A big thanks to Alissa @thetransmitter.bsky.social for highlighting our CA3 preprint!! Another interesting piece in the ‘cell diversity defining circuits’ puzzle! 🧩

The Transmitter @thetransmitter.bsky.social · yesterday

The hippocampal CA3 region may not be one uniform network after all. A new preprint identifies two distinct populations of pyramidal neurons, offering a new framework for understanding how memory circuits are organized. #neuroskyence By Alissa de Chassey www.thetransmitter.org/memory/textb...

We have a new preprint! By studying neuronal heterogeneity in CA3, we found a weird but powerful new feature in the hippocampal circuitry! 🧠 #neuroskyence 🧵.. Morse-Mora et al. | Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans doi.org/10.64898/202...

And it's a nice time to mention: from September, I'll be setting up human circuit research with Hospital del Mar in Barcelona. We want to use the amazing opportunity of surgical samples to explore how our own brain works. If you want to discuss ideas/collaborations/anything, lets chat at #FENS2026!!

Jake Watson@jakefwatson.bsky.social · last mo.

If you are at #FENS2026, we have a symposium on human circuits - from single cells and synapses to intact circuit function! It's not easy to investigate how our own brain works, but we will present recent work showing that it is possible at many scales. Wednesday afternoon at 15:40 - Hall E.

If you are at #FENS2026, we have a symposium on human circuits - from single cells and synapses to intact circuit function! It's not easy to investigate how our own brain works, but we will present recent work showing that it is possible at many scales. Wednesday afternoon at 15:40 - Hall E.

Happy birthday to the greatest Ambassador for Nature that we have. 100 years of teaching us the best reason to protect the natural world - it is incredible and beautiful! www.theguardian.com/tv-and-radio...

‘A true pinch-me moment’: memories of David Attenborough as he turns 100

Stories of chance encounters at home and abroad and the influence of his programmes around the world

theguardian.com

New paper from the lab! "Plasticity and language in the anaesthetized human hippocampus" www.nature.com/articles/s41...

Plasticity and language in the anaesthetized human hippocampus - Nature

In the hippocampus, complex processing of sensory stimuli occurs even in the unconscious state.

nature.com

If you are interested in circuit development - Victor Vargas-Barroso‘s thorough work on CA3 is now online. He shows surprising synaptic properties and circuit arrangement in the early postnatal hippocampus! www.nature.com/articles/s41...

To reduce disease, we all need to make some urgent but simple changes to how we feed our garden birds. See our website for the latest guidance: brnw.ch/21x1t4w

If you are interested in systems neuroscience, learning about data analysis, or understanding how the conceptualization of analyses can influence results, join us for the Brainhack satellite event at #FENS2026! More info at: pre-fens-brainhack.github.io/brainhack2026/

"The results are astonishingly clear. On rewilded land, biodiversity surged across the board, with the number of bird species up 261%. The variety of bumblebee and butterfly species more than doubled, their abundance increased over 10x." The cure for nature loss exists. share.google/w30RUdw1902W...

Rewilding linked to dramatic increases in birds across Scotland

New research across Scotland's Northwoods Rewilding Network has revealed striking biodiversity gains on rewilded land, with bird diversity increasing by more than 260% and pollinating insects rising m...

share.google

🧠🪰 The adult Drosophila brain connectome now gives us a complete wiring diagram of ~140k neurons. But a wiring diagram alone isn’t understanding. How is this massive network organized? Our paper tackles that question by mapping community structure across the entire fly brain. 1/

Rick Betzel@richardfbetzel.bsky.social · 8mo ago

New lab paper - will say more about this in a little while

🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com 🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals. www.nature.com/articles/s41... Join us: penglab.de

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum

AMPA receptors (AMPARs) are multimodal transducers of glutamatergic signals throughout the brain. Their diversity is exemplified in the cerebellum; at afferent synapses, AMPARs mediate high-frequency ...

science.org

Our paper on 'mini analysis' is now published in @jphysiol.bsky.social If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..! Happy to discuss if you are interested physoc.onlinelibrary.wiley.com/doi/10.1113/...

‘Mini analysis’ misrepresents changes in synaptic properties due to incomplete event detection

Abstract figure legend Summary of the study where simulated recordings (left) were used to characterise the effect of incomplete detection on mini (mPSC) analysis. Recording noise levels (red) determ...

physoc.onlinelibrary.wiley.com

Extremely happy to share our lab’s first paper now published in @NatureSMB! We determined the cryo-EM structures of GluA4, both alone and in complex with TARP2, capturing the receptor in different functional states.

Nature Structural & Molecular Biology@natsmb.nature.com · 11mo ago

New online: GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins

Finding correlates of the same signal in different brain areas is not evidence against specialisation, it is evidence for interconnection. When I flush my toilet, the level in the tank and the flow rate in the supply pipe become perfectly correlated. Yet these toilet areas have distinct functions.

Ben Hayden@benhayden.bsky.social · 11mo ago

Sad day for peope who still believe brain areas are the primary organizational units of function in the brain. www.nature.com/articles/s41...

