EMBL's new AI unit is recruiting. We are seeking a machine learning scientist to establish their independent research group bridging innovations in machine learning/AI with modern biology. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

22/n On a personal note, I’ll soon start an independent research group in the Genome Biology Unit at EMBL Heidelberg. If you enjoy this type of work and want to engineer genomes at the largest scale, please reach out! jonas-koeppel.github.io/koeppellab/ www.embl.org/groups/koepp...

A must read for anyone who cares about eukaryotic genomes

Jonas Koeppel@jonaskoeppel.bsky.social · 4mo ago

1/n What fraction of the human genome is essential for cells? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay.bsky.social @jshendure.bsky.social www.biorxiv.org/content/10.6...

Postdoctoral job announcement: come to Cambridge and work on population genetic modelling with environmental and ancient DNA, jointly with @gamzeandgursoy.bsky.social and me. Details at www.jobs.cam.ac.uk/job/55580/ - applications by June 16th.

⚠️ new preprint: Chromatin accessibility of primary cancers informs regional mutagenesis in metastases through multi-scale deep learning. led by @hanlijiang13.bsky.social @moleculargenetics.bsky.social @oicr.on.ca www.biorxiv.org/content/10.6... [1/3]

1\ Excited to finally share some of my PhD work: OpenSplice! We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.

bioRxiv Genomics@biorxiv-genomic.bsky.social · 5mo ago

OpenSplice: the impact of half a million mutations on the alternative splicing of 600 human exons https://www.biorxiv.org/content/10.64898/2026.05.22.727141v1

Genetic analysis of circulating metabolic traits in 619,372 individuals @nature.com @kauralasoo.bsky.social @unitartupress.bsky.social www.nature.com/articles/s41...

"In this study, we present a genome-scale map of genetic interactions in the human haploid cell line HAP1, based on CRISPR-based perturbation of ∼4 million gene pairs. The resulting network comprises ∼89,000 high-confidence gene-gene interactions" doi.org/10.1016/j.ce...

Indeed.. here is "generate the first page of a great Nature paper that will get lots of citations. It must be very novel."

We Are on the Cusp of a Revolution in Rare Disease Treatment www.nytimes.com/2026/04/09/o...

Opinion | This May Be the Most Important Medical Story of the Decade

nytimes.com

+1 to perhaps not utopian relabeling the world, but gently moving to directly describing the mutation impact in biophysical terms as destabilizing, aggregation-inducing, interface-destroying, etc.; and the higher level phenotypes as a function of these protein qualities, not of mutations!

Tobias Warnecke@tobiaswarnecke.bsky.social · 6mo ago

I wrote an essay. It’s about gain-of-function mutations. And penguins. Also ion channels, chihuahuas, the film Alien, recycled cardboard, and the Apollonian mind. Oh, and muffins. Thanks to the editors of #GENETICS @genetics-gsa.bsky.social for letting me take some stylistic liberties. 1/2

AI x BIO 2026, 8-10 June Submit an abstract now! >450 registered last year coursesandconferences.wellcomeconnectingscience.org/event/ai-x-b...

Do you plan to analyse lots of genomes? Or few that are large? One or multiple species? Join us for the course on analysing data at scale! (and yes, it will involve a lot of k-mers!). With @katiejenike.bsky.social and others... @sangerinstitute.bsky.social @connectingscience.bsky.social

A big thank you to everyone who attended in-person and online our One-day meeting: David MacKay: Energy and Information on Friday. @cambridgephysics.bsky.social @eng.cam.ac.uk An unedited live-stream is available to watch on YouTube: youtube.com/live/unuuHyd...

🧬 We're hiring scientists! I'm building a new team at the Generative Biology Institute, Ellison Institute of Technology Oxford, next to colleagues in AI, Robotics, and Plant Biology.

Great to present our work on MAVEs as part of www.ebi.ac.uk/perturbation... at #VariantEffect26 - always a very enjoyable meeting!

