start of a new week. But we still want more labcoats and less white robes. We need to keep standing up for science! @standupforscience.bsky.social @marionlegrand.bsky.social @rafajarguello.bsky.social @cnrs.fr @inserm.fr @univ-amu.fr @crcm.bsky.social @ciml.bsky.social #Medsky
Today is the International Women's Day 2025. The world we are currently living in scared me a little more every day, but collectively, I still do think that we can make a difference. I wish we could live in a gender equal world. #IWD2025
Today, I protested against Trump administration’s science policies. Science, all types of science, shapes our world, our futur world. We need to protect it. Science always matters. @standupforscifr.bsky.social @crcm.bsky.social @cnrs.fr @inserm.fr
More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025
Je serai présente au rassemblement marseillais du mouvement #StandUpForScienceFrance ce vendredi. Mobilisons nous pour défendre les sciences et les humanités, la liberté académique, la recherche et l’enseignement.
Glad to have contributed to this beautiful work led by @celiarouault.bsky.social & colleagues at @crcm.bsky.social just out in @naturecomms.bsky.social. Using drug repurposing, they unveiled the STAT3/FanA axis as a targetable vulnerability in breast cancer stem cells www.nature.com/articles/s41...
Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer - Nature Communications
Targeting cancer stem cells (CSCs) has great potential in anti-cancer treatment. Here this group reports the role of antibiotic Nifuroxazide as a potent anti-CSC compound and fabricates it into an ant...
nature.com
Today, all 3 centers of excellence in pediatric oncology research were invited by INCa to present what they have been up to during their first year of existence. We were delighted to showcase everything we have put in place, including our beloved #RockBands, ongoing and upcoming projects.
ALERT NEW COMER!! @r4knetwork.bsky.social, the French network for basic and translational research in pediatric oncology is finally on @bsky.app 🎉 We will be posting all our upcoming events, including free webinars & annual conferences, as well as new publications, job ads… So, watch this space 👀
React4Kids@r4knetwork.bsky.social · last yr.Our free webinars are back! Today we had the pleasure of listening to Dr Ulrich Schüller from the Research Institute Children’s Cancer Center Hamburg, talking about his work on the molecular diversity of spinal ependymomas.
Our free webinars are back! Today we had the pleasure of listening to Dr Ulrich Schüller from the Research Institute Children’s Cancer Center Hamburg, talking about his work on the molecular diversity of spinal ependymomas.
Retour en images sur la journée du 15 Février et la petite sortie des coureurs amateurs du @crcm.bsky.social pour rendre hommage aux 2500 enfants diagnostiqués avec un cancer chaque année en France. Un beau moment de partage et de sensibilisation youtu.be/Nm66kbd8_Vk?...
✦ REPORT ✦ 2500 VOIX ✦ ENGAGEMENT ✦ Strava Drawing
YouTube video by Serge Fortini
youtu.be
Today is the international day against childhood cancer. To honor the 2,500 children and adolescents diagnosed with cancer each year in France, scientists from @crcm.bsky.social, @aphm-chu-marseille.bsky.social & @inp-marseille.bsky.social ran 15km this morning in Marseille to draw 2500 in GPS 💪🏻