Are you passionate about advancing cutting-edge imaging technologies, and combine expansion microscopy with the power of AI@HHMI to unlock new biological discoveries? If you’re ready for a creative,and impactful journey, we’d love for you to apply! hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Research Specialist - Expansion Microscopy

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute’s Janelia Research Campus is a pio...

hhmi.wd1.myworkdayjobs.com

Our work looking into heterogeneous pyramidal neurons (PNs) in hippocampal CA3 is now online @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti... With a pile of multicellular recordings from mouse CA3, we characterised the recurrent network at the single cell level...

Cell-specific wiring routes information flow through hippocampal CA3

The hippocampus, critical for learning and memory, is dogmatically described as a trisynaptic circuit where dentate gyrus granule cells (GCs), CA3 pyr…

sciencedirect.com

If you are interested in a position working on the coolest new developments in connectomics - take a serious look at this. Incredible technology development opportunity, working with a super nice scientist! Check out the paper here if you haven’t seen it yet: www.nature.com/articles/s41...

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature

A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

nature.com

@mojtabart.bsky.social · last yr.

🧠 Excited by synapse-level brain mapping? Join us at a world-class institute to build molecular tools based on our new #LICONN work — and push the frontier of #MolecularConnectomics. Let’s decode the brain, one synapse at a time. hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Really beautiful hippocampal connectomics from @zhihaozheng.bsky.social et al. Such high quality data shows many interesting circuit wiring surprises - an incredible resource to digest! Great also to see the parallels with our physiology work on neuronal heterogeneity www.biorxiv.org/content/10.1...

Connectomic reconstruction from hippocampal CA3 reveals spatially graded mossy fiber inputs and selective feedforward inhibition to pyramidal cells

The mossy fiber (MF) connections to pyramidal cells in hippocampal CA3 are hypothesized to participate in pattern separation and memory encoding, yet no large–scale neuronal wiring diagram exists for ...

biorxiv.org

I'm pleased to share our new work, “Spatio-temporal organization of network activity patterns in the hippocampus”, out in @cp-cellreports.bsky.social ! With Demi Brizee & David Dupret, we track how oscillations and spiking behaviour map onto hippocampal layers using an LFP-based embedding. (1/13)

If you are using IVA Cloning for your plasmid work... there is a cool new tool to make primer design very easy: ivaprime.com The explanation paper is here: academic.oup.com/nar/advance-...

IVA Prime: automated primer design for in vivo assembly cloning

Abstract. Molecular cloning through in vivo assembly (IVA) is an efficient homology-based approach that can achieve complex cloning operations in a single

academic.oup.com

Incredibly impressive and powerful new method - connectomics with light microscopy! Congrats @mojtabart.bsky.social, Hans Danzl and team @istaresearch.bsky.social ! It works incredibly well - we will keep using this magic, and recommend you do too!

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature

A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

nature.com

Given all that is going on consider this quote from Bertram Russell's 1930 book The conquest of Happiness: “The man who can be interested in the structure of atoms or the way in which a beetle navigates, is likely to get a joy in life which no amount of success in the pursuit of power can give. ”

The Neural Mechanisms of Cognitive Function meeting in beautiful #Pipa has sadly come to an end, but this meeting has given me new faith that really fascinating and innovative science is fully compatible with a kind, considerate, and supportive atmosphere! #BeNiceAndEnjoyYourScience

Striking insights into the information content of hippocampal subpopulations! A really stunning example of how understanding discrete cell types brings coherence and clarity to complex neuronal activity. Congrats to all

Liset M. de la Prida@lmprida.bsky.social · last yr.

New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social

Beautiful and thorough dissection of neuronal heterogeneity! Individual cells matter.

mark cembrowski@markcembrowski.bsky.social · last yr.

delighted to share our work revealing a new type of excitatory hippocampal neuron we call the "ovoid cell", which has really exquisite properties relative to adjacent pyramidal cells! superb work of first-author @adriennekinman.bsky.social and many others in the lab www.nature.com/articles/s41...

The new issue is out!! 👉 cell.com/cell/current Featuring the engineering of source-sink relations to⁠ create climate-smart crops, how ongoing chromothripsis drives tumor evolution across sarcomas and carcinomas, and the intercellular propagation of pyroptosis! 📷: Jake Watson⁠

Possibly as exciting as the science - our view of.. ‘exploring brain function across species’ made the cover of Cell @cellpress.bsky.social Arranged with local ingredients while walking on Gimsøy, Norway! www.cell.com/cell/current (and paper below)

Jake Watson@jakefwatson.bsky.social · 2y ago

Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few

My new year's resolution was to work through the pile of almost-finished papers so... #PrePrintAlert #NeuroSkyence. This is an update to one we put out late 2021, which got delayed with Lilya (lead author) going on maternity leave (yay, lab baby! 🥰). A brief 🧵 1/ www.biorxiv.org/content/10.1...

Hippocampus does not appear to be a major target of thalamic nucleus reuniens

The prefrontal - hippocampal - entorhinal system is perhaps the most widely-studied circuit in cognitive and systems neuroscience, due to its role in supporting cognitive functions such as working mem...

biorxiv.org