Atlas of Variant Effects Alliance@varianteffect.bsky.social · 7mo ago

On stage now is Alistair Dunham of the Wellcome Sanger Institute with a talk about the standardization and joint analysis of 2041 MAVEs. #VariantEffect26 #MAVEs #AtlasOfVariantEffectsAlliance

Meet evedesign: open-source AI, accessible protein design ✅Combine models for multiobjective optimization ✅Integrate experimental data ✅ Run on your own infrastructure 📄Paper: www.biorxiv.org/content/10.6... 💻Code: github.com/evedesignbio 🌐Webserver: evedesign.bio Collaborate: hello@evedesign.bio

evedesign: accessible biosequence design with a unified framework

Unified protein design for computational researchers and experimentalists

deboramarkslab.substack.com

Join us on the 27 March for our One-day meeting: David MacKay: Energy and Information. @cambridgephysics.bsky.social @eng.cam.ac.uk 27 March 2026, 09:00 – 17:45 Details and booking: www.cambridgephilosophicalsociety.org/events/event...

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations" Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations? rdcu.be/e7zx7

Gene regulatory networks: from correlative models to causal explanations

Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

rdcu.be

Now published! www.cell.com/cell-systems...

The modifiers that cause changes in gene essentiality

A systematic study of gene essentiality across 18 genetically diverse natural yeast strains identifies 39 genes that are essential in the laboratory reference strain but not in at least one other gene...

cell.com

Jolanda van Leeuwen@jsvanleeuwen.bsky.social · 2y ago

Some science news to brighten up your timelines ☀️ Our latest work on the modifiers that cause changes in gene essentiality between genetic backgrounds, now on bioRxiv: www.biorxiv.org/content/10.1... So what did we find?

New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.

Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

Somatic and germline mutational processes across the tree of life https://www.biorxiv.org/content/10.64898/2025.12.28.691837v1

Are you interested in biodiversity genomics? Fantastic opportunity to join us as a Group Leader at the Tree of Life Programme, @sangerinstitute.bsky.social. 👇 sanger.wd103.myworkdayjobs.com/en-GB/Wellco...

New preprint from our lab, spearheaded by @maelledaunesse.bsky.social and in collaboration with Diego Villar! In which we ask, can we detect joint signatures suggestive of positive selection on transcriptomes and epigenomes?

Maëlle Daunesse@maelledaunesse.bsky.social · 10mo ago

We've just released our new preprint! 🐀✨ doi.org/10.1101/2025... How do gene expression and regulation evolve during adaptation? And how can we tell adaptive shifts apart from simple drift? @camilleberthelot.bsky.social 👇 A short thread on what we found in African mole-rats.

A key step towards human genome synthesis. With thanks to @wellcometrust.bsky.social @mrclmb.bsky.social #SynHG doi.org/10.1126/scie...

High-fidelity human chromosome transfer and elimination

The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...

doi.org

please share this postdoc job alert! come join the budding Biodiversity Cell Atlas initiative as a postdoc or senior postdoc at @sangerinstitute.bsky.social working closely with @arnausebe.bsky.social and me to make progress on what we cover in this paper www.nature.com/articles/s41...

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution - Nature

The Biodiversity Cell Atlas aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life, which will be phylogenetically informed, rely on high-quality genomes and use...

nature.com

Claudia Feng's Ph.D work is now out, co-led with @brittavelten.bsky.social and @steglelab.bsky.social . Large-scale CRISPRi perturbations in genetically heterogenous iPSC lines, with single cell readout - enjoy :)

Britta Velten@brittavelten.bsky.social · 10mo ago

Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...

⚠️New study: we mapped DNA-binding of topoisomerase TOP2B in cancer, uncovering surprising hotspots of DNA damage. TOP2B, normally essential for DNA stress relief, can act as a double-edged sword. co-led by @LiisUuskula @ChristianLee, out now @natcomms.nature.com www.nature.com/articles/s41... [1/7]

Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes - Nature Communications

Topoisomerases resolve topological DNA stress via double-strand breaks and are established targets of cancer chemotherapies. Here, the authors link genomic binding of TOP2B with localized mutational p...

nature.com