🧬 How do immune disease-relevant variants affect gene regulatory networks in CD4+ T cells? 🧪🖥️ We coupled two large-scale CRISPRi screens (>4M cells) to map the downstream cascades of thousands of SNPs More details in the thread below 👇 or in the article 📖 on biorxiv tinyurl.com/CD4screens

Very proud to see this work out on bioRxiv. Using genome-scale TAP/Perturb-seq we mapped the function of immune-disease variants to target genes and regulatory cascades. Have a look at the 🧵from @anniquec.bsky.social for more info!

Annique Claringbould@anniquec.bsky.social · 5mo ago

🧬 How do immune disease-relevant variants affect gene regulatory networks in CD4+ T cells? 🧪🖥️ We coupled two large-scale CRISPRi screens (>4M cells) to map the downstream cascades of thousands of SNPs More details in the thread below 👇 or in the article 📖 on biorxiv tinyurl.com/CD4screens

A new lab preprint is up: Work led by our MSc student Jan Sprengel comparing Interventional Causal Structure Learning Algorithms for Gene Regulatory Network Inference from single cell CRISPR perturbation screens 👇 www.biorxiv.org/content/10.6...

Comparison of Interventional Causal Structure Learning Algorithms for Gene Regulatory Network Inference

Background: Causal structure learning offers a promising approach to studying gene regulation in cells, aiming to provide deeper mechanistic insights than purely association-based methods. Theoretical...

biorxiv.org

Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...

A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines

Feng et al. present the first genome-scale CRISPR interference perturbation map with scRNA-seq readout across many genetic backgrounds in human pluripotent cells, pioneering population-scale CRISPR pe...

cell.com

We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...

Auszeichnung für Heidelberger Datenwissenschaftlerin: Britta Velten wird für innovative Verfahren für die Analyse von komplexen Datensätzen aus den Lebenswissenschaften mit dem Early Excellence in Science Award ausgezeichnet www.uni-heidelberg.de/de/newsroom/... #uniheidelberg #lifescience

Extremely honoured to receive the Bayer foundation early excellence in science award. Thanks to all my team, colleagues, collaborators and mentors for making this possible!

Universität Heidelberg@uniheidelberg.bsky.social · 10mo ago

Award for Heidelberg Data Scientist: The Early Excellence in Science Award goes to Britta Velten for innovative procedures in the analysis of complex data sets from the life sciences www.uni-heidelberg.de/en/newsroom/...

Was fun to be part of this!

Junyan Lu@junyanlu.bsky.social · 10mo ago

Huge thanks to our collaborators — Britta Velten (@brittavelten.bsky.social) , the Klingmüller lab at DKFZ (@klingmuelab.bsky.social), and the Winter team at Thoraxklink Heidelberg — for their contributions 🙏 We invite you to try out msBayesImpute and welcome any feedback or suggestions! 💬

Very nice framework to handle missing values in proteomics data by combining probabilistic factor models (alike MOFA) and suitable likelihood functions to account for values missing not at random. Take a look 👇

Junyan Lu@junyanlu.bsky.social · 10mo ago

🚀 Excited to share our new preprint: msBayesImpute - A Versatile Framework for Addressing Missing Values in Biomedical Mass Spectrometry Proteomics Data 👉 Improves imputation accuracy, normalization, and differential expression detection 📝https://www.biorxiv.org/content/10.1101/2025.10.02.679746v1

Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems? Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Are you an AI expert who wants to stay in academia and change the world by understanding the most complex things we know - living organisms? Want to lead your own group, based in Heidelberg DE, working language English? @embl.org is hiring in AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader – AI in Biology

Are you ready to lead groundbreaking research in AI for Biology? Join us at EMBL! We are seeking a visionary scientist to establish their own independent research group bridging innovations in machine...

embl.wd103.myworkdayjobs.com

Welcome to day 4 of #EMBOBioImage 🖥️ 👉Happening right now: practical session 5, spatial statistics and omics integration, led by @brittavelten.bsky.social, assisted by Anna Klemm.

And here we go again with Day 4️⃣ of the @embo.org course on "Advanced methods in bioimage analysis"! 🔬🖥️📊 We just started "Pratical session 5: Spatial statistics and omics integration" with @brittavelten.bsky.social and her team 💪 from @uniheidelberg.bsky.social ...

🔬 PhD Position in Bioinformatics! Join my group at Heidelberg University (lu-group-ukhd.github.io) to study AML dormancy & therapy resistance using multi-omics & single-cell data. 👉Apply or share: www.jobvector.de/job/bioinfor...

PhD Student Bioinformatics, Computational Biology (m/f/d)

Analyze bulk and single-cell multi-omics data generated from in vivo AML models Curate and integrate public datasets (eg scRNA-seq) to derive prior knowledge on AML dormancy Develop and apply integrat...

jobvector.de

Exciting kick-off meeting for our spatial omics seminar in and around Heidelberg organised with @tanevski.bsky.social and @denisschapiro.bsky.social. Was fun to see all the cool research happening here and connect. Reach out to us if you missed out and would like to join the next meetings!

🚀 Job opportunity: Bioinformatics Software Engineer Join a young and passionate team at Heidelberg University to advance bioinformatics software that drive biological discovery. Learn more & apply 👉 shorturl.at/GCpg7

Bioinformatics Software Engineer

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

shorturl.at

Looking forward to meeting up with the spatial biology community in October! Join us in Heidelberg :-)

EMBL Events@events.embl.org · last yr.

🌟We're glad to announce that the brand new EMBL Conference #EMBLSpatialBiology is now open for registration ➡️ https://s.embl.org/spb25-01-bl Submit your abstract by 8 July and be part of the rapidly growing spatial biology community! 🗓️ 14 – 17 October 📍 EMBL Heidelberg and Virtual #ESSB2025

Do you want to advance scientific software for the life sciences? Join us now in Heidelberg as a scientific software developer. Details can be found here: shorturl.at/vqpEA

Scientific Software Developer

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

shorturl.at

JOB OPPORTUNITY: Join us as a scientific programmer to advance tools for multi-omics data at Heidelberg University. Details can be found at shorturl.at/OcnOa and please spread the word!

CompBio method developers: software that only runs on your computer and is not available via a repository like CRAN, PyPI, Bioconductor, is not a proper research output — just like a set of scribbled notes on your desktop is not the same as a preprint or a paper. Finish the job.

My first post here on BlueSky to share our recent work with Claudia Feng and @leopoldparts.bsky.social - a large-scale single cell CRISPR screen to chart out gene regulation and the role of genomic background in iPSCs. Check out the data here: www.sanger.ac.uk/tool/crispri...

Leopold Parts@leopoldparts.bsky.social · 2y ago

Does my mutation have the same impact as yours? Population genetics 🤠 🥸 🤓 🤡 meets single cell CRISPRi ⚡ ! www.biorxiv.org/content/10.1... Led by Claudia Feng, Oliver Stegle, Britta Velten, @sangerinstitute.bsky.social .