Amar Sahay
@amarsahay.bsky.social
Professor @ MGH & Harvard Medical School. Hippocampus + Cognition. www.sahaylab.com Engineering strategies to restore, maintain and enhance cognition since 2011. (U)Marathoner. Shark diver. Husband. Dad of human and wirehaired doxies
Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...
Amazing! Allelle-specific ASO-dependent disease modifying effects in 9 and 14 year old Ms carrying causal SCN2A (GOF and LOF/mixed variants): Ameliorative effects seen on seizures, cognitive impairments, autistic behaviors, + autonomic (GI) dysfunction! www.nature.com/articles/s41...
Individualized antisense oligonucleotides for SCN2A-related developmental epileptic encephalopathy - Nature Medicine
In two patients with SCN2A epileptic encephalopathy, treatment with personalized allele-selective antisense oligonucleotides led to a decrease in seizure frequency with a positive safety profile.
nature.com
Anyway you cut it, the match of the last five decades! Inglaterra y Argentina: Avenging the hand of God. Period. Karma! Boom!
We have a new preprint! By studying neuronal heterogeneity in CA3, we found a weird but powerful new feature in the hippocampal circuitry! 🧠 #neuroskyence 🧵.. Morse-Mora et al. | Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans doi.org/10.64898/202...
Shark week coming up: Wait for your moment of Zen. Location: Off NC coast, sunken U352 is a feeding station / haven for these beautiful sand tigers. Water temps: 75-80F, Depth 80-120 feet. Nitrox.
The choice to VAR Is what makes it subPAR Many a goal is denied And ruling decried. Even Ogden Nash Wouldnt bet Cash On a VAR bet Without Regret.
Var Vargr: Blue Flame Skull
ALT: Var Vargr: Blue Flame Skull
static.klipy.com
Sad and painful to see the cost of assault on graduate programs in Biomedical Research across our nation. We MUST regain our trajectory before it is too late. #sciencematters Research Universities Are Admitting Fewer Ph.D.s, a Bad Sign for Science www.nytimes.com/2026/07/06/u...
Research Universities Are Admitting Fewer Ph.D.s, a Bad Sign for Science
nytimes.com
📣 Thrilled to share our recent work in @natneuro.nature.com. Using direct recordings from the human hippocampus and visual cortex, we asked how the brain prepares to encode information when upcoming events are unpredictable, and what ripples do in that process. www.nature.com/articles/s41...
Human hippocampal ripples tune cortical responses based on predicted uncertainty - Nature Neuroscience
Using direct recordings from the human brain, Frank et al. show that hippocampal ripples increase ahead of unpredictable events and tune the visual cortex to respond faster and more strongly to surpri...
nature.com
Incredible energy but even the light from a higher authority couldn’t save Scotland from a stronger Morocco. @fifaworldcup-x.bsky.social
A terrific must listen podcast for all trainees at all career stages in science (and highschoolers and UGs). DO NOT OUTSOURCE YOUR THINKING to AI. 1/n podcasts.apple.com/us/podcast/w...
What 400,000 Essays Reveal About AI and Creativity
Podcast Episode · Plain English with Derek Thompson · June 5 · 56m
podcasts.apple.com
Watching England win this battle decidedly (against Croatia) where they lost that other war (Buckman Tavern, April 19, 1775, Lexington, MA). @ FIFA @onlyinbos.bsky.social
Beautiful work. Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of fragile X mice and identifies EPAC2 as a therapeutic target: Neuron www.cell.com/neuron/fullt...
Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of fragile X mice and identifies EPAC2 as a therapeutic target
Suresh et al. profile the translatomes of excitatory and parvalbumin neurons in fragile X syndrome mice and identify Rapgef4/Epac2 as the only gene that is synaptic, an FMRP target, and an NDD candida...
cell.com
The poignant vignettes in this book from many years ago reminds us that snipping viscera and tissue for therapeutic relief will gradually become a thing of the past…as snipping nucleic acids and biologics for genetic medicines take shape. #timetraveltoseethefuture
Auchincloss said a focus needs to be maintaining the US as a hub for discovery and basic research that leads to new drug targets. endpoints.news/in-washingto...
In Washington, biotech's China hawks are winning the conversation
PhRMA and BIO mobilize against a wave of anti-China biotech bills in Congress as lawmakers move to curb US dealmaking with China.
endpoints.news
