Hey "Friends" The 2025 edition of our #AwkwardLabPhoto celebrates an incredible year of growth, publications, promotions, PhD submissions and grads I feel immensely proud and grateful to be part of this team

How do cytokines tune immune helpers? Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity. 🔗 www.nature.com/articles/s41... #Immunology #SpatialBiology

Thanks @10xgenomics.bsky.social for the shout out and for making your data publicly available Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go (Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)

Millennium Science@mscience.bsky.social · 10mo ago

How do cytokines tune immune helpers? Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity. 🔗 www.nature.com/articles/s41... #Immunology #SpatialBiology

"Biology is messy and sometimes we need to embrace the mess" www.nature.com/articles/s41... Huge thanks to Amy Weinmann and Danielle Chisolm for beautifully highlighting our work and the importance of our approaches @natimmunol.nature.com

TFH cell programs by pathogen and species - Nature Immunology

CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, rather than pathogen class, shape diversity in programming potential.

nature.com

Thrilled to make the cover of @natimmunol.nature.com this month. A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social

WEHI scientists led by @groomlab.bsky.social‬ @chinweetan.bsky.social map how Tfh cells tailor instructions based on infection type. A step toward smarter vaccines and therapies. 📄 In @natimmunol.nature.com: www.nature.com/articles/s41... 🔗 Read more: www.wehi.edu.au/news/unlocki...

Great work by @chinweetan.bsky.social , @Len Dalit and @groomlab.bsky.social and her team understanding the signatures behind T folicular helper heterogeneity! ⬇️ #ImmunoSky

Joanna Groom@groomlab.bsky.social · 11mo ago

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...

nature.com

Thrilled to share our latest publication! Huge thanks to the team @chinweetan.bsky.social, Melissa Davis, Ahmed Mohamed and @bhuvad.bsky.social for making this possible! Questions welcome! Would love to hear your thoughts on our approach!

@chinweetan.bsky.social · last yr.

Very excited that our work is out in Bioinformatics! mastR: an R package for automated identification of tissue-specific gene signatures in multi-group differential expression analysis academic.oup.com/bioinformati... @wehi-research.bsky.social led by the talented Jinjin Chen

Very excited that our work is out in Bioinformatics! mastR: an R package for automated identification of tissue-specific gene signatures in multi-group differential expression analysis academic.oup.com/bioinformati... @wehi-research.bsky.social led by the talented Jinjin Chen

mastR: an R package for automated identification of tissue-specific gene signatures in multi-group differential expression analysis

AbstractMotivation. Biomarker discovery is important and offers insight into potential underlying mechanisms of disease. While existing biomarker identific

academic.oup.com

Super glad to me part of this great team and work! Amazing!

Joanna Groom@groomlab.bsky.social · last yr.

This journey was over 2.5 since initial submission 😭 led by @benjbroom.bsky.social with support from the whole lab, @chinweetan.bsky.social, WEHI’s Dynamic Imaging Facility, and Norbert and Colin's teams.

Very excited our work out in @jem.org “Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection” @wehi-research.bsky.social led by talented (and determined) PhD student @benjbroom.bsky.social Thread below.

Journal of Experimental Medicine@jem.org · last yr.

@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...

@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...

Have seen lab mates come and go but a great group to end 2024 with. I don't like it when some mention they were finishing grade 6 when I was starting in my role here though....

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

Method of the Year 2024: spatial proteomics - Nature Methods

Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.

nature.com

#Multiomics2024 was amazing and I was very proud to be invited to speak for @standardbiology.bsky.social. Here’s the cartoon version. Huge thanks to @aruthak.bsky.social for bringing it all together. #spatialbio