Amar Sahay
@amarsahay.bsky.social
Professor @ MGH & Harvard Medical School. Hippocampus + Cognition. www.sahaylab.com Engineering strategies to restore, maintain and enhance cognition since 2011. (U)Marathoner. Shark diver. Husband. Dad of human and wirehaired doxies
Grateful for this land. Great Meadows, Concord MA. Long run in a big mileage week. Slow run, trail running shoes were great on 16 trail miles but no fun on the 5 road miles. Yet, when I looked around and up at this beautiful blue sky and sunshine, the “am I done?” was forgotten.
What a great choice. As a grad student, I remember reading this paper in Cell which featured a doberman asleep on the cover..
The New York Times@nytimes.com · 7d agoTwo scientists have identified a cause of the sleep disorder narcolepsy, which affects an estimated one in every 2,000 people in the U.S., after their research in animals laid the groundwork.
Enjoy the last weekend of summah. Not a Vogue reader, but couldnt resist including this issue in my long weekend reading list.
Onward Professor @travisgoode.bsky.social I have no doubt that you will be an awesome mentor, colleague and asset to your department and look forward to hearing about your lab’s discoveries!
Travis Goode@travisgoode.bsky.social · 2w ago🧪🧪🧪 (1/5) Beyond thrilled to announce that I’ll be starting my own lab as a Tenure-Track Assistant Professor at the University of Tennessee Health Science Center (@uthsc.bsky.social) in Jan 2027! #NewPI My lab will study the neurobiology of learning, memory, and motivation! 🧠🐭⚡️🔬
Wompatuck state park, Hingham, MA. Beautiful trails. MA has so much beautiful conservation land. Take care of the land for a good life! Thank you @ Mass DCR!
100% one of my all time favs: The starkness, stillness, and a dash of piercing loneliness…
Edward Hopper @edwardhopper.bsky.social · 8mo agoEdward Hopper knew that people could be lonely despite being together. He showed how modern America turned shared spaces into isolated cells. But he also knew how deep human bonds could go when the world is seen through shared eyes. 🧵👇 #artbots #hopper
@amarsahay.bsky.social shares his lab’s discovery that many ultra-high confidence risk genes for autism, bipolar disorder, schizophrenia, and epilepsy may be regulators of experience-dependent plasticity of inhibitory neurons in the hippocampus of adult mice. brain.harvard.edu/hbi_news/a-s...
A Shared Mechanism for Cognitive Restoration and Seizure Suppression in Neurodevelopment Disorders
Amar Sahay shares his lab’s discovery that many ultra-high confidence risk genes for autism, bipolar disorder, schizophrenia, and epilepsy may be regulators of experience-dependent plasticity of inhib...
brain.harvard.edu
Many miles morning run to round off a big mileage week after a supination sprain. So much of training is adapting and evolving, learning when and how to return to the training plan. And when you do the joy is infinite.. Plan the runs. Run the plan.
Excited to share our discovery of a convergent mechanism for cognitive restoration and seizure suppression in neurodevelopment disorders in Nature (Open Access www.nature.com/articles/s41...). Led by two amazing neuroscientists, @yutzushih.bsky.social and @jasonalipio.bsky.social + a great team 1/2
Experience-dependent interneuron plasticity may represent a convergent circuit mechanism for these neurodevelopmental risk genes that reflects a shared genetic architecture, a new study suggests. By @claudia-lopez.bsky.social www.thetransmitter.org/spectrum/los...
Neurodevelopmental conditions may share faulty plasticity
Restoring expression of an experience-dependent interneuron plasticity gene aids memory and cuts seizures in CNTNAP2 knockout mice, a new study shows.
thetransmitter.org
Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...
Amazing! Allelle-specific ASO-dependent disease modifying effects in 9 and 14 year old Ms carrying causal SCN2A (GOF and LOF/mixed variants): Ameliorative effects seen on seizures, cognitive impairments, autistic behaviors, + autonomic (GI) dysfunction! www.nature.com/articles/s41...
Individualized antisense oligonucleotides for SCN2A-related developmental epileptic encephalopathy - Nature Medicine
In two patients with SCN2A epileptic encephalopathy, treatment with personalized allele-selective antisense oligonucleotides led to a decrease in seizure frequency with a positive safety profile.
nature.com
Anyway you cut it, the match of the last five decades! Inglaterra y Argentina: Avenging the hand of God. Period. Karma! Boom!
We have a new preprint! By studying neuronal heterogeneity in CA3, we found a weird but powerful new feature in the hippocampal circuitry! 🧠 #neuroskyence 🧵.. Morse-Mora et al. | Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans doi.org/10.64898/202...
Shark week coming up: Wait for your moment of Zen. Location: Off NC coast, sunken U352 is a feeding station / haven for these beautiful sand tigers. Water temps: 75-80F, Depth 80-120 feet. Nitrox.
The choice to VAR Is what makes it subPAR Many a goal is denied And ruling decried. Even Ogden Nash Wouldnt bet Cash On a VAR bet Without Regret.
Var Vargr: Blue Flame Skull
ALT: Var Vargr: Blue Flame Skull
static.klipy.com
Sad and painful to see the cost of assault on graduate programs in Biomedical Research across our nation. We MUST regain our trajectory before it is too late. #sciencematters Research Universities Are Admitting Fewer Ph.D.s, a Bad Sign for Science www.nytimes.com/2026/07/06/u...
Research Universities Are Admitting Fewer Ph.D.s, a Bad Sign for Science
nytimes.com
